• 3718 Citations
  • 35 h-Index
1993 …2020

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2020

Intracellular Growth and Cell Cycle Progression are Dependent on (p)ppGpp Synthetase/Hydrolase in Brucella abortus

Van der Henst, M., Carlier, E. & De Bolle, X., 14 Jul 2020, In : Pathogens. 9, 7, p. 1-13 13 p., 571.

Research output: Contribution to journalArticle

Open Access
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Shedding of Brucella melitensis happens through milk macrophages in the murine model of infection

Jansen, W., Demars, A., Nicaise, C., Godfroid, J., De Bolle, X., Reboul, A. & Al Dahouk, S., 1 Dec 2020, In : Scientific Reports. 10, 1, 9421.

Research output: Contribution to journalArticle

Open Access
2019

Localized incorporation of outer membrane components in the pathogen Brucella abortus

Vassen, V., Valotteau, C., Feuillie, C., Formosa-Dague, C., Dufrêne, Y. F. & De Bolle, X., 1 Mar 2019, In : The EMBO journal. 38, 5, e100323.

Research output: Contribution to journalArticle

Occurrence and repair of alkylating stress in the intracellular pathogen Brucella abortus

Poncin, K., Roba, A., Jimmidi, R., Potemberg, G., Fioravanti, A., Francis, N., Willemart, K., Zeippen, N., Machelart, A., Biondi, E. G., Muraille, E., Vincent, S. P. & De Bolle, X., 24 Oct 2019, In : Nature Communications. 10, 1, p. 4847 4847.

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Route of Infection Strongly Impacts the Host-Pathogen Relationship

Demars, A., Lison, A., Machelart, A., Van Vyve, M., Potemberg, G., Vanderwinden, J-M., De Bolle, X., Letesson, J-J. & Muraille, E., 1 Jan 2019, In : Frontiers in Immunology. 10, JULY, p. 1589 23 p., 1589.

Research output: Contribution to journalArticle

Open Access
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2018
Open Access
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PBP2b plays a key role in both peripheral growth and septum positioning in Lactococcus lactis

David, B., Duchêne, M-C., Haustenne, G. L., Pérez-Núñez, D., Chapot-Chartier, M-P., De Bolle, X., Guédon, E., Hols, P. & Hallet, B., 1 May 2018, In : PLoS ONE. 13, 5, p. e0198014 e0198014.

Research output: Contribution to journalArticle

Transposon sequencing of Brucella abortus uncovers essential genes for growth in vitro and inside macrophages

Sternon, J-F., Godessart, P., Gonçalves de Freitas, R., Van der Henst, M., Poncin, K., Francis, N., Willemart, K., Christen, M., Christen, B., Letesson, J-J. & De Bolle, X., 1 Aug 2018, In : Infection and Immunity. 86, 8, e00312-18.

Research output: Contribution to journalArticle

2017

CtrA Controls Cell Division and Outer Membrane Composition of the Pathogen Brucella abortus

Francis, N., Poncin, K., Fioravanti, A., Vassen, V., Willemart, K., Ong, T. A. P., Rappez, L., Letesson, J-J., Biondi, E. G. & De Bolle, X., Mar 2017, In : Molecular Microbiology. 103, 5, p. 780-797 18 p.

Research output: Contribution to journalArticle

Erythritol availability in bovine, murine and human models highlights a potential role for the host aldose reductase during Brucella infection

Barbier, T., Machelart, A., Zúñiga-Ripa, A., Plovier, H., Hougardy, C., Lobet, E., Willemart, K., Muraille, E., De Bolle, X., Van Schaftingen, E., Moriyón, I. & Letesson, J. J., 13 Jun 2017, In : Frontiers in Microbiology. 8, JUN, 1088.

Research output: Contribution to journalArticle

Open Access
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OXA-427, a new plasmid-borne carbapenem-hydrolysing class D β-lactamase in Enterobacteriaceae

Bogaerts, P., Naas, T., Saegeman, V., Bonnin, R. A., Schuermans, A., Evrard, S., Bouchahrouf, W., Jove, T., Tande, D., de Bolle, X., Huang, T. D., Dortet, L. & Glupczynski, Y., 1 Sep 2017, In : The Journal of antimicrobial chemotherapy. 72, 9, p. 2469-2477 9 p.

Research output: Contribution to journalArticle

2016

Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains

Suárez-Esquivel, M., Ruiz-Villalobos, N., Castillo-Zeledón, A., Jiménez-Rojas, C., Roop, R. M., Comerci, D. J., Barquero-Calvo, E., Chacón-Díaz, C., Caswell, C. C., Baker, K. S., Chaves-Olarte, E., Thomson, N. R., Moreno, E., Letesson, J. J., De Bolle, X. & Guzmán-Verri, C., 2016, In : Frontiers in Microbiology. 7, SEP

Research output: Contribution to journalArticle

Open Access
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36 Downloads (Pure)
Open Access

Phosphotransferase-dependent accumulation of (p)ppGpp in response to glutamine deprivation in Caulobacter crescentus

Ronneau, S., Petit, K., De Bolle, X. & Hallez, R., 25 Apr 2016, In : Nature Communications. 7, 11423.

Research output: Contribution to journalArticle

Open Access
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33 Downloads (Pure)
2015

A NAD-dependent glutamate dehydrogenase coordinates metabolism with cell division in Caulobacter crescentus

Beaufay, F., Coppine, J., Mayard, A., Laloux, G., De Bolle, X. & Hallez, R., 2 Jul 2015, In : The EMBO journal. 34, 13, p. 1786-1800 15 p.

Research output: Contribution to journalArticle

Open Access
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Brucella abortus Cell Cycle and Infection Are Coordinated

De Bolle, X., Crosson, S., Matroule, J-Y. & Letesson, J-J., 2015, In : Trends in Microbiology.

Research output: Contribution to journalArticle

2014

G1-arrested newborn cells are the predominant infectious form of the pathogen Brucella abortus

Deghelt, M., Mullier, C., Sternon, J-F., Francis, N., Laloux, G., Dotreppe, D., Van der Henst, C., Jacobs-Wagner, C., Letesson, J-J. & De Bolle, X., 2014, In : Nature Communications. 5, p. 4366 11 p.

Research output: Contribution to journalArticle

Open Access
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Insights into the function of YciM, a heat shock membrane protein required to maintain envelope integrity in escherichia coli

Nicolaes, V., Hajjaji, H. E., Davis, R. M., Van der Henst, C., Depuydt, M., Leverrier, P., Aertsen, A., Haufroid, V., de Choudens, S. O., De Bolle, X., Ruiz, N. & Collet, J. F., 1 Jan 2014, In : Journal of Bacteriology. 196, 2, p. 300-309 10 p.

Research output: Contribution to journalArticle

4 Downloads (Pure)

On the link between cell cycle and infection of the Alphaproteobacterium Brucella abortus

Letesson, J-J., De Bolle, X. & Deghelt, M., 2014, In : microbial cell. 1, 10, p. 346-348

Research output: Contribution to journalArticle

Open Access
Open Access
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The quest for a true One Health perspective of brucellosis

Godfroid, J., De bolle, X., Roop, R. M., O'Callaghan, D., Tsolis, R. M., Baldwin, C., Santos, R. L., McGiven, J., Olsen, S., Nymo, I. H., Larsen, A., Al Dahouk, S. & Letesson, J. J., Aug 2014, In : OIE Revue Scientifique et Technique. 33, 2, p. 521-538 18 p.

Research output: Contribution to journalArticle

2013
Open Access
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BtaE, an adhesin that belongs to the trimeric autotransporter family, is required for full virulence and defines a specific adhesive pole of Brucella suis

Ruiz-Ranwez, V., Posadas, D. M., Van der Henst, C., Estein, S. M., Arocena, G. M., Abdian, P. L., Martín, F. A., Sieira, R., De Bolle, X. & Zorreguieta, A., 1 Mar 2013, In : Infection and Immunity. 81, 3, p. 996-1007 12 p.

Research output: Contribution to journalArticle

Open Access
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27 Downloads (Pure)

Innate immune recognition of flagellin limits systemic persistence of Brucella

Terwagne, M., Ferooz, J., Rolán, H. G., Sun, Y. H., Atluri, V., Xavier, M. N., Franchi, L., Núñez, G., Legrand, T., Flavell, R. A., De Bolle, X., Letesson, J-J. & Tsolis, R. M., 1 Jun 2013, In : Cellular microbiology. 15, 6, p. 942-960 19 p.

Research output: Contribution to journalArticle

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Quorum sensing and self-quorum quenching in the intracellular pathogen Brucella melitensis

Terwagne, M., Mirabella, A., Lemaire, J., Deschamps, C., De Bolle, X. & Letesson, J-J., 11 Dec 2013, In : PLoS ONE. 8, 12, e82514.

Research output: Contribution to journalArticle

Open Access
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The Brucella pathogens are polarized bacteria

Van der Henst, C., de Barsy, M., Zorreguieta, A., Letesson, J-J. & De Bolle, X., 1 Dec 2013, In : Microbes and infection : a journal on infectious agents and host defenses. 15, 14-15, p. 998-1004 7 p.

Research output: Contribution to journalArticle

2012

A Brucella abortus cstA mutant is defective for association with endoplasmic reticulum exit sites and displays altered trafficking in HeLa cells

de Barsy, M., Mirabella, A., Letesson, J-J. & De Bolle, X., 2012, In : Microbiology. 158, Pt 10, p. 2610-8 9 p.

Research output: Contribution to journalArticle

Polar growth in the Alphaproteobacterial order Rhizobiales

Brown, P. J. B., de Pedro, M. A., Kysela, D. T., Van der Henst, C., Kim, J., De Bolle, X., Fuqua, C. & Brun, Y. V., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 5, p. 1697-701 5 p.

Research output: Contribution to journalArticle

7 Downloads (Pure)
6 Downloads (Pure)

Small GTPases and Brucella entry into the endoplasmic reticulum

de Bolle, X., Letesson, J-J. & Gorvel, J-P., 2012, In : Biochemical Society transactions. 40, 6, p. 1348-52 5 p.

Research output: Contribution to journalArticle

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The histidine kinase PdhS controls cell cycle progression of the pathogenic alphaproteobacterium Brucella abortus

Van der Henst, C., Beaufay, F., Mignolet, J., Didembourg, C., Colinet, J., Hallet, B., Letesson, J-J. & De Bolle, X., 2012, In : Journal of Bacteriology. 194, 19, p. 5305-14 10 p.

Research output: Contribution to journalArticle

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The two-component system PrlS/PrlR of Brucella melitensis is required for persistence in mice and appears to respond to ionic strength

Mirabella, A., Yañez Villanueva, R-M., Delrue, R-M., Uzureau, S., Zygmunt, M. S., Cloeckaert, A., De Bolle, X. & Letesson, J-J., 2012, In : Microbiology. 158, Pt 10, p. 2642-51 10 p.

Research output: Contribution to journalArticle

2011

Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2

de Barsy, M., Jamet, A., Filopon, D., Nicolas, C., Laloux, G., Rual, J-F., Muller, A., Twizere, J-C., Nkengfac, B., Vandenhaute, J., Hill, D. E., Salcedo, S. P., Gorvel, J-P., Letesson, J-J. & De Bolle, X., 1 Jul 2011, In : Cellular microbiology. 13, 7, p. 1044-58 15 p.

Research output: Contribution to journalArticle

RpoE1, an extracytoplasmic function sigma factor, is a repressor of the flagellar system in Brucella melitensis

Ferooz, J., Lemaire, J., Delory, M., De Bolle, X. & Letesson, J-J., 1 May 2011, In : Microbiology. 157, 5, p. 1263-8 6 p.

Research output: Contribution to journalArticle

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2010

Brucella melitensis 16M produces a mannan and other extracellular matrix components typical of a biofilm

Godefroid, M., Uzureau, S., Mirabella, A., De Bolle, X., Letesson, J-J., Svensson, M. V., Widmalm, G., Cambier, P. & Van Cutsem, P., 1 Aug 2010, In : FEMS Immunology and Medical Microbiology. 59, 3, p. 364-377 14 p.

Research output: Contribution to journalArticle

Functional characterization of the incomplete phosphotransferase system (PTS) of the intracellular pathogen brucella melitensis

Dozot, M., Nicolas, C., Copin, R., de Bolle, X., Letesson, J-J., Poncet, S., Bouraoui, H., Mazé, A. & Deutscher, J., 1 Jan 2010, In : PLoS ONE. 5, 9, p. 1-16 16 p.

Research output: Contribution to journalArticle

Open Access
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Global analysis of quorum sensing targets in the intracellular pathogen brucella melitensis 16 M

Uzureau, S., Lemaire, J., Delaive, E., Dieu, M., Gaigneaux, A., Raes, M., De Bolle, X. & Letesson, J-J., 4 Jun 2010, In : Journal of Proteome Research. 9, 6, p. 3200-3217 18 p.

Research output: Contribution to journalArticle

Open Access
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78 Downloads (Pure)
Open Access
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33 Downloads (Pure)

PdhS, an old-pole-localized histidine kinase, recruits the fumarase FumC in Brucella abortus

Mignolet, J., Van der Henst, C., Nicolas, C., Deghelt, M., Dotreppe, D., Letesson, J-J. & De Bolle, X., 2010, In : J Bacteriol. 192, 12, p. 3235-9 5 p.

Research output: Contribution to journalArticle

Open Access
1 Downloads (Pure)
2008

Intracellular rescuing of a B. melitensis 16M virB mutant by co-infection with a wild type strain

Nijskens, C., Copin, R., De Bolle, X. & Letesson, J-J., 2008, In : Microbial pathogenesis. 45, p. 134-141 8 p.

Research output: Contribution to journalArticle

2007

FtcR is a new master regulator of the flagellar system of Brucella melitensis 16M with homologs in Rhizobiaceae

Léonard, S., Ferooz, J., Haine, V., Danese, I., Fretin, D., Tibor, A., De Walque, S., De Bolle, X. & Letesson, J. J., 1 Jan 2007, In : J. Bacteriol. 189, 1, p. 131-141 11 p.

Research output: Contribution to journalArticle

Mutations of the Quorum sensing-dependent regulator VjbR lead to drastic surface modifications in Brucella melitensis

Bonnot, S., Godefroid, M., Deschamps, C., Lemaire, J., De Bolle, X. & Letesson, J-J. (ed.), 2007, In : J. Bacteriol. 189, p. 6035-6047 13 p.

Research output: Contribution to journalArticle

The asymmetric distribution of the essential histidine kinase PdhS indicates a differentiation event in Brucella abortus

Hallez, R., Mignolet, J., Van Mullem, V., Wery, M., Vandenhaute, J., Letesson, J-J., Jacobs-Wagner, C. & De Bolle, X., 2007, In : The EMBO journal. 26, p. 1444-55 12 p.

Research output: Contribution to journalArticle

2006

NnrA is required for full virulence and regulates several Brucella melitensis denitrification genes

Haine, V., Dozot, M., Dornand, J., Letesson, J-J. & De Bolle, X., 2006, In : J Bacteriol. 188, 4, p. 1615-1619 5 p.

Research output: Contribution to journalArticle