Metabolic control of cell division in α-proteobacteria by a NAD-dependent glutamate dehydrogenase

François Beaufay, Xavier De Bolle, Régis Hallez

Research output: Contribution to journalArticle


Prior to initiate energy-consuming processes, such as DNA replication or cell division, cells need to evaluate their metabolic status. We have recently identified and characterized a new connection between metabolism and cell division in the a-proteobacterium Caulobacter crescentus. We showed that an NAD-dependent glutamate dehydrogenase (GdhZ) coordinates growth with cell division according to its enzymatic activity. Here we report the conserved role of GdhZ in controlling cell division in another α-proteobacterium, the facultative intracellular pathogen Brucella abortus. We also discuss the importance of amino acids as a main carbon source for α-proteobacteria.

Original languageEnglish
JournalCommunicative and Integrative Biology
Issue number1
Publication statusPublished - 2016



  • A-proteobacteria
  • Brucella
  • Caulobacter
  • Cell division
  • Cytokinesis
  • FstZ
  • GdhZ
  • Glutamate dehydrogenase

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