Brucella abortus Cell Cycle and Infection Are Coordinated

Research output: Contribution to journalArticle


Brucellae are facultative intracellular pathogens. The recent development of methods and genetically engineered strains allowed the description of cell-cycle progression of. Brucella abortus, including unipolar growth and the ordered initiation of chromosomal replication. B. abortus cell-cycle progression is coordinated with intracellular trafficking in the endosomal compartments. Bacteria are first blocked at the G1 stage, growth and chromosome replication being resumed shortly before reaching the intracellular proliferation compartment. The control mechanisms of cell cycle are similar to those reported for the bacterium. Caulobacter crescentus, and they are crucial for survival in the host cell. The development of single-cell analyses could also be applied to other bacterial pathogens to investigate their cell-cycle progression during infection. Brucella abortus is a facultative intracellular pathogen that grows unipolarly and initiates the replication of its two chromosomes in a specific order.Bacteria at the G1 stage of the cell cycle, that is, before the initiation of their chromosomal replication, are preferentially internalized in host cells.Cell-cycle progression is coordinated with trafficking in the host cell, the endosomal stage being divided into two parts: a first, long, nongrowing part, and a second part in which growth and chromosomal replication are resumed.A cell-cycle control network, conserved with the model bacterium. Caulobacter crescentus, is essential for. B. abortus virulence.

Original languageEnglish
JournalTrends in Microbiology
Publication statusPublished - 2015


  • Brucella
  • Cell cycle
  • Growth
  • Intracellular infection
  • Replication

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    Connecting the cell cycle and the pathogenicity of Brucella abortus. When a specific bacterial cell cycle arrest in G1 phase takes part in the colonization of mammalian cells

    Author: Deghelt, M., 16 Dec 2013

    Supervisor: De Bolle, X. (Supervisor), Letesson, J. (Supervisor), Muylkens, B. (Jury), Van Doninck, K. (President), THANBICHLER, M. (External person) (Jury) & ROOP II, R. M. (External person) (Jury)

    Student thesis: Doc typesDoctor of Sciences

    CtrA-dependant cell cycle regulation of Brucella abortus in culture and during infection

    Author: Francis, N., 1 Dec 2015

    Supervisor: De Bolle, X. (Supervisor), Renard, P. (President), Crosson, S. (External person) (Jury), Biondi, E. (External person) (Jury) & Collet, J. (External person) (Jury)

    Student thesis: Doc typesDoctor of Sciences


    On the link between Brucella abortus cell cycle and adaptation to its intracellular lifestyle

    Author: Mullier, C., 24 Jan 2014

    Supervisor: De Bolle, X. (Supervisor), Renard, P. (President), Jadot, M. (Jury), Matroule, J. (Jury), Salcedo, S. P. (External person) (Jury) & Collet, J. (External person) (Jury)

    Student thesis: Doc typesDoctor of Sciences

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