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Research Output

Crystal structure of a cold-adapted class C β-lactamase

Michaux, C., Massant, J., Kerff, F., Frère, J. M., Docquier, J. D., Vandenberghe, I., Samyn, B., Pierrard, A., Feller, G., Charlier, P., Van Beeumen, J. & Wouters, J., 1 Apr 2008, In : FEBS Journal. 275, 8, p. 1687-1697 11 p.

Research output: Contribution to journalArticle

Crystal structure of Enterobacter cloacae 908R class C β-lactamase bound to iodo-acetamido-phenyl boronic acid, a transition-state analogue

Wouters, J., Fonzé, E., Vermeire, M., Frère, J. M. & Charlier, P., 1 Aug 2003, In : Cellular and Molecular Life Sciences. 60, 8, p. 1764-1773 10 p.

Research output: Contribution to journalArticle

Crystal Structure of the C67A Mutant of Isopentenyl Diphosphate Isomerase Complexed with a Mechanism-Based Irreversible Inhibitor

Wouters, J., Oudjama, Y., Stalon, V., Droogmans, L. & Poulter, C. D., 1 Feb 2004, In : Proteins: Structure, Function and Genetics. 54, 2, p. 216-221 6 p.

Research output: Contribution to journalArticle

Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling

Labar, G., Bauvois, C., Borel, F., Ferrer, J. L., Wouters, J. & Lambert, D. M., 25 Jan 2010, In : ChemBioChem. 11, 2, p. 218-227 10 p.

Research output: Contribution to journalArticle

Crystal structure of type 2 isopentenyl diphosphate isomerase from Thermus thermophilus in complex with inorganic pyrophosphate

De Ruyck, J., Pouyez, J., Rothman, S. C., Poulter, D. & Wouters, J., 2 Sep 2008, In : Biochemistry. 47, 35, p. 9051-9053 3 p.

Research output: Contribution to journalArticle

Crystal structures of class C β-lactamases: mechanistic implications and perspectives in drug design

Bauvois, C. & Wouters, J., 2007, Enzyme-mediated resistance to antibiotics : mechanisms, dissemination, and prospects for inhibition. Robert, E., Bonomo, A. & Tolmasky, M. (eds.). Washington: ASM Press, p. 145-161 17 p.

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter

Crystal structures of low-melting ionic transition-metal complexes with N-alkylimidazole ligands

Vander Hoogerstraete, T., Brooks, N. R., Norberg, B., Wouters, J., Van Hecke, K., Van Meervelt, L. & Binnemans, K., 7 Aug 2012, In : CrystEngComm. 14, 15, p. 4902-4911 10 p.

Research output: Contribution to journalArticle

Cyproterone and a comparison with its acetate ester

De Ruyck, J., De Hassonville, S. H., Liégeois, J. F. & Wouters, J., 1 Nov 2005, In : Acta Crystallographica Section E. 61, 11

Research output: Contribution to journalArticle

Data in support of a harmine-derived beta-carboline in vitro effects in cancer cells through protein synthesis

Carvalho, A., Chu, J., Meinguet, C., Kiss, R., Vandenbussche, G., Masereel, B., Wouters, J., Kornienko, A., Pelletier, J. & Mathieu, V., 1 Jun 2017, In : Data in Brief. 12, p. 546-551 6 p.

Research output: Contribution to journalArticle

Design, synthesis, and anticonvulsant activity of 1-(pyrid-3- ylsulfonamido)-2-nitroethylenes

Masereel, B., Wouters, J., Pochet, L. & Lambert, D., 13 Aug 1998, In : Journal of Medicinal Chemistry. 41, 17, p. 3239-3244 6 p.

Research output: Contribution to journalArticle

Design, synthesis and biological evaluation of indanesulfonamides as carbonic anhydrase IX inhibitors

Thiry, A., Ledecq, M., Cecchi, A., Dogné, J-M., Wouters, J., Supuran, C. T. & Masereel, B., 2006, In : Fundamental and Clinical Pharmacology. 20

Research output: Contribution to journalLiterature review

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Design, synthesis and evaluation of graftable thrombin inhibitors for the preparation of blood-compatible polymer materials

Salvagnini, C., Michaux, C., Remiche, J., Wouters, J., Charlier, P. & Marchand-Brynaert, J., 7 Dec 2005, In : Organic and Biomolecular Chemistry. 3, 23, p. 4209-4220 12 p.

Research output: Contribution to journalArticle

Design, synthesis and study of inhibitors of tryptophan 2,3-dioxygenase (TDO), a promising target for cancer therapy

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2010, p. Abstracts, école doctorale SFMBBM, Liège, Belgium, 10 December 2010. 1 p.

Research output: Contribution to conferencePoster

Open Access

Determination of kinetics and the crystal structure of a novel type 2 isopentenyl diphosphate: Dimethylallyl diphosphate isomerase from streptococcus pneumoniae

De Ruyck, J., Janczak, M. W., Neti, S. S., Rothman, S. C., Schubert, H. L., Cornish, R. M., Matagne, A., Wouters, J. & Poulter, C. D., 7 Jul 2014, In : ChemBioChem. 15, 10, p. 1452-8 7 p.

Research output: Contribution to journalArticle

Determination of physical changes of inulin related to sorption isotherms: An X-ray diffraction, modulated differential scanning calorimetry and environmental scanning electron microscopy study

Ronkart, S., Blecker, C., Fougnies, C., Van Herck, J. C., Wouters, J. & Paquot, M., 3 Feb 2006, In : Carbohydrate Polymers. 63, 2, p. 210-217 8 p.

Research output: Contribution to journalArticle

Determination of the Absolute Configuration of Aegelinol by Crystallization of Its Inclusion Complex with β-Cyclodextrin

Elasaad, K., Alkhatib, R., Hennebelle, T., Norberg, B. & Wouters, J., 26 Oct 2012, In : Crystals. 2, 4, p. 1441-1454 14 p.

Research output: Contribution to journalArticle

Open Access
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Developpement d'indanesulfonamides inhibiteurs de l'anhydrase carbonique IX

Thiry, A., Ledecq, M., Chazalette, C., Wouters, J., SUPURAN, C. T. & Masereel, B., 2005, Abstract Book-19èmes Journées Franco-Belge de pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Direct Access by Mechanochemistry or Sonochemistry to Protonated Merocyanines: Components of a Four‐State Molecular Switch

Colaço, M., Carletta, A., Van Gysel, M., Robeyns, K., Tumanov, N. & Wouters, J., 2 Jul 2018, In : ChemistryOPEN. 7, 7, p. 520-526 7 p.

Research output: Contribution to journalArticle

Open Access
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Direct access to 1-aryl-5-amino-1,2,4-triazoles and [1,2,4]triazolo[1,5-a] pyridines by two new single-step reactions from 1,3,4-thiadiazol-2-amines

Mammoliti, O., Quinton, E. M., Loones, K. T. J., Nguyen, A. T., Wouters, J. & Van Lommen, G., 4 Feb 2013, In : Tetrahedron. 69, 5, p. 1669-1680 12 p.

Research output: Contribution to journalArticle

Direct Orange 34 dye fixation by modified kaolin

Chargui, H., Hajjaji, W., Wouters, J., Yans, J. & Jamoussi, F., 1 Jan 2018, In : Clay Minerals. 53, 2, p. 271-287 17 p.

Research output: Contribution to journalArticle

Open Access

Discovery and Optimization Of Indole-pyridinyl-ethanones as Novel Inhibitors of Indoleamine-2,3-Dioxygenase (IDO), a Promising Target for Anti-Cancer Immunotherapy

Frédérick, R., Blanc, S., Larrieu, P., Moineaux, L., Colette, D., Fraser, G., Stroobant, V., Pilotte, L., Colau, D., Wouters, J., Masereel, B., Van den Eynde, B. & Dolusic, E., 2010, p. PC.281, 21st ISMC, Brussels, Belgium, September 5-9, 2010, Drugs of the Future, volume 35, issue suppl. A, pp. 181-182. 2 p.

Research output: Contribution to conferencePoster

Discovery and optimization of indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2-3 dioxygenase (IDO), a promising target for anti-cancer immunotherapy.

Frédérick, R., Blanc, S., Larrieu, P., Moineaux, L., Colette, D., Fraser, G., Stroobant, V., Pilotte, L., Colaux, D., Wouters, J., Masereel, B., Van den Eynde, B. & Dolušić, E., 2010, In : Drugs of the future. 35, suppl A, p. 181-182

Research output: Contribution to journalLiterature review

Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

Dolušić, E., Larrieu, P., Blanc, S., Sapunaric, F., Pouyez, J., Moineaux, L., Colette, D., Stroobant, V., Pilotte, L., Colau, D., Ferain, T., Fraser, G., Galleni, M., Frère, J-M., Masereel, B., Van Den Eynde, B., Wouters, J. & Frédérick, R., 2011, In : European Journal of Medicinal Chemistry. 46, 7, p. 3058-3065 8 p.

Research output: Contribution to journalArticle

Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling

Labar, G., Bauvois, C., Muccioli, G. G., Wouters, J. & Lambert, D. M., 23 Jul 2007, In : ChemBioChem. 8, 11, p. 1293-1297 5 p.

Research output: Contribution to journalArticle

Does chirality influence the tendency toward cocrystal formation?

George, F., Tumanov, N., Norberg, B., Robeyns, K., Filinchuk, Y., Wouters, J. & Leyssens, T., 4 Jun 2014, In : Crystal Growth and Design. 14, 6, p. 2880-2892 13 p.

Research output: Contribution to journalArticle

Effect of TAG composition on the crystallization behaviour of model fat blends with the same saturated fat content

Vereecken, J., De Graef, V., Smith, K. W., Wouters, J. & Dewettinck, K., 1 Oct 2010, In : Food research international. 43, 8, p. 2057-2067 11 p.

Research output: Contribution to journalArticle

Open Access
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Electronic transitions of neutral and anionic quinolinone HIV-1 integrase inhibitor: Joint theory/experiment investigation

Vandurm, P., Cauvin, C., Wouters, J., Perpète, E. A. & Jacquemin, D., 27 Aug 2009, In : Chemical Physics Letters. 478, 4-6, p. 243-248 6 p.

Research output: Contribution to journalArticle

Electrostatically-driven assembly of MWCNTs with a europium complex

Maggini, L., Traboulsi, H., Yoosaf, K., Mohanraj, J., Wouters, J., Pietraszkiewicz, O., Pietraszkiewicz, M., Armaroli, N. & Bonifazi, D., 7 Feb 2011, In : Chemical Communications. 47, 5, p. 1625-1627 3 p.

Research output: Contribution to journalArticle

Empirical and molecular modeling study of the pyridinium species RHPP+, an abundant and potentially neurotoxic metabolite of haloperidol

Ooms, F., Delvosal, S., Wouters, J., Durant, F., Dockendolf, G., Van't Land, C., Glass, T., Castagnoli, N. & Van Der Schyf, C. J., 1 Sep 2000, In : Journal of the Chemical Society. Perkin Transactions 2. 9, p. 1781-1787 7 p.

Research output: Contribution to journalArticle

Encapsulation and solid state sequestration of gases by calix[6]arene-based molecular containers

Lavendomme, R., Ajami, D., Moerkerke, S., Wouters, J., Rissanen, K., Luhmer, M. & Jabin, I., 2017, In : Chemical Communications. 53, 48, p. 6468-6471 4 p.

Research output: Contribution to journalArticle

Engineering solid-state molecular switches: N-salicylidene N-heterocycle derivatives

Robert, F., Naik, A. D., Hidara, F., Tinant, B., Robiette, R., Wouters, J. & Garcia, Y., 29 Jan 2010, In : European Journal of Organic Chemistry. 4, p. 621-637 17 p.

Research output: Contribution to journalArticle

Estimation of sucrose crystallization kinetics from batch crystallizer data

Ouiazzane, S., Messnaoui, B., Abderafi, S., Wouters, J. & Bounahmidi, T., 15 Feb 2008, In : Journal of Crystal Growth. 310, 4, p. 798-803 6 p.

Research output: Contribution to journalArticle

Étude des propriétés stéréoélectroniques de composés triaziniques en vue d'établir une relation structure-lipophilie

Longfils, G., Wouters, J., Marlier, C., Goldstein, S., Neuwels, M., Vankeulen, J., Evrard, G. & Durant, F., 1 Dec 1998, In : Journal de Pharmacie de Belgique. 53, 2, 1 p.

Research output: Contribution to journalArticle

Expedient, direct synthesis of (L)Pt(0)(1,6-diene) complexes from H 2PtCl6

Berthon-Gelloz, G., Schumers, J. M., Lucaccioni, F., Tinant, B., Wouters, J. & Markó, I. E., 5 Nov 2007, In : Organometallics. 26, 23, p. 5731-5734 4 p.

Research output: Contribution to journalArticle

Experimental and theoretical study of reversible monoamine oxidase inhibitors: Structural approach of the active site of the enzyme

Wouters, J., Moureau, F., Vercauteren, D. P., Evrard, G., Durant, F., Koenig, J. J., Ducrey, F. & Jarreau, F. X., 1 Jan 1994, In : Journal of Neural Transmission, Supplement. 41, p. 313-319 7 p.

Research output: Contribution to journalArticle

Exploration of the binding mode of indanesulfonamides as selective inhibitors of human carbonic anhydrase type VII by targeting Lys91

Thiry, A., Masereel, B., Dogne, J-M., Supuran, C. T., Wouters, J. & Michaux, C., 10 Sep 2007, In : ChemMedChem. 2, 9, p. 1273-1280 8 p.

Research output: Contribution to journalArticle

Exploration of the pharmacophore of 3-alkyl-5-arylimidazolidinediones as new CB1 cannabinoid receptor ligands and potential antagonists: Synthesis, lipophilicity, affinity, and molecular modeling

Ooms, F., Wouters, J., Oscari, O., Happaerts, T., Bouchard, G., Carrupt, P. A., Testa, B. & Lambert, D. M., 25 Apr 2002, In : Journal of Medicinal Chemistry. 45, 9, p. 1748-1756 9 p.

Research output: Contribution to journalArticle

Exploring polymorphism and stoichiometric diversity in naproxen/proline cocrystals

Tumanova, N., Tumanov, N., Fischer, F., Morelle, F., Ban, V., Robeyns, K., Filinchuk, Y., Wouters, J., Emmerling, F. & Leyssens, T., 1 Jan 2018, In : CrystEngComm. 20, 45, p. 7308-7321 14 p.

Research output: Contribution to journalArticle

Open Access
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First partial three-dimensional model of human monoamine oxidase A

Wouters, J. & Baudoux, G., 1 Jul 1998, In : Proteins: Structure, Function and Genetics. 32, 1, p. 97-110 14 p.

Research output: Contribution to journalArticle