Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

E. Dolušić; P. Larrieu; S. Blanc; F. Sapunaric; J. Pouyez; L. Moineaux; D. Colette; V. Stroobant; L. Pilotte; D. Colau; Thierry Ferain; G. Fraser; M. Galleni; Jean-Marie Frère; B. Masereel; B. Van Den Eynde; J. Wouters; R. Frédérick

doi:10.1016/j.ejmech.2011.02.049

Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

E. Dolušić, P. Larrieu, S. Blanc, F. Sapunaric, J. Pouyez, L. Moineaux, D. Colette, V. Stroobant, L. Pilotte, D. Colau, Thierry Ferain, G. Fraser, M. Galleni, Jean-Marie Frère, B. Masereel, B. Van Den Eynde, J. Wouters, R. Frédérick

Research output: Contribution to journal › Article › peer-review

Abstract

Indoleamine 2,3-dioxygenase (IDO) is an important new therapeutic target for the treatment of cancer. With the aim of discovering novel IDO inhibitors, a virtual screen was undertaken and led to the discovery of the keto-indole derivative 1a endowed with an inhibitory potency in the micromolar range. Detailed kinetics were performed and revealed an uncompetitive inhibition profile. Preliminary SARs were drawn in this series and corroborated the putative binding orientation as suggested by docking. © 2011 Elsevier Masson SAS. All rights reserved.

Original language	English
Pages (from-to)	3058-3065
Number of pages	8
Journal	European Journal of Medicinal Chemistry
Volume	46
Issue number	7
DOIs	https://doi.org/10.1016/j.ejmech.2011.02.049
Publication status	Published - 2011

Keywords

enzyme inhibitors
keto-indoles
Structure-activity relationships
Structure-based drug discovery
IDO
Indoleamine 2 3-dioxygenase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejmech.2011.02.049

Cite this

Dolušić, E., Larrieu, P., Blanc, S., Sapunaric, F., Pouyez, J., Moineaux, L., Colette, D., Stroobant, V., Pilotte, L., Colau, D., Ferain, T., Fraser, G., Galleni, M., Frère, J-M., Masereel, B., Van Den Eynde, B., Wouters, J., & Frédérick, R. (2011). Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. European Journal of Medicinal Chemistry, 46(7), 3058-3065. https://doi.org/10.1016/j.ejmech.2011.02.049

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title = "Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors",

abstract = "Indoleamine 2,3-dioxygenase (IDO) is an important new therapeutic target for the treatment of cancer. With the aim of discovering novel IDO inhibitors, a virtual screen was undertaken and led to the discovery of the keto-indole derivative 1a endowed with an inhibitory potency in the micromolar range. Detailed kinetics were performed and revealed an uncompetitive inhibition profile. Preliminary SARs were drawn in this series and corroborated the putative binding orientation as suggested by docking. {\textcopyright} 2011 Elsevier Masson SAS. All rights reserved.",

keywords = " enzyme inhibitors, keto-indoles, Structure-activity relationships, Structure-based drug discovery, IDO, Indoleamine 2 3-dioxygenase",

author = "E. Dolu{\v s}i{\'c} and P. Larrieu and S. Blanc and F. Sapunaric and J. Pouyez and L. Moineaux and D. Colette and V. Stroobant and L. Pilotte and D. Colau and Thierry Ferain and G. Fraser and M. Galleni and Jean-Marie Fr{\`e}re and B. Masereel and {Van Den Eynde}, B. and J. Wouters and R. Fr{\'e}d{\'e}rick",

year = "2011",

doi = "10.1016/j.ejmech.2011.02.049",

language = "English",

volume = "46",

pages = "3058--3065",

journal = "European Journal of Medicinal Chemistry",

issn = "1768-3254",

publisher = "Elsevier",

number = "7",

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Dolušić, E, Larrieu, P, Blanc, S, Sapunaric, F, Pouyez, J , Moineaux, L, Colette, D, Stroobant, V, Pilotte, L, Colau, D, Ferain, T, Fraser, G, Galleni, M, Frère, J-M, Masereel, B, Van Den Eynde, B, Wouters, J & Frédérick, R 2011, 'Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors', European Journal of Medicinal Chemistry, vol. 46, no. 7, pp. 3058-3065. https://doi.org/10.1016/j.ejmech.2011.02.049

TY - JOUR

T1 - Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

AU - Dolušić, E.

AU - Larrieu, P.

AU - Blanc, S.

AU - Sapunaric, F.

AU - Pouyez, J.

AU - Moineaux, L.

AU - Colette, D.

AU - Stroobant, V.

AU - Pilotte, L.

AU - Colau, D.

AU - Ferain, Thierry

AU - Fraser, G.

AU - Galleni, M.

AU - Frère, Jean-Marie

AU - Masereel, B.

AU - Van Den Eynde, B.

AU - Wouters, J.

AU - Frédérick, R.

PY - 2011

Y1 - 2011

N2 - Indoleamine 2,3-dioxygenase (IDO) is an important new therapeutic target for the treatment of cancer. With the aim of discovering novel IDO inhibitors, a virtual screen was undertaken and led to the discovery of the keto-indole derivative 1a endowed with an inhibitory potency in the micromolar range. Detailed kinetics were performed and revealed an uncompetitive inhibition profile. Preliminary SARs were drawn in this series and corroborated the putative binding orientation as suggested by docking. © 2011 Elsevier Masson SAS. All rights reserved.

AB - Indoleamine 2,3-dioxygenase (IDO) is an important new therapeutic target for the treatment of cancer. With the aim of discovering novel IDO inhibitors, a virtual screen was undertaken and led to the discovery of the keto-indole derivative 1a endowed with an inhibitory potency in the micromolar range. Detailed kinetics were performed and revealed an uncompetitive inhibition profile. Preliminary SARs were drawn in this series and corroborated the putative binding orientation as suggested by docking. © 2011 Elsevier Masson SAS. All rights reserved.

KW - enzyme inhibitors

KW - keto-indoles

KW - Structure-activity relationships

KW - Structure-based drug discovery

KW - IDO

KW - Indoleamine 2 3-dioxygenase

UR - http://www.scopus.com/inward/record.url?scp=79957472526&partnerID=8YFLogxK

U2 - 10.1016/j.ejmech.2011.02.049

DO - 10.1016/j.ejmech.2011.02.049

M3 - Article

SN - 1768-3254

VL - 46

SP - 3058

EP - 3065

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 7

ER -

Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

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Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

Abstract

Keywords

UN SDGs

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