Indoleamine 2,3-Dioxygenase Inhibitory Activity of Derivatives of Marine Alkaloid Tsitsikammamine A

Eduard Dolusic, Pierre Larrieu, Céline Meinguet, Delphine Colette, Arnaud Rives, Sébastien Blanc, Thierry Ferain, Luc Pilotte, Vincent Stroobant, Johan Wouters, Benoît Van den Eynde, Bernard Masereel, Evelyne Delfourne, Raphaël Frédérick

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Abstract

Tsitsikammamines are marine alkaloids whose structure is based on the pyrroloiminoquinone scaffold. These and related compounds have attracted attention due to various interesting biological properties, including cytotoxicity, topoisomerase inhibition, antimicrobial, antifungal and antimalarial activity. Indoleamine 2,3-dioxygenase (IDO1) is a well-established therapeutic target as an important factor in the tumor immune evasion mechanism. In this preliminary communication, we report the inhibitory activity of tsitsikammamine derivatives against IDO1. Tsitsikammamine A analogue 11b displays submicromolar potency in an enzymatic assay. A number of derivatives are also active in a cellular assay while showing little or no activity towards tryptophan 2,3-dioxygenase (TDO), a functionally related enzyme. This IDO1 inhibitory activity is rationalized by molecular modeling studies. An interest is thus established in this class of compounds as a potential source of lead compounds for the development of new pharmaceutically useful IDO1 inhibitors.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
JournalBioorganic and medicinal chemistry letters
Volume23
Issue number1
Early online date24 Nov 2012
DOIs
Publication statusPublished - 1 Jan 2013
EventJFB 2011. - Liege, Belgium
Duration: 19 May 2011 → …

Keywords

  • Cancer immunology
  • Indoleamine 2,3-dioxygenase
  • Molecular modeling
  • Pyrroloiminoquinones
  • Tsitsikammamines

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  • Projects

    CANTOL: Design and synthesis of indolamine dioxygenase (IDO) for the treatment of cancer

    MASEREEL, B., WOUTERS, J., Dolušić, E., FREDERICK, R., POUYEZ, J., Van den Eynde, B. J., Frère, J., Moser, M., Jean-Marie, B., Combalbert, J. & Stephenne, J.

    1/04/0831/03/12

    Project: Research

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    • 5 Participation in conference

    47th RICT: Drug Discovery and Selection.

    Eduard Dolusic (Poster)

    6 Jul 20118 Jul 2011

    Activity: Participating in or organising an event typesParticipation in conference

    JFB 2011.

    Eduard Dolusic (Speaker)

    19 May 201120 May 2011

    Activity: Participating in or organising an event typesParticipation in conference

    XVIIIeme JOURNEE JEUNES CHERCHEURS

    Eduard Dolusic (Poster)

    4 Feb 2011

    Activity: Participating in or organising an event typesParticipation in conference

    Cite this

    Dolusic, E., Larrieu, P., Meinguet, C., Colette, D., Rives, A., Blanc, S., Ferain, T., Pilotte, L., Stroobant, V., Wouters, J., Van den Eynde, B., Masereel, B., Delfourne, E., & Frédérick, R. (2013). Indoleamine 2,3-Dioxygenase Inhibitory Activity of Derivatives of Marine Alkaloid Tsitsikammamine A. Bioorganic and medicinal chemistry letters, 23(1), 47-54. https://doi.org/10.1016/j.bmcl.2012.11.036