Indoleamine 2,3-dioxygenase inhibitors: a patent review (2008-2012)

E. Dolušić, R. Frédérick

Research output: Contribution to journalLiterature review

Abstract

Introduction: The inhibition of indoleamine 2,3-dioxygenase (IDO) has emerged as a key area in cancer immunotherapy in the past decade. Despite the large variety of potential inhibitors screened so far, the number of active scaffolds remains limited. Areas covered: All relevant patent literature published between 2008 and 2012 is reviewed. Representative examples are given for each patent and/or class of compounds along with data (if available) on their inhibitory activity. The presentation is deepened by additional data published in peer-reviewed literature. Expert opinion: Key events that stimulated the search of IDO inhibitors are presented. To date, however, the number of available scaffolds remains limited with only one confirmed inhibitor (from Incyte Corp.) in the clinic. Major challenges in the search for IDO inhibitors are discussed as well as the relevance of selectivity of IDO inhibition versus inhibition of tryptophan 2,3-dioxygenase. © 2013 Informa UK, Ltd.
Original languageEnglish
Pages (from-to)1367-1381
Number of pages15
JournalExpert opinion on therapeutic targets
Volume23
Issue number10
DOIs
Publication statusPublished - 1 Oct 2013

Keywords

  • cancer, immunotherapy, indoleamine 2,3-dioxygenase, patent review

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  • Projects

    CANTOL: Design and synthesis of indolamine dioxygenase (IDO) for the treatment of cancer

    MASEREEL, B., WOUTERS, J., Dolušić, E., FREDERICK, R., POUYEZ, J., Van den Eynde, B. J., Frère, J., Moser, M., Jean-Marie, B., Combalbert, J. & Stephenne, J.

    1/04/0831/03/12

    Project: Research

    Activities

    • 4 Participation in conference

    ASMC11 (4th International Symposium on Advances in Synthetic and Medicinal Chemistry).

    Eduard Dolusic (Poster)

    21 Aug 201125 Aug 2011

    Activity: Participating in or organising an event typesParticipation in conference

    47th RICT: Drug Discovery and Selection.

    Eduard Dolusic (Poster)

    6 Jul 20118 Jul 2011

    Activity: Participating in or organising an event typesParticipation in conference

    JFB 2011.

    Eduard Dolusic (Speaker)

    19 May 201120 May 2011

    Activity: Participating in or organising an event typesParticipation in conference

    Student Theses

    Synthèse d'inhibiteurs d'indoleamine-2,3-dioxygenases (IDO et TDO) deux enzymes dont les propriétés immunosuppressives en font des cibles majeures pour le traitement du cancer

    Author: Modaffari, S., 2010

    Supervisor: Frederick, R. (Supervisor) & Dolusic, E. (Jury)

    Student thesis: Master typesMaster in Chemistry

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