Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

E. Dolušić, P. Larrieu, S. Blanc, F. Sapunaric, J. Pouyez, L. Moineaux, D. Colette, V. Stroobant, L. Pilotte, D. Colau, Thierry Ferain, G. Fraser, M. Galleni, Jean-Marie Frère, B. Masereel, B. Van Den Eynde, J. Wouters, R. Frédérick

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

Indoleamine 2,3-dioxygenase (IDO) is an important new therapeutic target for the treatment of cancer. With the aim of discovering novel IDO inhibitors, a virtual screen was undertaken and led to the discovery of the keto-indole derivative 1a endowed with an inhibitory potency in the micromolar range. Detailed kinetics were performed and revealed an uncompetitive inhibition profile. Preliminary SARs were drawn in this series and corroborated the putative binding orientation as suggested by docking. © 2011 Elsevier Masson SAS. All rights reserved.
langue originaleAnglais
Pages (de - à)3058-3065
Nombre de pages8
journalEuropean Journal of Medicinal Chemistry
Volume46
Numéro de publication7
Les DOIs
étatPublié - 2011

Empreinte digitale

Indoleamine-Pyrrole 2,3,-Dioxygenase
Indoles
Derivatives
Kinetics
Neoplasms
Therapeutics
indole

Citer ceci

Dolušić, E. ; Larrieu, P. ; Blanc, S. ; Sapunaric, F. ; Pouyez, J. ; Moineaux, L. ; Colette, D. ; Stroobant, V. ; Pilotte, L. ; Colau, D. ; Ferain, Thierry ; Fraser, G. ; Galleni, M. ; Frère, Jean-Marie ; Masereel, B. ; Van Den Eynde, B. ; Wouters, J. ; Frédérick, R. / Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. Dans: European Journal of Medicinal Chemistry. 2011 ; Vol 46, Numéro 7. p. 3058-3065.
@article{f8521be13e94480e9c3532f021263efc,
title = "Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors",
abstract = "Indoleamine 2,3-dioxygenase (IDO) is an important new therapeutic target for the treatment of cancer. With the aim of discovering novel IDO inhibitors, a virtual screen was undertaken and led to the discovery of the keto-indole derivative 1a endowed with an inhibitory potency in the micromolar range. Detailed kinetics were performed and revealed an uncompetitive inhibition profile. Preliminary SARs were drawn in this series and corroborated the putative binding orientation as suggested by docking. {\circledC} 2011 Elsevier Masson SAS. All rights reserved.",
keywords = "enzyme inhibitors, keto-indoles, Structure-activity relationships, Structure-based drug discovery, IDO, Indoleamine 2 3-dioxygenase",
author = "E. Dolušić and P. Larrieu and S. Blanc and F. Sapunaric and J. Pouyez and L. Moineaux and D. Colette and V. Stroobant and L. Pilotte and D. Colau and Thierry Ferain and G. Fraser and M. Galleni and Jean-Marie Fr{\`e}re and B. Masereel and {Van Den Eynde}, B. and J. Wouters and R. Fr{\'e}d{\'e}rick",
year = "2011",
doi = "10.1016/j.ejmech.2011.02.049",
language = "English",
volume = "46",
pages = "3058--3065",
journal = "European journal of medicinal chemistry / Chimica therapeutica",
issn = "0223-5234",
publisher = "Elsevier Masson SAS",
number = "7",

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Dolušić, E, Larrieu, P, Blanc, S, Sapunaric, F, Pouyez, J, Moineaux, L, Colette, D, Stroobant, V, Pilotte, L, Colau, D, Ferain, T, Fraser, G, Galleni, M, Frère, J-M, Masereel, B, Van Den Eynde, B, Wouters, J & Frédérick, R 2011, 'Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors', European Journal of Medicinal Chemistry, VOL. 46, Numéro 7, p. 3058-3065. https://doi.org/10.1016/j.ejmech.2011.02.049

Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. / Dolušić, E.; Larrieu, P.; Blanc, S.; Sapunaric, F.; Pouyez, J.; Moineaux, L.; Colette, D.; Stroobant, V.; Pilotte, L.; Colau, D.; Ferain, Thierry; Fraser, G.; Galleni, M.; Frère, Jean-Marie; Masereel, B.; Van Den Eynde, B.; Wouters, J.; Frédérick, R.

Dans: European Journal of Medicinal Chemistry, Vol 46, Numéro 7, 2011, p. 3058-3065.

Résultats de recherche: Contribution à un journal/une revueArticle

TY - JOUR

T1 - Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

AU - Dolušić, E.

AU - Larrieu, P.

AU - Blanc, S.

AU - Sapunaric, F.

AU - Pouyez, J.

AU - Moineaux, L.

AU - Colette, D.

AU - Stroobant, V.

AU - Pilotte, L.

AU - Colau, D.

AU - Ferain, Thierry

AU - Fraser, G.

AU - Galleni, M.

AU - Frère, Jean-Marie

AU - Masereel, B.

AU - Van Den Eynde, B.

AU - Wouters, J.

AU - Frédérick, R.

PY - 2011

Y1 - 2011

N2 - Indoleamine 2,3-dioxygenase (IDO) is an important new therapeutic target for the treatment of cancer. With the aim of discovering novel IDO inhibitors, a virtual screen was undertaken and led to the discovery of the keto-indole derivative 1a endowed with an inhibitory potency in the micromolar range. Detailed kinetics were performed and revealed an uncompetitive inhibition profile. Preliminary SARs were drawn in this series and corroborated the putative binding orientation as suggested by docking. © 2011 Elsevier Masson SAS. All rights reserved.

AB - Indoleamine 2,3-dioxygenase (IDO) is an important new therapeutic target for the treatment of cancer. With the aim of discovering novel IDO inhibitors, a virtual screen was undertaken and led to the discovery of the keto-indole derivative 1a endowed with an inhibitory potency in the micromolar range. Detailed kinetics were performed and revealed an uncompetitive inhibition profile. Preliminary SARs were drawn in this series and corroborated the putative binding orientation as suggested by docking. © 2011 Elsevier Masson SAS. All rights reserved.

KW - enzyme inhibitors

KW - keto-indoles

KW - Structure-activity relationships

KW - Structure-based drug discovery

KW - IDO

KW - Indoleamine 2 3-dioxygenase

UR - http://www.scopus.com/inward/record.url?scp=79957472526&partnerID=8YFLogxK

U2 - 10.1016/j.ejmech.2011.02.049

DO - 10.1016/j.ejmech.2011.02.049

M3 - Article

VL - 46

SP - 3058

EP - 3065

JO - European journal of medicinal chemistry / Chimica therapeutica

JF - European journal of medicinal chemistry / Chimica therapeutica

SN - 0223-5234

IS - 7

ER -