Design and synthesis of indolamine dioxygenase (IDO) for the treatment of cancer

Project: Research

Project Details

Description

This project is a drug discovery program aimed at finding new chemical entities capable of inhibiting the immunosuppression mediated by indoleamine 2,3-dioxygenase (IDO) expression in tumors. The project also encompasses a phase I/II clinical trial with a first-generation IDO inhibitor, and a diagnostic application leading to the development of new diagnostic test for detecting IDO-positive cancers.
AcronymCANTOL
StatusFinished
Effective start/end date1/04/0831/03/12

Keywords

  • molecular design
  • medicinal chemistry
  • enzymology

Research Output

  • 7 Poster
  • 4 Article
  • 3 Literature review
  • 1 Conference contribution

Indoleamine 2,3-dioxygenase inhibitors: a patent review (2008-2012)

Dolušić, E. & Frédérick, R., 1 Oct 2013, In : Expert opinion on therapeutic targets. 23, 10, p. 1367-1381 15 p.

Research output: Contribution to journalLiterature review

  • Indoleamine 2,3-Dioxygenase Inhibitory Activity of Derivatives of Marine Alkaloid Tsitsikammamine A

    Dolusic, E., Larrieu, P., Meinguet, C., Colette, D., Rives, A., Blanc, S., Ferain, T., Pilotte, L., Stroobant, V., Wouters, J., Van den Eynde, B., Masereel, B., Delfourne, E. & Frédérick, R., 1 Jan 2013, In : Bioorganic and medicinal chemistry letters. 23, 1, p. 47-54 8 p.

    Research output: Contribution to journalArticle

  • 3 Downloads (Pure)

    Convenient one-pot formation of highly functionalized 5-halothiazoles

    Dolusic, E., Modaffari, S., Pochet, L., Wouters, J., Masereel, B. & Frédérick, R., 1 Jul 2012, p. Book of Abstracts, Balticum Organicum Syntheticum, July 1-4 2012, Tallinn, Estonia, PO27, p. 74. 1 p.

    Research output: Contribution to conferencePoster

    Open Access
    File
  • Activities

    • 7 Participation in conference

    Balticum Organicum Syntheticum 2012

    Eduard Dolusic (Poster)
    1 Jul 2012

    Activity: Participating in or organising an event typesParticipation in conference

    15th SIGMA-ALDRICH Organic Synthesis Meeting

    Eduard Dolusic (Poster)
    1 Dec 20112 Dec 2011

    Activity: Participating in or organising an event typesParticipation in conference

    47th RICT: Drug Discovery and Selection.

    Eduard Dolusic (Poster)
    6 Jul 20118 Jul 2011

    Activity: Participating in or organising an event typesParticipation in conference