Projects per year
Personal profile
Diplomas
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Targeted covalent probes to interfere with homomeric proteinprotein interactions: inhibition of lactate dehydrogenase (LDH) through covalent modification of key amino acids
Garcia Llinas, X. (PI), Pochet, L. (Supervisor) & Wouters, J. (CoI)
1/10/24 → 30/09/26
Project: Research
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Acquisition of an elemental analyser for the qualitative and quantitative analysis of organic substances
Pirotte, B. (PI), Delaude, L. (CoPI), MONBALIU, J.-C. M. (CoPI), Richel, A. (CoPI) & Pochet, L. (CoPI)
1/01/24 → 31/12/25
Project: Research
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Structure-based drug design and synthesis of selective smallmolecular- weight inhibitors of FXIIa, an attractive target from the intrinsic coagulation cascade
TRAINA, A. (PI), Lanners, S. (Supervisor) & Pochet, L. (CoI)
1/10/22 → 31/12/24
Project: Research
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THROMBO: Enzymologic, mechanistic and pharmacological study of specific inhibitors of serine proteases implicated in hemostasis disorders
Pochet, L. (PI), Dogne, J.-M. (CoI), Masereel, B. (CoI) & ROBERT, S. (Researcher)
1/09/04 → …
Project: PHD
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Targeted covalent probes to interfere with homomeric proteinprotein interactions: inhibition of Mycobacterium tuberculosis serine phosphatase through covalent modification of key amino acids
Garcia Llinas, X. (PI), Pochet, L. (Supervisor) & Wouters, J. (CoI)
1/10/22 → 30/09/24
Project: Research
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Investigation of the inhibition mechanism of coumarins on chymotrypsin by mass spectrometry
Pochet, L., Dieu, M., Frédérick, R., Murray, A.-M., Kempen, I., Pirotte, B. & Masereel, B., 2003, In: Tetrahedron. 59, p. 4557-4561 5 p.Research output: Contribution to journal › Article › peer-review
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Online magnetic bead based dynamic protein affinity selection coupled to LC-MS for the screening of acetylcholine binding protein ligands
Pochet, L., Heus, F., Jonker, N., Lingeman, H., Niessen, W. M. A., Kool, J. & Smit, A. B., 15 Jun 2011, In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 20, p. 1781-1788 8 p.Research output: Contribution to journal › Article › peer-review
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Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors
Robert, S., Bertolla, C., Masereel, B., Dogné, J.-M. & Pochet, L., 2008, In: Journal of Medicinal Chemistry. 51, p. 3077-3081 5 p.Research output: Contribution to journal › Article › peer-review
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Coumarins as factor XIIa inhibitors: Potency and selectivity improvements using a fragment-based strategy
Davoine, C., Traina, A., Evrard, J., Lanners, S., Fillet, M. & Pochet, L., 5 Nov 2023, In: European Journal of Medicinal Chemistry. 259, 115636.Research output: Contribution to journal › Article › peer-review
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Capillary electrophoresis as a fragment screening tool to cross-validate hits from chromogenic assay: Application to FXIIa
Davoine, C., Fillet, M. & Pochet, L., 1 May 2021, In: Talanta. 226, p. 122163 122163.Research output: Contribution to journal › Article › peer-review
Datasets
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CCDC 1851262: Experimental Crystal Structure Determination
Prevost, J. R. C. (Creator), Kozlova, A. (Creator), Saadi, B. E. (Contributor), Yildiz, E. (Creator), Modaffari, S. (Contributor), Lambert, D. M. (Creator), Pochet, L. (Contributor), Wouters, J. (Contributor), Dolušić, E. (Contributor) & Frédérick, R. (Contributor), University of Namur, 5 Dec 2018
DOI: 10.5517/ccdc.csd.cc204d4q, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc204d4q&sid=DataCite
Dataset
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CCDC 1851263: Experimental Crystal Structure Determination
Prevost, J. R. C. (Creator), Kozlova, A. (Creator), Saadi, B. E. (Contributor), Yildiz, E. (Creator), Modaffari, S. (Contributor), Lambert, D. M. (Creator), Pochet, L. (Contributor), Wouters, J. (Contributor), Dolušić, E. (Contributor) & Frédérick, R. (Contributor), University of Namur, 5 Dec 2018
DOI: 10.5517/ccdc.csd.cc204d5r, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc204d5r&sid=DataCite
Dataset
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CCDC 1980941: Experimental Crystal Structure Determination
Ameryckx, A. (Creator), Pochet, L. (Contributor), Wang, G. (Creator), Yildiz, E. (Creator), Saadi, B. E. (Contributor), Wouters, J. (Contributor), Van Bambeke, F. (Creator) & Frédérick, R. (Contributor), University of Namur, 15 Aug 2020
DOI: 10.5517/ccdc.csd.cc24hbbb, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc24hbbb&sid=DataCite
Dataset
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CCDC 1980940: Experimental Crystal Structure Determination
Ameryckx, A. (Creator), Pochet, L. (Contributor), Wang, G. (Creator), Yildiz, E. (Creator), Saadi, B. E. (Contributor), Wouters, J. (Contributor), Van Bambeke, F. (Creator) & Frédérick, R. (Contributor), University of Namur, 15 Aug 2020
DOI: 10.5517/ccdc.csd.cc24hb99, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc24hb99&sid=DataCite
Dataset
Thesis
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Conception, synthèse et évaluation biologique de coumarines en tant qu'inhibiteurs de protéases à sérine
Pochet, L. (Author)Masereel, B. (Supervisor), 2000Student thesis: Doc types › Doctor of Sciences
Press/Media
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Findings from Catholic University Louvain (UCLouvain) in Factor Xa Inhibitors Reported (In vitro assessment of the risk of ABCB1-mediated drug-drug interaction between rivaroxaban and tacrolimus in human embryonic kidney 293 recombinant cell ...)
26/08/24
1 item of Media coverage
Press/Media: Expert Comment
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Findings from University of Liege in the Area of Technology Reported (Advances In Analytical Technologies Detecting and Characterizing Noncovalent Interactions for Fragment-based Drug Discovery)
4/09/23
1 item of Media coverage
Press/Media: Expert Comment
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AVANCÉE SIGNIFICATIVE DANS LE TRAITEMENT DU CANCER
Dolusic, E., Frederick, R., Masereel, B., Wouters, J., Moineaux, L. & Pochet, L.
2/02/12
1 item of Media coverage
Press/Media: Research