Cyproterone and a comparison with its acetate ester

Jérôme De Ruyck, Sandrine Henry De Hassonville, Jean François Liégeois, Johan Wouters

Research output: Contribution to journalArticle

Abstract

The crystal structure of cyproterone (systematic name: 6-chloro-1,2- dihydro-17-hydroxy-3′H-cyclopropa[a]pregna-1,4,6-triene-3,20-dione), C22H27ClO3, is compared with cyproterone acetate, a potent anti-androgen steroid. The two compounds adopt a similar conformation, except for the cyclopropyl ring attached to the cyclohexenone ring (ring A). Cyproterone further adopts a crystal packing distinct from that of the acetate form. These differences result from hydrogen bonding between the free hydroxy group and the carbonyl group of ring A.

Original languageEnglish
JournalActa Crystallographica Section E
Volume61
Issue number11
DOIs
Publication statusPublished - 1 Nov 2005

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