TY - JOUR
T1 - Cyproterone and a comparison with its acetate ester
AU - De Ruyck, Jérôme
AU - De Hassonville, Sandrine Henry
AU - Liégeois, Jean François
AU - Wouters, Johan
PY - 2005/11/1
Y1 - 2005/11/1
N2 - The crystal structure of cyproterone (systematic name: 6-chloro-1,2- dihydro-17-hydroxy-3′H-cyclopropa[a]pregna-1,4,6-triene-3,20-dione), C22H27ClO3, is compared with cyproterone acetate, a potent anti-androgen steroid. The two compounds adopt a similar conformation, except for the cyclopropyl ring attached to the cyclohexenone ring (ring A). Cyproterone further adopts a crystal packing distinct from that of the acetate form. These differences result from hydrogen bonding between the free hydroxy group and the carbonyl group of ring A.
AB - The crystal structure of cyproterone (systematic name: 6-chloro-1,2- dihydro-17-hydroxy-3′H-cyclopropa[a]pregna-1,4,6-triene-3,20-dione), C22H27ClO3, is compared with cyproterone acetate, a potent anti-androgen steroid. The two compounds adopt a similar conformation, except for the cyclopropyl ring attached to the cyclohexenone ring (ring A). Cyproterone further adopts a crystal packing distinct from that of the acetate form. These differences result from hydrogen bonding between the free hydroxy group and the carbonyl group of ring A.
UR - http://www.scopus.com/inward/record.url?scp=33144466968&partnerID=8YFLogxK
U2 - 10.1107/S1600536805031673
DO - 10.1107/S1600536805031673
M3 - Article
AN - SCOPUS:33144466968
SN - 1600-5368
VL - 61
JO - Acta crystallographica. Section E: Structure reports
JF - Acta crystallographica. Section E: Structure reports
IS - 11
ER -