Johan Wouters

2024

A Semiflexible Tetrahydrazone Macrocycle for Binding of Pyrophosphate and Smaller Anions

Halgreen, L., Torres-Huerta, A., Norvaisa, K., De Leener, G., Tumanov, N., Wouters, J., Bartik, K. & Valkenier, H., 17 May 2024, In: Journal of Organic Chemistry. 89, 10, p. 6853-6864 12 p.

Research output: Contribution to journal › Article › peer-review

Centrosymmetric homo- and heteroleptic core paddle-wheel copper(II) carboxylates; Syntheses, crystal structures, antioxidant, anticancer and enzyme inhibition activity

Viola, Khan, I. N., Muhammad, N., Shaik, M. R., Ahmad, A., Tumanov, N., Wouters, J., Ilyas, M. & Ibrahim, M., 5 Oct 2024, In: Journal of molecular structure. 1313, 138742.

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Design, physicochemical confirmation, single crystal structures as well as exploration of antibacterial and anticancer potential of organotin(IV) carboxylates

Gul, R., Muhammad, N., Sirajuddin, M., Noor, A., Tumanov, N., Wouters, J., Chafik, A., Solak, K., Mavi, A., Shujah, S., Ali, S., Khan, G. S. & Qayyum, S., 15 Mar 2024, In: Journal of molecular structure. 1300, 137306.

Research output: Contribution to journal › Article › peer-review

Regulating iminophosphorane P=N bond reactivity through geometric constraints with cage-shaped triarylphosphines

Chakraborty, S., Hu, L., Tumanov, N., Wouters, J., Robiette, R. & Berionni, G., 18 Jun 2024, Chemical Communications, 60, 55, p. 7073-7076 4 p.

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Using the nature of the achiral solvent to orient chiral resolution

de Meester, J., Shemchuk, O., Collard, L., Wouters, J., Baillieux, S., Robeyns, K. & Leyssens, T., 15 Mar 2024, In: CrystEngComm. 26, 15, p. 2056-2059 4 p.

Research output: Contribution to journal › Article › peer-review

2023

A morpheein equilibrium regulates catalysis in phosphoserine phosphatase SerB2 from Mycobacterium tuberculosis

Pierson, E., De Pol, F., Fillet, M. & Wouters, J., 10 Oct 2023, In: Communications Biology. 6, 1, 1024.

Research output: Contribution to journal › Article › peer-review

Open Access

A Selenenium-Bridged 10-Boratriptycene Lewis Acid

Osi, A., Tumanov, N., Wouters, J., Chardon, A. & Berionni, G., 19 Jan 2023, In: Synthesis. 55, 2, p. 347-353 7 p.

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Association of Pyramidal Boron Lewis Superacids with Pyridines: Bending 2,4,6-Collidine with the 10-Sulfonium-9-boratriptycene

OSI, A., Niessen, N., Mahaut, D., Champagne, B., Chardon, A., Tumanov, N., Berionni, G. & Wouters, J., 2 May 2023, In: Zeitschrift fuer Anorganische und Allgemeine Chemie. 649, 9-10, e202300009.

Research output: Contribution to journal › Article › peer-review

Diols Speed Up Guanidine Base Catalyzed Claisen-Schmidt Condensation to Produce New 15-Arylidene Steroids

Ispán, D., Küzdő, Á., Fonyó, M., Gömöry, Á., Tumanov, N., Wouters, J., Mahó, S., Lendvay, G. & Skoda-Földes, R., 6 Sept 2023, In: European Journal of Organic Chemistry. 26, 34, e202300560.

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From Proton to Boron: The Lewis Analogs of Protonated Brønsted Super Acids

OSI, A., Tumanov, N., Fusaro, L., Wouters, J., Berionni, G. & Chardon, A., 6 Jul 2023, In: Chemistry: A European Journal. 29, 38, e202301146.

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Guest exchange in a biomimetic Zn^II cavity-complex: kinetic control by a catalytic water, through pore selection, 2nd sphere assistance, and induced-fit processes

Nyssen, N., Giraud, N., Wouters, J., Jabin, I., Leherte, L. & Reinaud, O., 9 Aug 2023, In: Inorganic Chemistry Frontiers. 10, 19, p. 5772-5781 10 p.

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Human indoleamine-2,3-dioxygenase 2 cofactor lability and low substrate affinity explained by homology modeling, molecular dynamics and molecular docking

Mirgaux, M., Leherte, L. & Wouters, J., 2023, In: Journal of Biomolecular Structure & Dynamics. 42, 9, p. 4475-4488 14 p.

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Salt and Cocrystals Combining Sulfathiazole with Pyrimethamine

Bodart, L., Body, J., Tumanov, N., Leyssens, T. & Wouters, J., 1 Nov 2023, In: Crystal Growth and Design. 23, 11, p. 7811-7820 10 p.

Research output: Contribution to journal › Article › peer-review

Single crystal formation in core-shell capsules

Mettler, M., Dewandre, A., Tumanov, N., Wouters, J. & Septavaux, J., 6 Oct 2023, In: Chemical Communications. 59, 85, p. 12739-12742 4 p.

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Open Access

Targeting the phosphoserine phosphatase MtSerB2 for tuberculosis drug discovery, an hybrid knowledge based /fragment based approach

Haufroid, M., Volkov, A. N. & Wouters, J., 5 Jan 2023, In: European Journal of Medicinal Chemistry. 245, 114935.

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The Facile Hydrolysis of Imidazolinium Chlorides (N-Heterocyclic Carbene Precursors) Under Basic Aqueous Conditions

Touj, N., Taping, J. J., Tumanov, N., Wouters, J. & Delaude, L., 1 Dec 2023, In: Chemistry: A European Journal. 29, 67, e202302402.

Research output: Contribution to journal › Article › peer-review

2022

Antimicrobial Activity of a Repurposed Harmine-Derived Compound on Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates

Breine, A., Van Gysel, M., Elsocht, M., Whiteway, C., Philippe, C., Quinet, T., Valcek, A., Wouters, J., Ballet, S. & Van der Henst, C., 24 Jan 2022, In: Frontiers in cellular and infection microbiology. 11, 789672.

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Balancing fluorescence and singlet oxygen formation in push-pull type near-infrared BODIPY photosensitizers

Deckers, J., Cardeynaels, T., Doria, S., Tumanov, N., Lapini, A., Ethirajan, A., Ameloot, M., Wouters, J., Di Donato, M., Champagne, B. & Maes, W., 6 Jun 2022, In: Journal of Materials Chemistry C. 10, 24, p. 9344-9355 12 p.

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Calix[6]arenes with halogen bond donor groups as selective and efficient anion transporters

Singh, A., Torres-Huerta, A., Vanderlinden, T., Renier, N., Martínez-Crespo, L., Tumanov, N., Wouters, J., Bartik, K., Jabin, I. & Valkenier, H., 6 May 2022, In: Chemical Communications. 58, 42, p. 6255-6258 4 p.

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Classroom experiments with artificial sweeteners: Growing single crystals and simple calorimetry

Wouters, J., Van Meervelt, L. & Parkin, S., 1 Sept 2022, In: Acta Crystallographica. Section E: Crystallographic Communications. 78, Pt 9, p. 874-879 6 p.

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Discovery of small molecules interacting at lactate dehydrogenases tetrameric interface using a biophysical screening cascade

Thabault, L., Brustenga, C., Savoyen, P., Van Gysel, M., Wouters, J., Sonveaux, P., Frédérick, R. & Liberelle, M., 15 Feb 2022, In: European Journal of Medicinal Chemistry. 230, 114102.

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Structural study of bioisosteric derivatives of 5-(1 H-indol-3-yl)-benzotriazole and their ability to form chalcogen bonds

Mirgaux, M., Scaillet, T., Kozlova, A., Tumanov, N., Frédérick, R., Bodart, L. & Wouters, J., 1 Apr 2022, In: Acta Crystallographica. Section E: Crystallographic Communications. 78, 4, p. 418-424 7 p.

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Synthesis, Characterization, Biological Activity and Molecular Docking Studies of Novel Organotin(IV) Carboxylates

Muhammad, N., Ahmad, M., Sirajuddin, M., Ali, Z., Tumanov, N., Wouters, J., Chafik, A., Solak, K., Mavi, A., Muhammad, S., Shujah, S., Ali, S. & Al-Sehemi, A. G., 5 Apr 2022, In: Frontiers in Pharmacology. 13, 864336.

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Open Access

Synthesis of Novel Ferrocene-Benzofuran Hybrids via Palladium- and Copper-Catalyzed Reactions

Nagy, E., Váradi, M., Nagymihály, Z., Kollár, L., Kovács, K., Andreidesz, K., Gömöry, Á., Tumanov, N., Wouters, J. & Skoda-Földes, R., 11 Nov 2022, In: Inorganics. 10, 11, p. 205 16 p., 205.

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Taming the Lewis Superacidity of Non-Planar Boranes: C−H Bond Activation and Non-Classical Binding Modes at Boron

Osi, A., Mahaut, D., Tumanov, N., Fusaro, L., Wouters, J., Champagne, B., Chardon, A. & Berionni, G., 7 Feb 2022, In: Angewandte Chemie. International edition. 61, 7, e202112342.

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2021

Aconitate decarboxylase 1 participates in the control of pulmonary Brucella infection in mice

Demars, A., Vitali, A., Comein, A., Carlier, E., Azouz, A., Goriely, S., Smout, J., Flamand, V., Van Gysel, M., Wouters, J., Abendroth, J., Edwards, T. E., Machelart, A., Hoffmann, E., Brodin, P., De Bolle, X. & Muraille, E., Sept 2021, In: Plos Pathogens. 17, 9, p. e1009887 e1009887.

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Copper(ii) complexes with tridentate halogen-substituted Schiff base ligands: synthesis, crystal structures and investigating the effect of halogenation, leaving groups and ligand flexibility on antiproliferative activities

Kordestani, N., Amiri Rudbari, H., Fernandes, A. R., Raposo, L. R., Luz, A., Baptista, P. V., Bruno, G., Scopelliti, R., Fateminia, Z., Micale, N., Tumanov, N., Wouters, J., Abbasi Kajani, A. & Bordbar, A. K., 21 Mar 2021, In: Dalton Transactions. 50, 11, p. 3990-4007 18 p.

Research output: Contribution to journal › Article › peer-review

Discovery of a novel lactate dehydrogenase tetramerization domain using epitope mapping and peptides

Thabault, L., Liberelle, M., Koruza, K., Yildiz, E., Joudiou, N., Messens, J., Brisson, L., Wouters, J., Sonveaux, P. & Frédérick, R., 1 Jan 2021, In: The Journal of Biological Chemistry. 296, 100422.

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Open Access

Heteroleptic enantiopure Pd(ii)-complexes derived from halogen-substituted Schiff bases and 2-picolylamine: Synthesis, experimental and computational characterization and investigation of the influence of chirality and halogen atoms on the anticancer activity

Kordestani, N., Amiri Rudbari, H., Correia, I., Valente, A., Côrte-Real, L., Islam, M. K., Micale, N., Braun, J. D., Herbert, D. E., Tumanov, N., Wouters, J. & Enamullah, M., 28 May 2021, In: New Journal of Chemistry. 45, 20, p. 9163-9180 18 p.

Research output: Contribution to journal › Article › peer-review

Key amino acid residues in homoserine-acetyltransferase from M. tuberculosis give insight into the evolution of MetX family of enzymes – HAT, SAT and HST

Maurya, B., Colaço, M., Wouters, J., Pochet, L. & Misquith, S., Oct 2021, In: Biochimie. 189, p. 13-25 13 p.

Research output: Contribution to journal › Article › peer-review

Sterically hindered ortho-substituted phosphatriptycenes as configurationally stable P-chirogenic triarylphosphines

Hu, L., Mahaut, D., Tumanov, N., Wouters, J., Collard, L., Robiette, R. & Berionni, G., 14 Apr 2021, In: Dalton Transactions. 50, 14, p. 4772-4777 6 p.

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Structure and dynamics of an archeal monoglyceride lipase from Palaeococcus ferrophilus as revealed by crystallography and in silico analysis

Labar, G., Brandt, N., Flaba, A., Wouters, J. & Leherte, L., Apr 2021, In: Biomolecules. 11, 4, 22 p., 533.

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Synthesis of Azolium-2-dithiocarboxylate Zwitterions under Mild, Aerobic Conditions

Mazars, F., Hrubaru, M., Tumanov, N., Wouters, J. & Delaude, L., 8 Apr 2021, In: European Journal of Organic Chemistry. 2021, 13, p. 2025-2033 9 p.

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Taking advantage of solvate formation to modulate drug-drug ratio in clofaziminium diclofenac salts

Bodart, L., Prinzo, M., Derlet, A., Tumanov, N. & Wouters, J., 7 Jan 2021, In: CrystEngComm. 23, 1, p. 185-201 17 p.

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Temporary Intermediates of L-Trp Along the Reaction Pathway of human Indoleamine 2,3-dioxygenase 1 and Identification of an Exo Site

Mirgaux, M., Leherte, L. & Wouters, J., 15 Dec 2021, In: International Journal of Tryptophan Research. 14, p. 1- 11

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Triptycene Boronates, Boranes, and Boron Ate-Complexes: Toward Sterically Hindered Triarylboranes and Trifluoroborates

Gama, M., Antognini Silva, X., Doan, T. H., Osi, A., Chardon, A., Tumanov, N., Wouters, J. & Berionni, G., 5 Mar 2021, In: European Journal of Organic Chemistry. 2021, 9, p. 1440-1445 6 p.

Research output: Contribution to journal › Article › peer-review

2020

1,8,10-Trisubstituted anthracenyl hydrocarbons: Towards versatile scaffolds for multiple-H-bonded recognition arrays

Forensi, S., Stopin, A., de Leo, F., Wouters, J. & Bonifazi, D., 18 Dec 2020, In: Tetrahedron. 76, 51, 131299.

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A new potential anti-cancer beta-carboline derivative decreases the expression levels of key proteins involved in glioma aggressiveness: A proteomic investigation

Carvalho, A., Viaene, J., Vandenbussche, G., De Braekeleer, K., Masereel, B., Wouters, J., Souard, F., Vander Heyden, Y., Van Antwerpen, P., Delporte, C. & Mathieu, V., Feb 2020, In: Drug Development Research. 81, 1, p. 32-42 11 p.

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Open Access

Biochemical characterization of phosphoserine phosphatase SerB2 from Mycobacterium marinum

Pierson, E. & Wouters, J., 1 Oct 2020, In: Biochemical and Biophysical Research Communications. 530, 4, p. 739-744 6 p.

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Chiral Resolution of Mandelic Acid through Preferential Cocrystallization with Nefiracetam

Buol, X., Caro Garrido, C., Robeyns, K., Tumanov, N., Collard, L., Wouters, J. & Leyssens, T., 2 Dec 2020, In: Crystal Growth and Design. 20, 12, p. 7979-7988 10 p.

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Chiral Resolution of RS-Oxiracetam upon Cocrystallization with Pharmaceutically Acceptable Inorganic Salts

Shemchuk, O., Song, L., Tumanov, N., Wouters, J., Braga, D., Grepioni, F. & Leyssens, T., 1 Apr 2020, In: Crystal Growth and Design. 20, 4, p. 2602-2607 6 p.

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Open Access

Combining API in a dual-drug ternary cocrystal approach

Song, L., Robeyns, K., Tumanov, N., Wouters, J. & Leyssens, T., 7 Nov 2020, In: Chemical Communications. 56, 86, p. 13229-13232 4 p.

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Combining two antitubercular drugs, clofazimine and 4-aminosalicylic acid, in order to improve clofazimine aqueous solubility and 4-aminosalicylic acid thermal stability

Bodart, L., Derlet, A., Buol, X., Leyssens, T., Tumanov, N. & Wouters, J. (Supervisor), Dec 2020, In: Journal of Pharmaceutical Sciences. 109, 12, p. 3645-3652 8 p.

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Complex mineralogical-geochemical sequences and weathering events in the supergene ore of the Cu–Co Luiswishi deposit (Katanga, D.R. Congo)

Fontaine, L., De Putter, T., Bernard, A., Decrée, S., Cailteux, J., Wouters, J. & Yans, J., Jan 2020, In: Journal of African Earth Sciences. 161, 103674.

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