Design, physicochemical confirmation, single crystal structures as well as exploration of antibacterial and anticancer potential of organotin(IV) carboxylates

Roshni Gul; Niaz Muhammad; Muhammad Sirajuddin; Awal Noor; Nikolay Tumanov; Johan Wouters; Abdelbasset Chafik; Kübra Solak; Ahmet Mavi; Shaukat Shujah; Saqib Ali; Gul Shahzada Khan; Sadaf Qayyum

doi:10.1016/j.molstruc.2023.137306

Design, physicochemical confirmation, single crystal structures as well as exploration of antibacterial and anticancer potential of organotin(IV) carboxylates

Roshni Gul, Niaz Muhammad, Muhammad Sirajuddin, Awal Noor, Nikolay Tumanov, Johan Wouters, Abdelbasset Chafik, Kübra Solak, Ahmet Mavi, Shaukat Shujah, Saqib Ali, Gul Shahzada Khan, Sadaf Qayyum

Research output: Contribution to journal › Article › peer-review

Abstract

In this article, we are reporting a series of di-and tri-organotin(IV) carboxylate complexes (1–4) derived from the reaction of sodium-3-bromophenylacetate (NaL) with (CH₃)₂SnCl₂, (C₄H₉)₂SnCl₂, (CH₃)₃SnCl and (C₄H₉)₃SnCl in dried toluene while refluxing for 8 h. The desired organotin(IV) derivative were analyzed by elemental analyzer, FTIR, NMR and single crystal XRD. The antimicrobial data against the tested bacterial strains follow the order: 2 > 4 > 3 > 1 > HL. The anticancer potential of the synthesized compounds was evaluated against the lung cancer cell line (A549) and normal lung fibroblast cell line (MRC-5) and it was observed that 4 was the highly cytotoxic against A549 while HL and 1 showed no cytotoxicity against MRC-5, neither at lower or higher concentrations.

Original language	English
Article number	137306
Journal	Journal of molecular structure
Volume	1300
DOIs	https://doi.org/10.1016/j.molstruc.2023.137306
Publication status	Published - 15 Mar 2024

Keywords

Antibacterial
Anticancer
Carboxylates
Oragnotin
Single crystal
X-ray analysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.molstruc.2023.137306

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Gul, R., Muhammad, N., Sirajuddin, M., Noor, A., Tumanov, N., Wouters, J., Chafik, A., Solak, K., Mavi, A., Shujah, S., Ali, S., Khan, G. S., & Qayyum, S. (2024). Design, physicochemical confirmation, single crystal structures as well as exploration of antibacterial and anticancer potential of organotin(IV) carboxylates. Journal of molecular structure, 1300, Article 137306. https://doi.org/10.1016/j.molstruc.2023.137306

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title = "Design, physicochemical confirmation, single crystal structures as well as exploration of antibacterial and anticancer potential of organotin(IV) carboxylates",

abstract = "In this article, we are reporting a series of di-and tri-organotin(IV) carboxylate complexes (1–4) derived from the reaction of sodium-3-bromophenylacetate (NaL) with (CH3)2SnCl2, (C4H9)2SnCl2, (CH3)3SnCl and (C4H9)3SnCl in dried toluene while refluxing for 8 h. The desired organotin(IV) derivative were analyzed by elemental analyzer, FTIR, NMR and single crystal XRD. The antimicrobial data against the tested bacterial strains follow the order: 2 > 4 > 3 > 1 > HL. The anticancer potential of the synthesized compounds was evaluated against the lung cancer cell line (A549) and normal lung fibroblast cell line (MRC-5) and it was observed that 4 was the highly cytotoxic against A549 while HL and 1 showed no cytotoxicity against MRC-5, neither at lower or higher concentrations.",

keywords = "Antibacterial, Anticancer, Carboxylates, Oragnotin, Single crystal, X-ray analysis",

author = "Roshni Gul and Niaz Muhammad and Muhammad Sirajuddin and Awal Noor and Nikolay Tumanov and Johan Wouters and Abdelbasset Chafik and K{\"u}bra Solak and Ahmet Mavi and Shaukat Shujah and Saqib Ali and Khan, {Gul Shahzada} and Sadaf Qayyum",

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year = "2024",

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doi = "10.1016/j.molstruc.2023.137306",

language = "English",

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Gul, R, Muhammad, N, Sirajuddin, M, Noor, A, Tumanov, N , Wouters, J, Chafik, A, Solak, K, Mavi, A, Shujah, S, Ali, S, Khan, GS & Qayyum, S 2024, 'Design, physicochemical confirmation, single crystal structures as well as exploration of antibacterial and anticancer potential of organotin(IV) carboxylates', Journal of molecular structure, vol. 1300, 137306. https://doi.org/10.1016/j.molstruc.2023.137306

TY - JOUR

T1 - Design, physicochemical confirmation, single crystal structures as well as exploration of antibacterial and anticancer potential of organotin(IV) carboxylates

AU - Gul, Roshni

AU - Muhammad, Niaz

AU - Sirajuddin, Muhammad

AU - Noor, Awal

AU - Tumanov, Nikolay

AU - Wouters, Johan

AU - Chafik, Abdelbasset

AU - Solak, Kübra

AU - Mavi, Ahmet

AU - Shujah, Shaukat

AU - Ali, Saqib

AU - Khan, Gul Shahzada

AU - Qayyum, Sadaf

PY - 2024/3/15

Y1 - 2024/3/15

N2 - In this article, we are reporting a series of di-and tri-organotin(IV) carboxylate complexes (1–4) derived from the reaction of sodium-3-bromophenylacetate (NaL) with (CH3)2SnCl2, (C4H9)2SnCl2, (CH3)3SnCl and (C4H9)3SnCl in dried toluene while refluxing for 8 h. The desired organotin(IV) derivative were analyzed by elemental analyzer, FTIR, NMR and single crystal XRD. The antimicrobial data against the tested bacterial strains follow the order: 2 > 4 > 3 > 1 > HL. The anticancer potential of the synthesized compounds was evaluated against the lung cancer cell line (A549) and normal lung fibroblast cell line (MRC-5) and it was observed that 4 was the highly cytotoxic against A549 while HL and 1 showed no cytotoxicity against MRC-5, neither at lower or higher concentrations.

AB - In this article, we are reporting a series of di-and tri-organotin(IV) carboxylate complexes (1–4) derived from the reaction of sodium-3-bromophenylacetate (NaL) with (CH3)2SnCl2, (C4H9)2SnCl2, (CH3)3SnCl and (C4H9)3SnCl in dried toluene while refluxing for 8 h. The desired organotin(IV) derivative were analyzed by elemental analyzer, FTIR, NMR and single crystal XRD. The antimicrobial data against the tested bacterial strains follow the order: 2 > 4 > 3 > 1 > HL. The anticancer potential of the synthesized compounds was evaluated against the lung cancer cell line (A549) and normal lung fibroblast cell line (MRC-5) and it was observed that 4 was the highly cytotoxic against A549 while HL and 1 showed no cytotoxicity against MRC-5, neither at lower or higher concentrations.

KW - Antibacterial

KW - Anticancer

KW - Carboxylates

KW - Oragnotin

KW - Single crystal

KW - X-ray analysis

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U2 - 10.1016/j.molstruc.2023.137306

DO - 10.1016/j.molstruc.2023.137306

M3 - Article

AN - SCOPUS:85179881568

SN - 0022-2860

VL - 1300

JO - Journal of molecular structure

JF - Journal of molecular structure

M1 - 137306

ER -

Design, physicochemical confirmation, single crystal structures as well as exploration of antibacterial and anticancer potential of organotin(IV) carboxylates

Abstract

Keywords

UN SDGs

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Physical Chemistry and characterization(PC2)

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Design, physicochemical confirmation, single crystal structures as well as exploration of antibacterial and anticancer potential of organotin(IV) carboxylates

Abstract

Keywords

UN SDGs

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Physical Chemistry and characterization(PC2)

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