Discovery and optimization of indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2-3 dioxygenase (IDO), a promising target for anti-cancer immunotherapy.

Raphaël Frédérick; Sébastien Blanc; Pierre Larrieu; Laurence Moineaux; Delphine Colette; Graeme Fraser; Vincent Stroobant; Luc Pilotte; Didier Colaux; Johan Wouters; Bernard Masereel; Benoît Van den Eynde; Eduard Dolušić

Discovery and optimization of indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2-3 dioxygenase (IDO), a promising target for anti-cancer immunotherapy.

Raphaël Frédérick, Sébastien Blanc, Pierre Larrieu, Laurence Moineaux, Delphine Colette, Graeme Fraser, Vincent Stroobant, Luc Pilotte, Didier Colaux, Johan Wouters, Bernard Masereel, Benoît Van den Eynde, Eduard Dolušić

Research output: Contribution to journal › Literature review › peer-review

Original language	French
Pages (from-to)	181-182
Journal	Drugs of the future
Volume	35
Issue number	suppl A
Publication status	Published - 2010

5 Poster
5 Article
1 Conference contribution
1 Literature review
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- 1 Other contribution

Thiosemicarbazide, a fragment with promising indolamine-2,3-dioxygenase (IDO) inhibition properties
Serra, S., Moineaux, L., Vancraeynest, C., Masereel, B., Wouters, J., Pochet, L. & Frédérick, R., 23 Jul 2014, In: European Journal of Medicinal Chemistry. 82, p. 96-105 10 p.
Research output: Contribution to journal › Article › peer-review
Indoleamine 2,3-dioxygenase inhibitors: a patent review (2008-2012)
Dolušić, E. & Frédérick, R., 1 Oct 2013, In: Expert opinion on therapeutic targets. 23, 10, p. 1367-1381 15 p.
Research output: Contribution to journal › Literature review › peer-review
Indoleamine 2,3-Dioxygenase Inhibitory Activity of Derivatives of Marine Alkaloid Tsitsikammamine A
Dolušić, E., Larrieu, P., Meinguet, C., Colette, D., Rives, A., Blanc, S., Ferain, T., Pilotte, L., Stroobant, V., Wouters, J., Van Den Eynde, B., Masereel, B., Delfourne, E. & Frédérick, R., 1 Jan 2013, In: Bioorganic and medicinal chemistry letters. 23, 1, p. 47-54 8 p.
Research output: Contribution to journal › Article › peer-review
3 Downloads (Pure)

2 Finished

CANTOL: Design and synthesis of indolamine dioxygenase (IDO) for the treatment of cancer
MASEREEL, B., Wouters, J., Dolušić, E., FREDERICK, R., POUYEZ, J., Van den Eynde, B. J., Frère, J., Moser, M., Jean-Marie, B., Combalbert, J. & Stephenne, J.
1/04/08 → 31/03/12
Project: Research
Design, synthesis and study of enzyme modulators implicated in tryptophan metabolism and particularly in the kynurenin pathway
FREDERICK, R.
1/10/07 → 30/09/10
Project: Research

Physical Chemistry and characterization(PC2)
Johan Wouters (Manager) & Carmela Aprile (Manager)
Technological Platform Physical Chemistry and characterization
Facility/equipment: Technological Platform

4 Participation in conference

ASMC11 (4th International Symposium on Advances in Synthetic and Medicinal Chemistry).
Eduard Dolusic (Poster)
21 Aug 2011 → 25 Aug 2011
Activity: Participating in or organising an event types › Participation in conference
47th RICT: Drug Discovery and Selection.
Eduard Dolusic (Poster)
6 Jul 2011 → 8 Jul 2011
Activity: Participating in or organising an event types › Participation in conference
JFB 2011.
Eduard Dolusic (Speaker)
19 May 2011 → 20 May 2011
Activity: Participating in or organising an event types › Participation in conference

Conception, synthèse et étude d’inhibiteurs de la tryptophane 2,3-dioxygénase (TDO), une cible prometteuse pour le traitement du cancer
Author: Moineaux, L., 30 Jan 2012
Supervisor: Wouters, J. (Supervisor), Lanners, S. (President), Masereel, B. (Jury), Galleni, M. (External person) (Jury) & Frederick, R. (Jury)
Student thesis: Doc types › Doctor of Sciences

File
Rational design, synthesis, molecular modeling and evaluation of β-carboline and 5H-indeno[1,2-c]pyridazin-5-one derivatives as potential MAO and IDO inhibitors
Author: Reniers, J., 4 Oct 2011
Supervisor: Wouters, J. (Supervisor), Frederick, R. (Jury), Michiels, C. (Jury), Vincent, S. (President) & Kiss, R. (External person) (Jury)
Student thesis: Doc types › Doctor of Sciences

File
Synthèse d'inhibiteurs d'indoleamine-2,3-dioxygenases (IDO et TDO) deux enzymes dont les propriétés immunosuppressives en font des cibles majeures pour le traitement du cancer
Author: Modaffari, S., 2010
Supervisor: Frederick, R. (Supervisor) & Dolusic, E. (Jury)
Student thesis: Master types › Master in Chemistry

Cite this

Frédérick, R., Blanc, S., Larrieu, P., Moineaux, L., Colette, D., Fraser, G., Stroobant, V., Pilotte, L., Colaux, D., Wouters, J., Masereel, B., Van den Eynde, B., & Dolušić, E. (2010). Discovery and optimization of indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2-3 dioxygenase (IDO), a promising target for anti-cancer immunotherapy. Drugs of the future, 35(suppl A), 181-182.

@article{26b347ccac8a4ac19b3eeaa3b9c9fc9a,

title = "Discovery and optimization of indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2-3 dioxygenase (IDO), a promising target for anti-cancer immunotherapy.",

author = "Rapha{\"e}l Fr{\'e}d{\'e}rick and S{\'e}bastien Blanc and Pierre Larrieu and Laurence Moineaux and Delphine Colette and Graeme Fraser and Vincent Stroobant and Luc Pilotte and Didier Colaux and Johan Wouters and Bernard Masereel and {Van den Eynde}, Beno{\^i}t and Eduard Dolu{\v s}i{\'c}",

year = "2010",

language = "Fran{\c c}ais",

volume = "35",

pages = "181--182",

journal = "Drugs of the future",

issn = "0377-8282",

publisher = "Prous Science",

number = "suppl A",

}

Frédérick, R, Blanc, S, Larrieu, P, Moineaux, L, Colette, D, Fraser, G, Stroobant, V, Pilotte, L, Colaux, D, Wouters, J , Masereel, B, Van den Eynde, B & Dolušić, E 2010, 'Discovery and optimization of indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2-3 dioxygenase (IDO), a promising target for anti-cancer immunotherapy.', Drugs of the future, vol. 35, no. suppl A, pp. 181-182.

Discovery and optimization of indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2-3 dioxygenase (IDO), a promising target for anti-cancer immunotherapy. / Frédérick, Raphaël; Blanc, Sébastien; Larrieu, Pierre et al.

In: Drugs of the future, Vol. 35, No. suppl A, 2010, p. 181-182.

Research output: Contribution to journal › Literature review › peer-review

TY - JOUR

T1 - Discovery and optimization of indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2-3 dioxygenase (IDO), a promising target for anti-cancer immunotherapy.

AU - Frédérick, Raphaël

AU - Blanc, Sébastien

AU - Larrieu, Pierre

AU - Moineaux, Laurence

AU - Colette, Delphine

AU - Fraser, Graeme

AU - Stroobant, Vincent

AU - Pilotte, Luc

AU - Colaux, Didier

AU - Wouters, Johan

AU - Masereel, Bernard

AU - Van den Eynde, Benoît

AU - Dolušić, Eduard

PY - 2010

Y1 - 2010

M3 - Revue de documentation

VL - 35

SP - 181

EP - 182

JO - Drugs of the future

JF - Drugs of the future

SN - 0377-8282

IS - suppl A

ER -

Discovery and optimization of indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2-3 dioxygenase (IDO), a promising target for anti-cancer immunotherapy.

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Cite this