Copper-Catalyzed Alkenylation of Cyanamides

Antoine Nitelet, Johan Wouters, Damien F. Dewez, Gwilherm Evano

Research output: Contribution to journalArticlepeer-review


An efficient procedure for the copper-catalyzed cross-coupling between a broad range of cyanamides and iodoalkenes is reported. Upon reaction with catalytic amounts of copper(I) iodide and 2,2′-bisimidazole in the presence of cesium carbonate in DMF at 80 °C, a fast, regioselective, and stereoretentive cross-coupling occurs. This reaction, which was found to have a broad substrate scope, provides the first general entry to N-alkenylcyanamides, building blocks that hold great synthetic potential.

Original languageEnglish
Pages (from-to)6276-6279
Number of pages4
JournalOrganic Letters
Issue number23
Publication statusPublished - 1 Dec 2017


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