Projets par an
Résumé
Combretastatin A-4 (1) is a natural product isolated from the South African bushwillow tree Combretum caffrum. It has a powerful inhibitory activity on microtubule formation as well as a related antiangiogenic activity.[1-2] As such, 1 has a strong potential in the anticancer therapy, prompting the development of new derivatives.[3-6] We have turned our attention to the design of a synthetic procedure for 1 performed entirely in flow, which should enable continuous and rapid production of this useful compound and its derivatives in significant quantities.
Presented in this poster is a crucial step in this synthetic strategy - a selective semi-reduction of the triple bond of an alkyne precursor to the Z-double bond in the final product. The Lindlar-type hydrogenation in flow has been described only scarcely and for products typically more stable than Z-stilbenes.[7] We therefore set out to explore this technique and decided to expand it to a wider range of structurally various alkynes.
Presented in this poster is a crucial step in this synthetic strategy - a selective semi-reduction of the triple bond of an alkyne precursor to the Z-double bond in the final product. The Lindlar-type hydrogenation in flow has been described only scarcely and for products typically more stable than Z-stilbenes.[7] We therefore set out to explore this technique and decided to expand it to a wider range of structurally various alkynes.
langue originale | Anglais |
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Pages | Book of Abstracts, Balticum Organicum Syntheticum 2014, P016, p. 60 |
Nombre de pages | 1 |
Etat de la publication | Publié - 6 juil. 2014 |
Evénement | Balticum Organicum Syntheticum 2014 - Vilnius, Lituanie Durée: 6 juil. 2014 → 9 juil. 2014 |
Une conférence
Une conférence | Balticum Organicum Syntheticum 2014 |
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Pays | Lituanie |
La ville | Vilnius |
période | 6/07/14 → 9/07/14 |
Empreinte digitale Examiner les sujets de recherche de « Z-Selective semi-hydrogenation of alkynes under continuous flow as part of an envisaged synthesis of combretastatin A-4 ». Ensemble, ils forment une empreinte digitale unique.
Projets
- 1 Terminé
Équipement
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Physico-chimie et caractérisation (PC2)
Johan Wouters (!!Manager) & Carmela Aprile (!!Manager)
Plateforme technologique Caracterisation physico-chimiquesEquipement/installations: Plateforme technolgique
Activités
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BOSS XIV - 14th Belgian Organic Synthesis Symposium
Eduard Dolusic (Poster)
13 juil. 2014 → 18 juil. 2014Activité: Types de Participation ou d'organisation d'un événement › Participation à une conférence, un congrès
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Balticum Organicum Syntheticum 2014
Eduard Dolusic (Poster)
6 juil. 2014 → 9 juil. 2014Activité: Types de Participation ou d'organisation d'un événement › Participation à une conférence, un congrès
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Microfluidics: Fundamentals and Applications - BePCIS symposium
Eduard Dolusic (Participant)
8 mai 2014Activité: Types de Participation ou d'organisation d'un événement › Participation à un Colloque, une journée d'étude