Résumé
Presented in this poster is a crucial step in this synthetic strategy - a selective semi-reduction of the triple bond of an alkyne precursor to the Z-double bond in the final product. The Lindlar-type hydrogenation in flow has been described only scarcely and for products typically more stable than Z-stilbenes.[7] We therefore set out to explore this technique and decided to expand it to a wider range of structurally various alkynes.
| langue originale | Anglais |
|---|---|
| Pages | Book of Abstracts, Balticum Organicum Syntheticum 2014, P016, p. 60 |
| Nombre de pages | 1 |
| état | Publié - 6 juil. 2014 |
| Evénement | Balticum Organicum Syntheticum 2014 - Vilnius, Lituanie Durée: 6 juil. 2014 → 9 juil. 2014 |
Une conférence
| Une conférence | Balticum Organicum Syntheticum 2014 |
|---|---|
| Pays | Lituanie |
| La ville | Vilnius |
| période | 6/07/14 → 9/07/14 |
Empreinte digitale
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Z-Selective semi-hydrogenation of alkynes under continuous flow as part of an envisaged synthesis of combretastatin A-4. / Dolušić, Eduard; De Backer, Laurent; Collin, Stéphane; Lanners, Steve.
2014. Book of Abstracts, Balticum Organicum Syntheticum 2014, P016, p. 60 Poster présenté � Balticum Organicum Syntheticum 2014, Vilnius, Lituanie.Résultats de recherche: Contribution à un événement scientifique (non publié) › Poster
TY - CONF
T1 - Z-Selective semi-hydrogenation of alkynes under continuous flow as part of an envisaged synthesis of combretastatin A-4
AU - Dolušić, Eduard
AU - De Backer, Laurent
AU - Collin, Stéphane
AU - Lanners, Steve
PY - 2014/7/6
Y1 - 2014/7/6
N2 - Combretastatin A-4 (1) is a natural product isolated from the South African bushwillow tree Combretum caffrum. It has a powerful inhibitory activity on microtubule formation as well as a related antiangiogenic activity.[1-2] As such, 1 has a strong potential in the anticancer therapy, prompting the development of new derivatives.[3-6] We have turned our attention to the design of a synthetic procedure for 1 performed entirely in flow, which should enable continuous and rapid production of this useful compound and its derivatives in significant quantities. Presented in this poster is a crucial step in this synthetic strategy - a selective semi-reduction of the triple bond of an alkyne precursor to the Z-double bond in the final product. The Lindlar-type hydrogenation in flow has been described only scarcely and for products typically more stable than Z-stilbenes.[7] We therefore set out to explore this technique and decided to expand it to a wider range of structurally various alkynes.
AB - Combretastatin A-4 (1) is a natural product isolated from the South African bushwillow tree Combretum caffrum. It has a powerful inhibitory activity on microtubule formation as well as a related antiangiogenic activity.[1-2] As such, 1 has a strong potential in the anticancer therapy, prompting the development of new derivatives.[3-6] We have turned our attention to the design of a synthetic procedure for 1 performed entirely in flow, which should enable continuous and rapid production of this useful compound and its derivatives in significant quantities. Presented in this poster is a crucial step in this synthetic strategy - a selective semi-reduction of the triple bond of an alkyne precursor to the Z-double bond in the final product. The Lindlar-type hydrogenation in flow has been described only scarcely and for products typically more stable than Z-stilbenes.[7] We therefore set out to explore this technique and decided to expand it to a wider range of structurally various alkynes.
M3 - Poster
SP - Book of Abstracts, Balticum Organicum Syntheticum 2014, P016, p. 60
ER -