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Research Output

2014

Palladium-nanoparticle-catalyzed 1,7-palladium migration involving C-H activation, followed by intramolecular lamination: Regioselective synthesis of N 1-arylbenzotriazoles and an evaluation of their inhibitory activity toward indoleamine 2,3-dioxygenase

Takagi, K., Al-Amin, M., Hoshiya, N., Wouters, J., Sugimoto, H., Shiro, Y., Fukuda, H., Shuto, S. & Arisawa, M., 3 Jul 2014, In : Journal of Organic Chemistry. 79, 13, p. 6366-6371 6 p.

Research output: Contribution to journalArticle

Open Access
30 Downloads (Pure)

Structural analysis of some bis-(8-isopropyl-isoquinolinium) derivatives reveals a preferential folded conformation leading to a stereoselective attack by sodium borohydride

Dilly, S., Badarau, E., Dufour, F., Nistor, I., Hubert, P., Seutin, V., Wouters, J. & Liégeois, J. F., 25 Sep 2014, In : Journal of molecular structure. 1074, p. 435-440 6 p.

Research output: Contribution to journalArticle

Structural insight into cocrystallization with zwitterionic co-formers: Cocrystals of S-naproxen

Tumanova, N., Tumanov, N., Robeyns, K., Filinchuk, Y., Wouters, J. & Leyssens, T., 21 Sep 2014, In : CrystEngComm. 16, 35, p. 8185-8196 12 p.

Research output: Contribution to journalArticle

Synthesis of ferrocene-labelled 2-aminopyrimidine derivatives via homogeneous catalytic carbonylation

Fehér, C., Habuš, I., Wouters, J. & Skoda-Földes, R., 4 Sep 2014, In : Monatshefte fur Chemie. 145, 12, p. 1981-1986 6 p.

Research output: Contribution to journalArticle

23 Downloads (Pure)

Synthetic fosmidomycin analogues with altered chelating moieties do not inhibit 1-deoxy-d-xylulose 5-phosphate reductoisomerase or Plasmodium falciparum growth in vitro

Chofor, R., Risseeuw, M. D. P., Pouyez, J., Johny, C., Wouters, J., Dowd, C. S., Couch, R. D. & Van Calenbergh, S., 1 Feb 2014, In : Molecules. 19, 2, p. 2571-2587 17 p.

Research output: Contribution to journalArticle

Open Access

Thiosemicarbazide Derivatives as Novel Indolamine-2,3-dioxygenase (IDO) Inhibitors

Serra, S., Moineaux, L., Vancraeynest, C., Masereel, B., Pochet, L., Wouters, J. & Frédérick, R., 2014, Chemmedchem EFMC-ISMC 2014 Book of Abstracts. p. 280

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

2013

3-ALKENYL INDOLES AS TRYPTOPHAN 2,3-DIOXYGENASE INHIBITORS FOR THE ENHANCEMENT OF CANCER IMMUNOTHERAPY

Dolušić, E., Pilotte, L., Moineaux, L., Larrieu, P., Stroobant, V., Colau, D., Pochet, L., De Plaen, E., Uyttenhove, C., Van den Eynde, B., Wouters, J., Masereel, B., Lanners, S. & Frédérick, R., 27 May 2013, p. Book of Abstracts, Heterocycles in Bio-organic Chemistry, Riga, Latvia, 27 - 30 May 2013, PO129. 1 p.

Research output: Contribution to conferencePoster

Open Access
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Alpha-heteroatom derivatized analogues of 3-(acetylhydroxyamino)propyl phosphonic acid (FR900098) as antimalarials

Verbrugghen, T., Van Calenbergh, S., Vandurm, P., Pouyez, J., Wouters, J. & Maes, L., 10 Jan 2013, In : Journal of Medicinal Chemistry. 56, 1, p. 376-380 5 p.

Research output: Contribution to journalArticle

Direct access to 1-aryl-5-amino-1,2,4-triazoles and [1,2,4]triazolo[1,5-a] pyridines by two new single-step reactions from 1,3,4-thiadiazol-2-amines

Mammoliti, O., Quinton, E. M., Loones, K. T. J., Nguyen, A. T., Wouters, J. & Van Lommen, G., 4 Feb 2013, In : Tetrahedron. 69, 5, p. 1669-1680 12 p.

Research output: Contribution to journalArticle

Indoleamine 2,3-Dioxygenase Inhibitory Activity of Derivatives of Marine Alkaloid Tsitsikammamine A

Dolusic, E., Larrieu, P., Meinguet, C., Colette, D., Rives, A., Blanc, S., Ferain, T., Pilotte, L., Stroobant, V., Wouters, J., Van den Eynde, B., Masereel, B., Delfourne, E. & Frédérick, R., 1 Jan 2013, In : Bioorganic and medicinal chemistry letters. 23, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

3 Downloads (Pure)

"Magic" surface clustering of borazines driven by repulsive intermolecular forces

Kervyn De Meerendre, S., Kalashnyk, N., Riello, M., Moreton, B., Tasseroul, J., Wouters, J., Jones, T. S., De Vita, A., Costantini, G. & Bonifazi, D., 15 Jul 2013, In : Angewandte Chemie. International edition. 52, 29, p. 7410-7414 5 p.

Research output: Contribution to journalArticle

Mechanistic insight into the Staudinger reaction catalyzed by N-heterocyclic carbenes

Hans, M., Wouters, J., Demonceau, A. & Delaude, L., 15 Jul 2013, In : Chemistry: A European Journal. 19, 29, p. 9668-9676 9 p.

Research output: Contribution to journalArticle

Novel pharmaceutical compositions through co-crystallization of racetams and Li salts

Wouters, J., Grepioni, F., Braga, D., Kaminski, R. M., Rome, S., Aerts, L. & Quéré, L., 28 Nov 2013, In : CrystEngComm. 15, 44, p. 8898-8902 5 p.

Research output: Contribution to journalArticle

On the influence of using a zwitterionic coformer for cocrystallization: Structural focus on naproxen-proline cocrystals

Tilborg, A., Norberg, B., Wouters, J., Springuel, G. & Leyssens, T., 7 May 2013, In : CrystEngComm. 15, 17, p. 3341-3350 10 p.

Research output: Contribution to journalArticle

Polymorphism, fluorescence, and optoelectronic properties of a borazine derivative

Kervyn De Meerendre, S., Fenwick, O., Di Stasio, F., Shin, Y. S., Wouters, J., Accorsi, G., Osella, S., Beljonne, D., Cacialli, F. & Bonifazi, D., 10 Jun 2013, In : Chemistry: A European Journal. 19, 24, p. 7771-7779 9 p.

Research output: Contribution to journalArticle

Solid-state-trapped reactive ammonium carbamate self-derivative salts of prolinamide

Tilborg, A., Lanners, S., Norberg, B. & Wouters, J., 1 Dec 2013, In : ChemistryOPEN. 2, 5-6, p. 194-199 6 p.

Research output: Contribution to journalArticle

2012

Advances in pharmaceutical Co-crystal screening: Effective Co-crystal screening through structural resemblance

Springuel, G., Robeyns, K., Leyssens, T., Norberg, B. & Wouters, J., 1 Jan 2012, In : Crystal Growth and Design. 12, 1, p. 475-484 10 p.

Research output: Contribution to journalArticle

A structural study of the lithiophilite-sicklerite series

Hatert, F., Ottolini, L., Wouters, J. & Fontan, F., 1 Aug 2012, In : Canadian Mineralogist. 50, 4, p. 843-854 12 p.

Research output: Contribution to journalArticle

Chemoresistance to Valproate Treatment of Bovine Leukemia Virus-Infected Sheep; Identification of Improved HDAC Inhibitors

Gillet, N., Vandermeers, F., Brogniez, A. D., Florins, A., Nigro, A., François, C., Bouzar, A-B., STERN, E., Lambert, D. M., Wouters, J. & WILLEMS, L., 15 Nov 2012, In : Plos Pathogens. 1, 2, p. 65-82 18 p.

Research output: Contribution to journalArticle

Open Access
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Combining piracetam and lithium salts: Ionic co-crystals and co-drugs?

Braga, D., Grepioni, F., Maini, L., Capucci, D., Nanna, S., Wouters, J., Aerts, L. & Quéré, L., 25 Aug 2012, In : Chemical Communications. 48, 66, p. 8219-8221 3 p.

Research output: Contribution to journalArticle

Concluding remarks using piracetam as a learning model

Wouters, J., Tilborg, A. & Quéré, L., 2012, Pharmaceutical Salts and Co-crystals. Cambridge: Royal Society of Chemistry (RSC), Vol. 16. p. 330 - 337 8 p.

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter

Convenient one-pot formation of highly functionalized 5-halothiazoles

Dolusic, E., Modaffari, S., Pochet, L., Wouters, J., Masereel, B. & Frédérick, R., 1 Jul 2012, p. Book of Abstracts, Balticum Organicum Syntheticum, July 1-4 2012, Tallinn, Estonia, PO27, p. 74. 1 p.

Research output: Contribution to conferencePoster

Open Access
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Crystal structures of low-melting ionic transition-metal complexes with N-alkylimidazole ligands

Vander Hoogerstraete, T., Brooks, N. R., Norberg, B., Wouters, J., Van Hecke, K., Van Meervelt, L. & Binnemans, K., 7 Aug 2012, In : CrystEngComm. 14, 15, p. 4902-4911 10 p.

Research output: Contribution to journalArticle

Determination of the Absolute Configuration of Aegelinol by Crystallization of Its Inclusion Complex with β-Cyclodextrin

Elasaad, K., Alkhatib, R., Hennebelle, T., Norberg, B. & Wouters, J., 26 Oct 2012, In : Crystals. 2, 4, p. 1441-1454 14 p.

Research output: Contribution to journalArticle

Open Access
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Interuniversity Scientific Computing Facility

Vigneron, J-P., Champagne, B., Deparis, O., Henrard, L., Lambin, P., Vercauteren, D. P., Wautelet, F. & Wouters, J., 2012, In : Nanotechnologies. p. 173-174 2 p.

Research output: Contribution to journalLiterature review

Novel trisubstituted harmine derivatives with original in vitro anticancer activity

Frédérick, R., Bruyére, C., Vancraeynest, C., Reniers, J., Meinguet, C., Pochet, L., Backlund, A., Masereel, B., Kiss, R. & Wouters, J., 26 Jul 2012, In : Journal of Medicinal Chemistry. 55, 14, p. 6489-6501 13 p.

Research output: Contribution to journalArticle

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

Pilotte, L., Larrieu, P., Stroobant, V., Colau, D., Dolušić, E., Frédérick, R., De Plaen, E., Uyttenhove, C., Wouters, J., Masereel, B. & Van Den Eynde, B. J., 14 Feb 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 7, p. 2497-2502 6 p.

Research output: Contribution to journalArticle

Open Access
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Reversal of Tumoral Immune Resistance by Inhibition of Tryptophan 2,3-Dioxygenase (TDO): Design, Synthesis and Preclinical Evaluation of a Novel TDO Inhibitor.

Dolušić, E., Larrieu, P., Moineaux, L., Stroobant, V., Pilotte, L., Colaux, D., Van den Eynde, B., Masereel, B., Wouters, J. & Frédérick, R., 2012, In : ChemMedChem. p. 371 1 p.

Research output: Contribution to journalLiterature review

Open Access
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Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles

Moineaux, L., Laurent, S., Reniers, J., Dolusic, E., Galleni, M., Frère, J-M., Masereel, B., Frédérick, R. & Wouters, J., 1 Aug 2012, In : European Journal of Medicinal Chemistry. 54, p. 95-102 8 p.

Research output: Contribution to journalArticle

Open Access
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Synthesis of two new alkyne-bearing linkers used for the preparation of siRNA for labeling by click chemistry with fluorine-18

Flagothier, J., Kaisin, G., Mercier, F., Thonon, D., Teller, N., Wouters, J. & Luxen, A., 1 Aug 2012, In : Applied Radiation and Isotopes. 70, 8, p. 1549-1557 9 p.

Research output: Contribution to journalArticle

Tryptophan 2,3-Dioxygenase (TDO) Inhibitors as Anticancer Immunomodulators

Dolusic, E., Larrieu, P., Moineaux, L., Strobant, V., Pilotte, L., Colau, D., Pochet, L., De Plaen, E., Uyttenhove, C., Van den Eynde, B., Wouters, J., Masereel, B. & Frédérick, R., 15 Jul 2012, p. Programme & Book of Abstracts, BOSS XIII, KU Leuven, Belgium, 15 - 20 July 2012, P292, p. 339. 1 p.

Research output: Contribution to conferencePoster

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Unprecedented copper(I) bifluoride complexes: Synthesis, characterization and reactivity

Vergote, T., Nahra, F., Welle, A., Mager, N., Riant, O., Leyssens, T., Luhmer, M. & Wouters, J., 16 Jan 2012, In : Chemistry: A European Journal. 18, 3, p. 793-798 6 p.

Research output: Contribution to journalArticle

Zavalíaite, (Mn,Fe,Mg)(PO ), a new member of the sarcopside group from the La Empleada pegmatite, San Luis Province, Argentina

Hatert, F., Roda-Robles, E., De Parseval, P. & Wouters, J., 1 Dec 2012, In : Canadian Mineralogist. 50, 6, p. 1445-1452 8 p.

Research output: Contribution to journalArticle

2011

4-Nitro-N-phthalyl-L-tryptophan

Tilborg, A., Boittiaux, I., Norberg, B., Lambert, D. & Wouters, J., 2011, In : Acta Crystallographica. Section E. 67, 8, p. o2116

Research output: Contribution to journalArticle

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Acid-base modulation of a versatile heteroditopic calix[6]arene based receptor

Cornut, D., Marrot, J., Wouters, J. & Jabin, I., 21 Sep 2011, In : Organic and Biomolecular Chemistry. 9, 18, p. 6373-6384 12 p.

Research output: Contribution to journalArticle

A CONVENIENT FORMATION OF HIGHLY FUNCTIONALIZED 5-BROMO-1,3-THIAZOLES.

Dolusic, E., Modaffari, S., Wouters, J., Masereel, B. & Frédérick, R., 2011, p. Book of Abstracts, 15th Sigma-Aldrich Organic Synthesis Meeting, Spa, Belgium, 1-2 December 2011, p. 25. 1 p.

Research output: Contribution to conferencePoster

Open Access
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Aromatic Thiosemicarazones are inhibitors of tryptophan 2,3-Dioxygenase (TDO), an emerging target for cancer treatment

Dolusic, E., Modaffari, S., Larrieu, P., Vancraeynest, C., Pilotte, L., Colau, D., Stroobant, V., Wouters, J., Masereel, B., Van den Eynde, B. & Frédérick, R., 2011, (Unpublished) p. Book of Abstracts, ASMC 11, St. Petersburg, Russia, August 21-25, 2011, P157. 1 p.

Research output: Contribution to conferencePoster

File
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coauthor on lecture: Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase (TDO): discovery of an orally active TDO inhibitor.

Dolusic, E., Larrieu, P., Moineaux, L., Stroobant, V., Pilotte, L., Colau, D., Van den Eynde, B., Masereel, B., Wouters, J. & Frédérick, R., 2011, Book of Abstracts, Emerging Targets and Treatments: Opportunities and Challenges for Drug Design, Ghent, 25 November 2011: Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV (MedChem 2011). Vol. OC01. p. OC01

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

Dolušić, E., Larrieu, P., Blanc, S., Sapunaric, F., Pouyez, J., Moineaux, L., Colette, D., Stroobant, V., Pilotte, L., Colau, D., Ferain, T., Fraser, G., Galleni, M., Frère, J-M., Masereel, B., Van Den Eynde, B., Wouters, J. & Frédérick, R., 2011, In : European Journal of Medicinal Chemistry. 46, 7, p. 3058-3065 8 p.

Research output: Contribution to journalArticle

Electrostatically-driven assembly of MWCNTs with a europium complex

Maggini, L., Traboulsi, H., Yoosaf, K., Mohanraj, J., Wouters, J., Pietraszkiewicz, O., Pietraszkiewicz, M., Armaroli, N. & Bonifazi, D., 7 Feb 2011, In : Chemical Communications. 47, 5, p. 1625-1627 3 p.

Research output: Contribution to journalArticle

Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

Dolušić, E., Larrieu, P., Blanc, S., Sapunaric, F., Norberg, B., Moineaux, L., Colette, D., Stroobant, V., Pilotte, L., Colau, D., Ferain, T., Fraser, G., Galeni, M., Frre, J. M., Masereel, B., Van Den Eynde, B., Wouters, J. & Frédérick, R., 15 Feb 2011, In : Bioorganic and Medicinal Chemistry. 19, 4, p. 1550-1561 12 p.

Research output: Contribution to journalArticle

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Indoleamine 2,3-Dioxygenase Inhibitory Activity of Derivatives of Marine Alkaloid Tsitsikammamine A

Dolusic, E., Larrieu, P., Colette, D., Blanc, S., Rives, A., Fraser, G., Wouters, J., Kiss, R., Van den Eynde, B., Masereel, B., Delfourne, E. & Frédérick, R., 2011, Oral Communication, 25èmes Journées Franco-belges de Pharmacochimie, 19-20/05/11, Liège: De la conception à la réalisation en pharmacochimie. Vol. OC10. p. 22-22 1 p.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Open Access
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Indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2,3 dioxygenase (IDO), a promising target for anti-cancer immunotherapy

Dolusic, E., Larrieu, P., Blanc, S., Moineaux, L., Sapunaric, F., Pouyez, J., Colette, D., Fraser, G., Stroobant, V., Pilotte, L., Colau, D., Frère, J-M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2011, p. Book of Abstracts, 47èmes RICT, 6-8 juillet 2011, Lyon, France, IS08, p. 136. 1 p.

Research output: Contribution to conferencePoster

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