Ionic co-crystals of racetams: Solid-state properties enhancement of neutral active pharmaceutical ingredients via addition of Mg2+ and Ca2+ chlorides

Fabrizia Grepioni, Johan Wouters, Dario Braga, Saverio Nanna, Baptiste Fours, Gérard Coquerel, Geraldine Longfils, Sandrine Rome, Luc Aerts, Luc Quéré

Research output: Contribution to journalArticlepeer-review

Abstract

Mechanochemical and solution based reactions of solid brivaracetam (BRV) and seletracetam (SEL), antiepileptic drugs from UCB's pipeline, with the inorganic salts MgCl2 and CaCl2, yield ionic co-crystals with changed or improved physico-chemical properties with respect to pure drugs (melting point, hygroscopicity, crystal morphology). All co-crystals are characterized via a combination of solid-state techniques, i.e. single crystal and powder X-ray diffraction, variable temperature X-ray diffraction, DSC, TGA and hot-stage microscopy (HSM).

Original languageEnglish
Pages (from-to)5887-5896
Number of pages10
JournalCrystEngComm
Volume16
Issue number26
DOIs
Publication statusPublished - 14 Jul 2014
Externally publishedYes

Fingerprint

Dive into the research topics of 'Ionic co-crystals of racetams: Solid-state properties enhancement of neutral active pharmaceutical ingredients via addition of Mg<sup>2+</sup> and Ca<sup>2+</sup> chlorides'. Together they form a unique fingerprint.

Cite this