Synthesis of Tertiary Enamides by Ag2CO3-Promoted Pd-Catalyzed Alkenylation of Acyclic Secondary Amides

Arnaud Delforge, Irene Georgiou, Adrian Kremer, Johan Wouters, Davide Bonifazi

Research output: Contribution to journalArticlepeer-review


A Pd-catalyzed methodology for the preparation of tertiary enamides from acyclic secondary amides and bromo acrylates under mild reaction conditions has been developed using [Pd2(dba)3], XantPhos, and Ag2CO3 as a base. The reaction occurs through a stereospecific metal-mediated oxidative-insertion mechanism.

Original languageEnglish
Pages (from-to)4844-4847
Number of pages4
JournalOrganic Letters
Issue number19
Publication statusPublished - 7 Oct 2016

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