Synthesis and Crystallographic Characterization of a Maleimide Derivative of Tryptamine

Jean Dubois, Melwin Colaço, Grégoire Rondelet, Johan Wouters (Supervisor)

Research output: Contribution to journalArticlepeer-review

43 Downloads (Pure)


While mechanosynthesis of the target compound, 1-[2-(1H-indol-3-yl)-ethyl]-pyrrole-2,5-dione, C14 H12 N2 O2, did not yield the desired product, it instead resulted in an open intermediate. On the other hand, synthesis starting from the activated maleic anhydride yielded the final maleimide compound. The outcome of the mechanosynthesis has been evaluated by powder X-ray diffraction, and structures of both the final product and open intermediate have been confirmed using single-crystal crystallography.
Original languageEnglish
Number of pages8
Publication statusPublished - 21 Nov 2016


  • mechanosynthesis
  • grinding
  • single-crystal structure
  • powder X-ray diffraction
  • maleic anhydride
  • tryptamine


Dive into the research topics of 'Synthesis and Crystallographic Characterization of a Maleimide Derivative of Tryptamine'. Together they form a unique fingerprint.

Cite this