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Résumé
Silver nanoparticles (Ag NPs) are increasingly used in biomedical applications because of their large antimicrobial spectrum. Data in the literature on the ability of Ag NPs to perform their desired function without eliciting undesirable effects on blood elements are very limited and contradictory. We studied the impact of Ag NPs on erythrocyte integrity, platelet function and blood coagulation. Erythrocyte integrity was assessed by spectrophotometric measurement of haemoglobin release. Platelet adhesion and aggregation was determined by light transmission aggregometry and scanning electron microscopy. The calibrated thrombin generation test was used to study the impact on coagulation cascade. We demonstrated that Ag NPs induced haemolysis. They also increase platelet adhesion without having any impact on platelet aggregation. Finally, they also had procoagulant potential. Bringing all data from these tests together, the no observed effect concentration is 5 µg/mL.
langue originale | Anglais |
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Nombre de pages | 9 |
journal | Nanomaterials and Nanotechnology |
Volume | 4 |
Date de mise en ligne précoce | 18 sept. 2014 |
Les DOIs | |
Etat de la publication | Publié - 18 sept. 2014 |
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Examiner les sujets de recherche de « Impact of silver nanoparticles on haemolysis, platelet function and coagulation ». Ensemble, ils forment une empreinte digitale unique.Projets
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Nanovalid: Élaboration des méthodes de référence pour l'identification de risque, l'évaluation des risques et le LCA des nanomatériaux
Dogne, J.-M. (Co-investigateur), Lucas, S. (Co-investigateur), Saout, C. (Chercheur), TOUSSAINT, O. (Chercheur), LOZANO GARCIA, O. (Chercheur), Alpan, L. (Technicien) & Laloy, J. (Chercheur)
1/11/11 → 31/10/15
Projet: Recherche
Équipement
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Microscopie électronique
Colomer, J.-F. (!!Manager) & Charlier, C. (!!Operator)
Plateforme technologique Morphologie, imagerieEquipement/installations: Equipement
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Synthèse, Irradiation et Analyse de Matériaux (SIAM) (2016 - ...)
Louette, P. (!!Manager), Colaux, J. (!!Manager), Felten, A. (!!Manager), Tabarrant, T. (!!Operator), COME, F. (!!Operator) & Debarsy, P.-L. (!!Manager)
Plateforme technologique Synthese, irradiation et analyse des materiauxEquipement/installations: Plateforme technolgique