TY - PAT
T1 - Pyrido[3,2-d]pyrimidines as immunosuppressive agents, and their preparation, pharmaceutical compositions and use in medical treatment
AU - De Jonghe, Steven
AU - Dolusic, Eduard
AU - Gao, Ling-Jie
AU - Herdewijn, Piet
AU - Pfleiderer, Wolfgang
PY - 2009/2/5
Y1 - 2009/2/5
N2 - This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-alpha related disorders, viral diseases (including hepatitis C), erectile dysfunction and cell proliferative disorders
AB - This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-alpha related disorders, viral diseases (including hepatitis C), erectile dysfunction and cell proliferative disorders
M3 - Patent
M1 - US2009036430 (A1)
ER -