Pyrido[3,2-d]pyrimidines as immunosuppressive agents, and their preparation, pharmaceutical compositions and use in medical treatment

Steven De Jonghe; Eduard Dolusic; Ling-Jie Gao; Piet Herdewijn; Wolfgang Pfleiderer

Pyrido[3,2-d]pyrimidines as immunosuppressive agents, and their preparation, pharmaceutical compositions and use in medical treatment

Steven De Jonghe (Inventor), Eduard Dolusic (Inventor), Ling-Jie Gao (Inventor), Piet Herdewijn (Inventor), Wolfgang Pfleiderer (Inventor)

Namur Research Institute for Life Sciences

Research output: Patent

Abstract

This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-alpha related disorders, viral diseases (including hepatitis C), erectile dysfunction and cell proliferative disorders

Original language	English
Patent number	US2009036430 (A1)
IPC	A61K31/496; A61K31/519; A61K31/5377; A61K31/551; A61P17/00; A61P19/02; A61P37/06; C07D243/08; C07D413/14; C07D471/02
Publication status	Published - 5 Feb 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

3 Patent

Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents
De Jonghe, S., Dolusic, E., Gao, L-J., Herdewijn, P. & Pfleiderer, W., 8 Jan 2009, IPC No. A61K31/519; A61P35/00; C07D471/04, Patent No. WO2009003669 (A2), Priority No. US20050693899P 20050624
Research output: Patent
Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents
De Jonghe, S., Dolusic, E., Gao, L-J., Herdewijn, P. & Pfleiderer, W., 3 Jan 2008, IPC No. A61K31/519; C07D471/04; C07D487/02, Patent No. US2008004285 (A1), Priority No. US20050693899P 20050624
Research output: Patent
Preparation of pyrido(3,2-d)pyrimidines and use as immunosuppressive prodrugs
De Jonghe, S., Dolusic, E., Gao, L-J., Herdewijn, P. & Pfleiderer, W., 6 Jul 2006, IPC No. C07D471/04, Patent No. WO2006069805 (A2), Priority No. US20050693899P 20050624
Research output: Patent

Cite this

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title = "Pyrido[3,2-d]pyrimidines as immunosuppressive agents, and their preparation, pharmaceutical compositions and use in medical treatment",

abstract = "This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-alpha related disorders, viral diseases (including hepatitis C), erectile dysfunction and cell proliferative disorders",

author = "{De Jonghe}, Steven and Eduard Dolusic and Ling-Jie Gao and Piet Herdewijn and Wolfgang Pfleiderer",

year = "2009",

month = feb,

day = "5",

language = "English",

type = "Patent",

note = "US2009036430 (A1); A61K31/496; A61K31/519; A61K31/5377; A61K31/551; A61P17/00; A61P19/02; A61P37/06; C07D243/08; C07D413/14; C07D471/02",

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TY - PAT

T1 - Pyrido[3,2-d]pyrimidines as immunosuppressive agents, and their preparation, pharmaceutical compositions and use in medical treatment

AU - De Jonghe, Steven

AU - Dolusic, Eduard

AU - Gao, Ling-Jie

AU - Herdewijn, Piet

AU - Pfleiderer, Wolfgang

PY - 2009/2/5

Y1 - 2009/2/5

N2 - This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-alpha related disorders, viral diseases (including hepatitis C), erectile dysfunction and cell proliferative disorders

AB - This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-alpha related disorders, viral diseases (including hepatitis C), erectile dysfunction and cell proliferative disorders

M3 - Patent

M1 - US2009036430 (A1)

ER -

Pyrido[3,2-d]pyrimidines as immunosuppressive agents, and their preparation, pharmaceutical compositions and use in medical treatment

Abstract

UN SDGs

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Research output

Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents

Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents

Preparation of pyrido(3,2-d)pyrimidines and use as immunosuppressive prodrugs

Cite this