Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents

Steven De Jonghe; Eduard Dolusic; Ling-Jie Gao; Piet Herdewijn; Wolfgang Pfleiderer

Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents

Steven De Jonghe (Inventeur), Eduard Dolusic (Inventeur), Ling-Jie Gao (Inventeur), Piet Herdewijn (Inventeur), Wolfgang Pfleiderer (Inventeur)

Namur Research Institute for Life Sciences

Résultats de recherche: brevet › Brevet

Résumé

This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-alpha related disorders, viral diseases (including hepatitis C), erectile dysfunction and cell proliferative disorders.

langue originale	Anglais
Numéro de brevet	US2008004285 (A1)
CIB	A61K31/519; C07D471/04; C07D487/02
Etat de la publication	Publié - 3 janv. 2008

SDG des Nations Unies

Ce résultat contribue à ou aux Objectifs de développement durable suivants

3 Brevet

Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents
De Jonghe, S., Dolusic, E., Gao, L-J., Herdewijn, P. & Pfleiderer, W., 8 janv. 2009, CIB n ° A61K31/519; A61P35/00; C07D471/04, Brevet n ° WO2009003669 (A2), Numéro de priorité US20050693899P 20050624
Résultats de recherche: brevet › Brevet
Pyrido[3,2-d]pyrimidines as immunosuppressive agents, and their preparation, pharmaceutical compositions and use in medical treatment
De Jonghe, S., Dolusic, E., Gao, L-J., Herdewijn, P. & Pfleiderer, W., 5 févr. 2009, CIB n ° A61K31/496; A61K31/519; A61K31/5377; A61K31/551; A61P17/00; A61P19/02; A61P37/06; C07D243/08; C07D413/14; C07D471/02, Brevet n ° US2009036430 (A1), Numéro de priorité US20080143652 20080620
Résultats de recherche: brevet › Brevet
Preparation of pyrido(3,2-d)pyrimidines and use as immunosuppressive prodrugs
De Jonghe, S., Dolusic, E., Gao, L-J., Herdewijn, P. & Pfleiderer, W., 6 juil. 2006, CIB n ° C07D471/04, Brevet n ° WO2006069805 (A2), Numéro de priorité US20050693899P 20050624
Résultats de recherche: brevet › Brevet

Contient cette citation

@misc{299e1e9902474992ba985e677592992f,

title = "Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents",

abstract = "This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-alpha related disorders, viral diseases (including hepatitis C), erectile dysfunction and cell proliferative disorders.",

author = "{De Jonghe}, Steven and Eduard Dolusic and Ling-Jie Gao and Piet Herdewijn and Wolfgang Pfleiderer",

year = "2008",

month = jan,

day = "3",

language = "English",

type = "Patent",

note = "US2008004285 (A1); A61K31/519; C07D471/04; C07D487/02",

}

TY - PAT

T1 - Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents

AU - De Jonghe, Steven

AU - Dolusic, Eduard

AU - Gao, Ling-Jie

AU - Herdewijn, Piet

AU - Pfleiderer, Wolfgang

PY - 2008/1/3

Y1 - 2008/1/3

N2 - This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-alpha related disorders, viral diseases (including hepatitis C), erectile dysfunction and cell proliferative disorders.

AB - This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-alpha related disorders, viral diseases (including hepatitis C), erectile dysfunction and cell proliferative disorders.

M3 - Patent

M1 - US2008004285 (A1)

ER -

Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents

Résumé

SDG des Nations Unies

Empreinte digitale

Résultat de recherche

Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents

Pyrido[3,2-d]pyrimidines as immunosuppressive agents, and their preparation, pharmaceutical compositions and use in medical treatment

Preparation of pyrido(3,2-d)pyrimidines and use as immunosuppressive prodrugs

Contient cette citation