Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents

Steven De Jonghe (Inventor), Eduard Dolusic (Inventor), Ling-Jie Gao (Inventor), Piet Herdewijn (Inventor), Wolfgang Pfleiderer (Inventor)

Research output: Patent


This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-alpha related disorders, viral diseases (including hepatitis C), erectile dysfunction and cell proliferative disorders.
Original languageEnglish
Patent numberUS2008004285 (A1)
IPCA61K31/519; C07D471/04; C07D487/02
Publication statusPublished - 3 Jan 2008


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