Preparation of pyrido(3,2-d)pyrimidines and use as immunosuppressive prodrugs

Steven De Jonghe (Inventeur), Eduard Dolusic (Inventeur), Ling-Jie Gao (Inventeur), Piet Herdewijn (Inventeur), Wolfgang Pfleiderer (Inventeur)

Résultats de recherche: brevetBrevet

Résumé

This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-a related disorders, viral diseases (including hepatitis C), erectile dysfunction and cell proliferative disorders.
langue originaleAnglais
Numéro de brevetWO2006069805 (A2)
CIBC07D471/04
Etat de la publicationPublié - 6 juil. 2006

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