Preparation of pyrido(3,2-d)pyrimidines and use as immunosuppressive prodrugs

Steven De Jonghe (Inventor), Eduard Dolusic (Inventor), Ling-Jie Gao (Inventor), Piet Herdewijn (Inventor), Wolfgang Pfleiderer (Inventor)

Research output: Patent


This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-a related disorders, viral diseases (including hepatitis C), erectile dysfunction and cell proliferative disorders.
Original languageEnglish
Patent numberWO2006069805 (A2)
Publication statusPublished - 6 Jul 2006


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