Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,10-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline)

Johan Wouters; Kossay Elasaad; Bernadette Norberg; Amaury Graulich; Jean François Liégeois

doi:10.1016/j.ejmech.2010.03.020

Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,10-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline)

Johan Wouters, Kossay Elasaad, Bernadette Norberg, Amaury Graulich, Jean François Liégeois

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

Crystal structure of the three stereoisomers of 1,1′-(propane-1,3- diyl)-bis-(6,7-dimethoxy-2-methyl- 1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation.

langue originale	Anglais
Pages (de - à)	3240-3244
Nombre de pages	5
journal	European Journal of Medicinal Chemistry
Volume	45
Numéro de publication	7
Les DOIs	https://doi.org/10.1016/j.ejmech.2010.03.020
Etat de la publication	Publié - 1 juil. 2010

Accès au document

10.1016/j.ejmech.2010.03.020

Autres fichiers et liens

Link to publication in Scopus

CCDC 754726: Experimental Crystal Structure Determination
KOSSAY, E. (Contributeur), Graulich, A. (Contributeur), Liegeois, J. (Contributeur), NORBERG, B. (Contributeur) & Wouters, J. (Contributeur), Cambridge Crystallographic Data Centre, 1 janv. 2011
DOI: 10.5517/cctbc0h, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cctbc0h&sid=DataCite
Ensemble de données
CCDC 754728: Experimental Crystal Structure Determination
KOSSAY, E. (Contributeur), Graulich, A. (Contributeur), Liegeois, J. (Contributeur), NORBERG, B. (Contributeur) & Wouters, J. (Contributeur), Cambridge Crystallographic Data Centre, 1 janv. 2011
DOI: 10.5517/cctbc2k, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cctbc2k&sid=DataCite
Ensemble de données
CCDC 754727: Experimental Crystal Structure Determination
KOSSAY, E. (Contributeur), Graulich, A. (Contributeur), Liegeois, J. (Contributeur), NORBERG, B. (Contributeur) & Wouters, J. (Contributeur), Cambridge Crystallographic Data Centre, 1 janv. 2011
DOI: 10.5517/cctbc1j, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cctbc1j&sid=DataCite
Ensemble de données

Contient cette citation

@article{c82614e754cb4cd99e61c6275bb57a98,

title = "Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,10-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline)",

abstract = "Crystal structure of the three stereoisomers of 1,1′-(propane-1,3- diyl)-bis-(6,7-dimethoxy-2-methyl- 1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation.",

keywords = "Absolute configuration, Crystal structure, Potassium channel blockers, Tetrahydroisoquinoline",

author = "Johan Wouters and Kossay Elasaad and Bernadette Norberg and Amaury Graulich and Li{\'e}geois, {Jean Fran{\c c}ois}",

year = "2010",

month = jul,

day = "1",

doi = "10.1016/j.ejmech.2010.03.020",

language = "English",

volume = "45",

pages = "3240--3244",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier",

number = "7",

}

Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,10-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline). / Wouters, Johan; Elasaad, Kossay; Norberg, Bernadette et al.
Dans: European Journal of Medicinal Chemistry, Vol 45, Numéro 7, 01.07.2010, p. 3240-3244.

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

TY - JOUR

T1 - Bis-tetrahydroisoquinoline derivatives

T2 - Structure analysis of the three stereoisomers of 1,10-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline)

AU - Wouters, Johan

AU - Elasaad, Kossay

AU - Norberg, Bernadette

AU - Graulich, Amaury

AU - Liégeois, Jean François

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Crystal structure of the three stereoisomers of 1,1′-(propane-1,3- diyl)-bis-(6,7-dimethoxy-2-methyl- 1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation.

AB - Crystal structure of the three stereoisomers of 1,1′-(propane-1,3- diyl)-bis-(6,7-dimethoxy-2-methyl- 1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation.

KW - Absolute configuration

KW - Crystal structure

KW - Potassium channel blockers

KW - Tetrahydroisoquinoline

UR - http://www.scopus.com/inward/record.url?scp=77954348484&partnerID=8YFLogxK

U2 - 10.1016/j.ejmech.2010.03.020

DO - 10.1016/j.ejmech.2010.03.020

M3 - Article

C2 - 20381214

AN - SCOPUS:77954348484

SN - 0223-5234

VL - 45

SP - 3240

EP - 3244

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 7

ER -

Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,10-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline)

Résumé

Accès au document

Autres fichiers et liens

Empreinte digitale

Ensembles de données

CCDC 754726: Experimental Crystal Structure Determination

CCDC 754728: Experimental Crystal Structure Determination

CCDC 754727: Experimental Crystal Structure Determination

Contient cette citation