Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,10-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline)

Johan Wouters; Kossay Elasaad; Bernadette Norberg; Amaury Graulich; Jean François Liégeois

doi:10.1016/j.ejmech.2010.03.020

Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,10-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline)

Johan Wouters, Kossay Elasaad, Bernadette Norberg, Amaury Graulich, Jean François Liégeois

Research output: Contribution to journal › Article › peer-review

Abstract

Crystal structure of the three stereoisomers of 1,1′-(propane-1,3- diyl)-bis-(6,7-dimethoxy-2-methyl- 1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation.

Original language	English
Pages (from-to)	3240-3244
Number of pages	5
Journal	European Journal of Medicinal Chemistry
Volume	45
Issue number	7
DOIs	https://doi.org/10.1016/j.ejmech.2010.03.020
Publication status	Published - 1 Jul 2010

Keywords

Absolute configuration
Crystal structure
Potassium channel blockers
Tetrahydroisoquinoline

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10.1016/j.ejmech.2010.03.020

Cite this

@article{c82614e754cb4cd99e61c6275bb57a98,

title = "Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,10-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline)",

abstract = "Crystal structure of the three stereoisomers of 1,1′-(propane-1,3- diyl)-bis-(6,7-dimethoxy-2-methyl- 1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation.",

keywords = "Absolute configuration, Crystal structure, Potassium channel blockers, Tetrahydroisoquinoline",

author = "Johan Wouters and Kossay Elasaad and Bernadette Norberg and Amaury Graulich and Li{\'e}geois, {Jean Fran{\c c}ois}",

year = "2010",

month = jul,

day = "1",

doi = "10.1016/j.ejmech.2010.03.020",

language = "English",

volume = "45",

pages = "3240--3244",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier Masson s.r.l.",

number = "7",

}

Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,10-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline). / Wouters, Johan; Elasaad, Kossay; Norberg, Bernadette et al.
In: European Journal of Medicinal Chemistry, Vol. 45, No. 7, 01.07.2010, p. 3240-3244.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Bis-tetrahydroisoquinoline derivatives

T2 - Structure analysis of the three stereoisomers of 1,10-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline)

AU - Wouters, Johan

AU - Elasaad, Kossay

AU - Norberg, Bernadette

AU - Graulich, Amaury

AU - Liégeois, Jean François

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Crystal structure of the three stereoisomers of 1,1′-(propane-1,3- diyl)-bis-(6,7-dimethoxy-2-methyl- 1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation.

AB - Crystal structure of the three stereoisomers of 1,1′-(propane-1,3- diyl)-bis-(6,7-dimethoxy-2-methyl- 1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation.

KW - Absolute configuration

KW - Crystal structure

KW - Potassium channel blockers

KW - Tetrahydroisoquinoline

UR - http://www.scopus.com/inward/record.url?scp=77954348484&partnerID=8YFLogxK

U2 - 10.1016/j.ejmech.2010.03.020

DO - 10.1016/j.ejmech.2010.03.020

M3 - Article

C2 - 20381214

AN - SCOPUS:77954348484

SN - 0223-5234

VL - 45

SP - 3240

EP - 3244

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 7

ER -

Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,10-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline)

Abstract

Keywords

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CCDC 754727: Experimental Crystal Structure Determination

CCDC 754726: Experimental Crystal Structure Determination

CCDC 754728: Experimental Crystal Structure Determination

Cite this

Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,10-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline)

Abstract

Keywords

Access to Document

Other files and links

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Datasets

CCDC 754727: Experimental Crystal Structure Determination

CCDC 754726: Experimental Crystal Structure Determination

CCDC 754728: Experimental Crystal Structure Determination

Cite this