Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,10-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline)

Johan Wouters, Kossay Elasaad, Bernadette Norberg, Amaury Graulich, Jean François Liégeois

Research output: Contribution to journalArticle

Abstract

Crystal structure of the three stereoisomers of 1,1′-(propane-1,3- diyl)-bis-(6,7-dimethoxy-2-methyl- 1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation.

Original languageEnglish
Pages (from-to)3240-3244
Number of pages5
JournalEuropean Journal of Medicinal Chemistry
Volume45
Issue number7
DOIs
Publication statusPublished - 1 Jul 2010

Fingerprint

Tetrahydroisoquinolines
Propane
Stereoisomerism
Conformations
Crystal structure
High Pressure Liquid Chromatography
Derivatives
2-methyl-1,2,3,4-tetrahydroisoquinoline

Keywords

  • Absolute configuration
  • Crystal structure
  • Potassium channel blockers
  • Tetrahydroisoquinoline

Cite this

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abstract = "Crystal structure of the three stereoisomers of 1,1′-(propane-1,3- diyl)-bis-(6,7-dimethoxy-2-methyl- 1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation.",
keywords = "Absolute configuration, Crystal structure, Potassium channel blockers, Tetrahydroisoquinoline",
author = "Johan Wouters and Kossay Elasaad and Bernadette Norberg and Amaury Graulich and Li{\'e}geois, {Jean Fran{\cc}ois}",
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TY - JOUR

T1 - Bis-tetrahydroisoquinoline derivatives

T2 - Structure analysis of the three stereoisomers of 1,10-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline)

AU - Wouters, Johan

AU - Elasaad, Kossay

AU - Norberg, Bernadette

AU - Graulich, Amaury

AU - Liégeois, Jean François

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Crystal structure of the three stereoisomers of 1,1′-(propane-1,3- diyl)-bis-(6,7-dimethoxy-2-methyl- 1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation.

AB - Crystal structure of the three stereoisomers of 1,1′-(propane-1,3- diyl)-bis-(6,7-dimethoxy-2-methyl- 1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation.

KW - Absolute configuration

KW - Crystal structure

KW - Potassium channel blockers

KW - Tetrahydroisoquinoline

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U2 - 10.1016/j.ejmech.2010.03.020

DO - 10.1016/j.ejmech.2010.03.020

M3 - Article

VL - 45

SP - 3240

EP - 3244

JO - European journal of medicinal chemistry / Chimica therapeutica

JF - European journal of medicinal chemistry / Chimica therapeutica

SN - 0223-5234

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ER -