Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,10-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline)

Johan Wouters, Kossay Elasaad, Bernadette Norberg, Amaury Graulich, Jean François Liégeois

Research output: Contribution to journalArticle

Abstract

Crystal structure of the three stereoisomers of 1,1′-(propane-1,3- diyl)-bis-(6,7-dimethoxy-2-methyl- 1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation.

Original languageEnglish
Pages (from-to)3240-3244
Number of pages5
JournalEuropean Journal of Medicinal Chemistry
Volume45
Issue number7
DOIs
Publication statusPublished - 1 Jul 2010

Keywords

  • Absolute configuration
  • Crystal structure
  • Potassium channel blockers
  • Tetrahydroisoquinoline

Fingerprint Dive into the research topics of 'Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,10-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline)'. Together they form a unique fingerprint.

  • Datasets

    CCDC 754726: Experimental Crystal Structure Determination

    Elasaad, K. (Contributor), Graulich, A. (Contributor), Liegeois, J. (Contributor), NORBERG, B. (Contributor) & WOUTERS, J. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2011

    Dataset

    CCDC 754727: Experimental Crystal Structure Determination

    Elasaad, K. (Contributor), Graulich, A. (Contributor), Liegeois, J. (Contributor), NORBERG, B. (Contributor) & WOUTERS, J. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2011

    Dataset

    CCDC 754728: Experimental Crystal Structure Determination

    Elasaad, K. (Contributor), Graulich, A. (Contributor), Liegeois, J. (Contributor), NORBERG, B. (Contributor) & WOUTERS, J. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2011

    Dataset

    Cite this