Fluorosugars as inhibitors of bacterial enzymes

Julien A. Delbrouck; Loïc P. Chêne; Stéphane P. Vincent

doi:10.1016/b978-0-12-812733-9.00006-4

Fluorosugars as inhibitors of bacterial enzymes

Julien A. Delbrouck, Loïc P. Chêne, Stéphane P. Vincent

Résultats de recherche: Contribution dans un livre/un catalogue/un rapport/dans les actes d'une conférence › Chapitre

Résumé

Fluorinated carbohydrates play a major role in PET-Scan imaging and as diagnostic tools. They have also been instrumental tools to decipher the mechanism of key glycosyl-processing enzymes. The emergence of bacterial resistance to antibiotics has forced the scientific community to explore bacterial biosynthetic pathways in the hope to discover novel targets or novel inhibition principles that would allow for the discovery of novel antibacterial agents. This chapter will review the main synthetic strategies to access biologically relevant fluorosugars with a particular emphasis on the bacterial heptose and galactofuranose biosynthetic pathways.

langue originale	Anglais
titre	Fluorine in Life Sciences
Sous-titre	Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals Progress in Fluorine Science Series
rédacteurs en chef	Günter Haufe, Frédéric R. Leroux
Editeur	Elsevier
Chapitre	6
Pages	241-279
Nombre de pages	39
ISBN (Electronique)	9780128127339
ISBN (imprimé)	9780128127346
Les DOIs	https://doi.org/10.1016/b978-0-12-812733-9.00006-4
Etat de la publication	Publié - 2019

Série de publications

Nom	Progress in Fluorine Science
Editeur	Elsevier
Volume	4

SDG des Nations Unies

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10.1016/b978-0-12-812733-9.00006-4

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Delbrouck, J. A., Chêne, L. P., & Vincent, S. P. (2019). Fluorosugars as inhibitors of bacterial enzymes. Dans G. Haufe, & F. R. Leroux (eds.), Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals Progress in Fluorine Science Series (p. 241-279). (Progress in Fluorine Science; Vol 4). Elsevier. https://doi.org/10.1016/b978-0-12-812733-9.00006-4

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abstract = "Fluorinated carbohydrates play a major role in PET-Scan imaging and as diagnostic tools. They have also been instrumental tools to decipher the mechanism of key glycosyl-processing enzymes. The emergence of bacterial resistance to antibiotics has forced the scientific community to explore bacterial biosynthetic pathways in the hope to discover novel targets or novel inhibition principles that would allow for the discovery of novel antibacterial agents. This chapter will review the main synthetic strategies to access biologically relevant fluorosugars with a particular emphasis on the bacterial heptose and galactofuranose biosynthetic pathways.",

keywords = "Carbohydrates, Cell wall, Enzyme mechanisms, Fluorinations, Fluorosugars, Infectious diseases, Inhibitors, Mycobacterium tuberculosis, Virulence",

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Fluorosugars as inhibitors of bacterial enzymes. / Delbrouck, Julien A.; Chêne, Loïc P.; Vincent, Stéphane P.
Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals Progress in Fluorine Science Series. Ed. / Günter Haufe; Frédéric R. Leroux. Elsevier, 2019. p. 241-279 (Progress in Fluorine Science; Vol 4).

Résultats de recherche: Contribution dans un livre/un catalogue/un rapport/dans les actes d'une conférence › Chapitre

TY - CHAP

T1 - Fluorosugars as inhibitors of bacterial enzymes

AU - Delbrouck, Julien A.

AU - Chêne, Loïc P.

AU - Vincent, Stéphane P.

PY - 2019

Y1 - 2019

N2 - Fluorinated carbohydrates play a major role in PET-Scan imaging and as diagnostic tools. They have also been instrumental tools to decipher the mechanism of key glycosyl-processing enzymes. The emergence of bacterial resistance to antibiotics has forced the scientific community to explore bacterial biosynthetic pathways in the hope to discover novel targets or novel inhibition principles that would allow for the discovery of novel antibacterial agents. This chapter will review the main synthetic strategies to access biologically relevant fluorosugars with a particular emphasis on the bacterial heptose and galactofuranose biosynthetic pathways.

AB - Fluorinated carbohydrates play a major role in PET-Scan imaging and as diagnostic tools. They have also been instrumental tools to decipher the mechanism of key glycosyl-processing enzymes. The emergence of bacterial resistance to antibiotics has forced the scientific community to explore bacterial biosynthetic pathways in the hope to discover novel targets or novel inhibition principles that would allow for the discovery of novel antibacterial agents. This chapter will review the main synthetic strategies to access biologically relevant fluorosugars with a particular emphasis on the bacterial heptose and galactofuranose biosynthetic pathways.

KW - Carbohydrates

KW - Cell wall

KW - Enzyme mechanisms

KW - Fluorinations

KW - Fluorosugars

KW - Infectious diseases

KW - Inhibitors

KW - Mycobacterium tuberculosis

KW - Virulence

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U2 - 10.1016/b978-0-12-812733-9.00006-4

DO - 10.1016/b978-0-12-812733-9.00006-4

M3 - Chapter

AN - SCOPUS:85081386728

SN - 9780128127346

T3 - Progress in Fluorine Science

SP - 241

EP - 279

BT - Fluorine in Life Sciences

A2 - Haufe, Günter

A2 - Leroux, Frédéric R.

PB - Elsevier

ER -

Fluorosugars as inhibitors of bacterial enzymes

Résumé

Série de publications

SDG des Nations Unies

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