Fluorosugars as inhibitors of bacterial enzymes

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Résumé

Fluorinated carbohydrates play a major role in PET-Scan imaging and as diagnostic tools. They have also been instrumental tools to decipher the mechanism of key glycosyl-processing enzymes. The emergence of bacterial resistance to antibiotics has forced the scientific community to explore bacterial biosynthetic pathways in the hope to discover novel targets or novel inhibition principles that would allow for the discovery of novel antibacterial agents. This chapter will review the main synthetic strategies to access biologically relevant fluorosugars with a particular emphasis on the bacterial heptose and galactofuranose biosynthetic pathways.

langue originaleAnglais
titreFluorine in Life Sciences
Sous-titrePharmaceuticals, Medicinal Diagnostics, and Agrochemicals Progress in Fluorine Science Series
rédacteurs en chefGünter Haufe, Frédéric R. Leroux
EditeurElsevier
Chapitre6
Pages241-279
Nombre de pages39
ISBN (Electronique)9780128127339
ISBN (imprimé)9780128127346
Les DOIs
Etat de la publicationPublié - 2019

Série de publications

NomProgress in Fluorine Science
EditeurElsevier
Volume4

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  • Contient cette citation

    Delbrouck, J. A., Chêne, L. P., & Vincent, S. P. (2019). Fluorosugars as inhibitors of bacterial enzymes. Dans G. Haufe, & F. R. Leroux (eds.), Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals Progress in Fluorine Science Series (p. 241-279). (Progress in Fluorine Science; Vol 4). Elsevier. https://doi.org/10.1016/B978-0-12-812733-9.00006-4