Fluorosugars as inhibitors of bacterial enzymes

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter

Abstract

Fluorinated carbohydrates play a major role in PET-Scan imaging and as diagnostic tools. They have also been instrumental tools to decipher the mechanism of key glycosyl-processing enzymes. The emergence of bacterial resistance to antibiotics has forced the scientific community to explore bacterial biosynthetic pathways in the hope to discover novel targets or novel inhibition principles that would allow for the discovery of novel antibacterial agents. This chapter will review the main synthetic strategies to access biologically relevant fluorosugars with a particular emphasis on the bacterial heptose and galactofuranose biosynthetic pathways.

Original languageEnglish
Title of host publicationFluorine in Life Sciences
Subtitle of host publicationPharmaceuticals, Medicinal Diagnostics, and Agrochemicals Progress in Fluorine Science Series
EditorsGünter Haufe, Frédéric R. Leroux
PublisherElsevier
Chapter6
Pages241-279
Number of pages39
ISBN (Electronic)9780128127339
ISBN (Print)9780128127346
DOIs
Publication statusPublished - 2019

Publication series

NameProgress in Fluorine Science
PublisherElsevier
Volume4

Keywords

  • Carbohydrates
  • Cell wall
  • Enzyme mechanisms
  • Fluorinations
  • Fluorosugars
  • Infectious diseases
  • Inhibitors
  • Mycobacterium tuberculosis
  • Virulence

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  • Cite this

    Delbrouck, J. A., Chêne, L. P., & Vincent, S. P. (2019). Fluorosugars as inhibitors of bacterial enzymes. In G. Haufe, & F. R. Leroux (Eds.), Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals Progress in Fluorine Science Series (pp. 241-279). (Progress in Fluorine Science; Vol. 4). Elsevier. https://doi.org/10.1016/B978-0-12-812733-9.00006-4