@inbook{eec4e13bb127426b9ab4f2a793d9303d,
title = "Fluorosugars as inhibitors of bacterial enzymes",
abstract = "Fluorinated carbohydrates play a major role in PET-Scan imaging and as diagnostic tools. They have also been instrumental tools to decipher the mechanism of key glycosyl-processing enzymes. The emergence of bacterial resistance to antibiotics has forced the scientific community to explore bacterial biosynthetic pathways in the hope to discover novel targets or novel inhibition principles that would allow for the discovery of novel antibacterial agents. This chapter will review the main synthetic strategies to access biologically relevant fluorosugars with a particular emphasis on the bacterial heptose and galactofuranose biosynthetic pathways.",
keywords = "Carbohydrates, Cell wall, Enzyme mechanisms, Fluorinations, Fluorosugars, Infectious diseases, Inhibitors, Mycobacterium tuberculosis, Virulence",
author = "Delbrouck, {Julien A.} and Ch{\^e}ne, {Lo{\"i}c P.} and Vincent, {St{\'e}phane P.}",
year = "2019",
doi = "10.1016/b978-0-12-812733-9.00006-4",
language = "English",
isbn = "9780128127346",
series = "Progress in Fluorine Science",
publisher = "Elsevier",
pages = "241--279",
editor = "G{\"u}nter Haufe and Leroux, {Fr{\'e}d{\'e}ric R.}",
booktitle = "Fluorine in Life Sciences",
address = "Netherlands",
}
