TY - JOUR
T1 - Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer
T2 - Focus on Immunological Aspects
AU - Özcan-Wahlbrink, Mine
AU - Schifflers, Christoph
AU - Riemer, Angelika B.
PY - 2019/12/3
Y1 - 2019/12/3
N2 - Head and neck squamous cell carcinomas (HNSCC), emerging in the mucosa of the upper aerodigestive tract, are associated with either the classical risk factors, tobacco and alcohol consumption, or with infections with high-risk types of the human papillomavirus (HPV). Depending on the involvement of HPV, HNSCC follow different pathways of carcinogenesis and show distinct clinical presentations regarding survival, prognosis and treatment response. For instance, HPV-driven HNSCC exhibit an enhanced radiation response compared to their typically radioresistant HPV-negative counterparts. Although radiosensitivity of HNSCC has been studied by many research groups, the major causes for the difference in radiation responses between HPV-driven and HPV-negative HNSCC are still an open question. In this mini review, we discuss the reported cellular and immunological factors involved in the enhanced radiation response in HPV-driven HNSCC, focusing on the vital role of the immune response in the outcome of HNSCC radiotherapy.
AB - Head and neck squamous cell carcinomas (HNSCC), emerging in the mucosa of the upper aerodigestive tract, are associated with either the classical risk factors, tobacco and alcohol consumption, or with infections with high-risk types of the human papillomavirus (HPV). Depending on the involvement of HPV, HNSCC follow different pathways of carcinogenesis and show distinct clinical presentations regarding survival, prognosis and treatment response. For instance, HPV-driven HNSCC exhibit an enhanced radiation response compared to their typically radioresistant HPV-negative counterparts. Although radiosensitivity of HNSCC has been studied by many research groups, the major causes for the difference in radiation responses between HPV-driven and HPV-negative HNSCC are still an open question. In this mini review, we discuss the reported cellular and immunological factors involved in the enhanced radiation response in HPV-driven HNSCC, focusing on the vital role of the immune response in the outcome of HNSCC radiotherapy.
KW - Human papillomavirus (HPV)
KW - Head and neck squamous cell carcinoma (HNSCC)
KW - HPV-driven HNSCC
KW - oropharyngeal squamous cell carcinoma (OPSCC)
KW - radiation sensitivity
KW - Immune response
KW - human papillomavirus (HPV)
KW - immune response
KW - head and neck squamous cell carcinoma (HNSCC)
UR - http://www.scopus.com/inward/record.url?scp=85076865194&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2019.02831
DO - 10.3389/fimmu.2019.02831
M3 - Review article
VL - 10
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
M1 - 2831
ER -