Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer: Focus on Immunological Aspects

Mine Özcan-Wahlbrink, Christoph Schifflers, Angelika B. Riemer

Research output: Contribution to journalReview article

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Abstract

Head and neck squamous cell carcinomas (HNSCC), emerging in the mucosa of the upper aerodigestive tract, are associated with either the classical risk factors, tobacco and alcohol consumption, or with infections with high-risk types of the human papillomavirus (HPV). Depending on the involvement of HPV, HNSCC follow different pathways of carcinogenesis and show distinct clinical presentations regarding survival, prognosis and treatment response. For instance, HPV-driven HNSCC exhibit an enhanced radiation response compared to their typically radioresistant HPV-negative counterparts. Although radiosensitivity of HNSCC has been studied by many research groups, the major causes for the difference in radiation responses between HPV-driven and HPV-negative HNSCC are still an open question. In this mini review, we discuss the reported cellular and immunological factors involved in the enhanced radiation response in HPV-driven HNSCC, focusing on the vital role of the immune response in the outcome of HNSCC radiotherapy.
Original languageEnglish
Number of pages8
JournalFrontiers in Immunology
Publication statusPublished - 3 Dec 2019

Fingerprint

Radiation Tolerance
Head and Neck Neoplasms
Radiation
Immunologic Factors
Tobacco Use
Carcinoma, squamous cell of head and neck
Alcohol Drinking
Carcinogenesis
Mucous Membrane
Radiotherapy
Survival
Infection
Research

Keywords

  • Human papillomavirus (HPV)
  • Head and neck squamous cell carcinoma (HNSCC)
  • HPV-driven HNSCC
  • oropharyngeal squamous cell carcinoma (OPSCC)
  • radiation sensitivity
  • Immune response

Cite this

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title = "Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer: Focus on Immunological Aspects",
abstract = "Head and neck squamous cell carcinomas (HNSCC), emerging in the mucosa of the upper aerodigestive tract, are associated with either the classical risk factors, tobacco and alcohol consumption, or with infections with high-risk types of the human papillomavirus (HPV). Depending on the involvement of HPV, HNSCC follow different pathways of carcinogenesis and show distinct clinical presentations regarding survival, prognosis and treatment response. For instance, HPV-driven HNSCC exhibit an enhanced radiation response compared to their typically radioresistant HPV-negative counterparts. Although radiosensitivity of HNSCC has been studied by many research groups, the major causes for the difference in radiation responses between HPV-driven and HPV-negative HNSCC are still an open question. In this mini review, we discuss the reported cellular and immunological factors involved in the enhanced radiation response in HPV-driven HNSCC, focusing on the vital role of the immune response in the outcome of HNSCC radiotherapy.",
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journal = "Frontiers in Immunology",
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Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer : Focus on Immunological Aspects. / Özcan-Wahlbrink, Mine; Schifflers, Christoph; Riemer, Angelika B.

In: Frontiers in Immunology, 03.12.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer

T2 - Focus on Immunological Aspects

AU - Özcan-Wahlbrink, Mine

AU - Schifflers, Christoph

AU - Riemer, Angelika B.

PY - 2019/12/3

Y1 - 2019/12/3

N2 - Head and neck squamous cell carcinomas (HNSCC), emerging in the mucosa of the upper aerodigestive tract, are associated with either the classical risk factors, tobacco and alcohol consumption, or with infections with high-risk types of the human papillomavirus (HPV). Depending on the involvement of HPV, HNSCC follow different pathways of carcinogenesis and show distinct clinical presentations regarding survival, prognosis and treatment response. For instance, HPV-driven HNSCC exhibit an enhanced radiation response compared to their typically radioresistant HPV-negative counterparts. Although radiosensitivity of HNSCC has been studied by many research groups, the major causes for the difference in radiation responses between HPV-driven and HPV-negative HNSCC are still an open question. In this mini review, we discuss the reported cellular and immunological factors involved in the enhanced radiation response in HPV-driven HNSCC, focusing on the vital role of the immune response in the outcome of HNSCC radiotherapy.

AB - Head and neck squamous cell carcinomas (HNSCC), emerging in the mucosa of the upper aerodigestive tract, are associated with either the classical risk factors, tobacco and alcohol consumption, or with infections with high-risk types of the human papillomavirus (HPV). Depending on the involvement of HPV, HNSCC follow different pathways of carcinogenesis and show distinct clinical presentations regarding survival, prognosis and treatment response. For instance, HPV-driven HNSCC exhibit an enhanced radiation response compared to their typically radioresistant HPV-negative counterparts. Although radiosensitivity of HNSCC has been studied by many research groups, the major causes for the difference in radiation responses between HPV-driven and HPV-negative HNSCC are still an open question. In this mini review, we discuss the reported cellular and immunological factors involved in the enhanced radiation response in HPV-driven HNSCC, focusing on the vital role of the immune response in the outcome of HNSCC radiotherapy.

KW - Human papillomavirus (HPV)

KW - Head and neck squamous cell carcinoma (HNSCC)

KW - HPV-driven HNSCC

KW - oropharyngeal squamous cell carcinoma (OPSCC)

KW - radiation sensitivity

KW - Immune response

M3 - Review article

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

ER -