Synthesis, structural, enzymatic and cellular studies of vinyl-1H-indole analogues as potential inhibitors of tryptophan 2,3-dioxygenase (TDO), an attractive target in cancer immunotherapy.

Laurence Moineaux; Caroline Charlier; Eduard Dolusic; Pierre Larrieu; Luc Pilotte; Didier Colau; Vincent Stroobant; Paulette Charlier; Sophie Laurent; Moreno Galleni; Bernard Masereel; Benoît Van den Eynde; Johan Wouters; Raphaël Frédérick

Synthesis, structural, enzymatic and cellular studies of vinyl-1H-indole analogues as potential inhibitors of tryptophan 2,3-dioxygenase (TDO), an attractive target in cancer immunotherapy.

Laurence Moineaux, Caroline Charlier, Eduard Dolusic, Pierre Larrieu, Luc Pilotte, Didier Colau, Vincent Stroobant, Paulette Charlier, Sophie Laurent, Moreno Galleni, Bernard Masereel, Benoît Van den Eynde, Johan Wouters, Raphaël Frédérick

Research output: Contribution to conference › Poster

Original language	English
Pages	Book of Abstracts, Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV (MedChem 2011), Ghent, 25 November 2011, p. 22
Number of pages	1
Publication status	Published - 2011

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This output contributes to the following UN Sustainable Development Goals (SDGs)

4 Poster
2 Article
2 Literature review
1 Paper

3-ALKENYL INDOLES AS TRYPTOPHAN 2,3-DIOXYGENASE INHIBITORS FOR THE ENHANCEMENT OF CANCER IMMUNOTHERAPY
Dolušić, E., Pilotte, L., Moineaux, L., Larrieu, P., Stroobant, V., Colau, D., Pochet, L., De Plaen, E., Uyttenhove, C., Van den Eynde, B., Wouters, J., Masereel, B., Lanners, S. & Frédérick, R., 27 May 2013, p. Book of Abstracts, Heterocycles in Bio-organic Chemistry, Riga, Latvia, 27 - 30 May 2013, PO129. 1 p.
Research output: Contribution to conference › Poster › peer-review

Open Access
File
Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase
Pilotte, L., Larrieu, P., Stroobant, V., Colau, D., Dolušić, E., Frédérick, R., De Plaen, E., Uyttenhove, C., Wouters, J., Masereel, B. & Van Den Eynde, B. J., 14 Feb 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 7, p. 2497-2502 6 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
83 Downloads (Pure)
Reversal of Tumoral Immune Resistance by Inhibition of Tryptophan 2,3-Dioxygenase (TDO): Design, Synthesis and Preclinical Evaluation of a Novel TDO Inhibitor.
Dolušić, E., Larrieu, P., Moineaux, L., Stroobant, V., Pilotte, L., Colaux, D., Van den Eynde, B., Masereel, B., Wouters, J. & Frédérick, R., 2012, In: ChemMedChem. p. 371 1 p.
Research output: Contribution to journal › Literature review › peer-review

2 Finished

tryptophane 2,3-dioxygénase
Wouters, J. (PI)
1/10/11 → 30/09/13
Project: Research
Design, synthesis and study of enzyme modulators implicated in tryptophan metabolism and particularly in the kynurenin pathway
FREDERICK, R. (PI)
1/10/07 → 30/09/10
Project: Research

Physical Chemistry and characterization(PC2)
Wouters, J. (Manager), Aprile, C. (Manager) & Fusaro, L. (Manager)
Technological Platform Physical Chemistry and characterization
Facility/equipment: Technological Platform

4 Participation in conference

Heterocycles in Bio-organic Chemistry
Dolusic, E. (Poster)
27 May 2013
Activity: Participating in or organising an event types › Participation in conference
BOSS XIII - 13th Belgian Organic Synthesis Symposium Louvain, 15 - 20 juillet 2012
Dolusic, E. (Poster)
15 Jul 2012
Activity: Participating in or organising an event types › Participation in conference
Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV (Medchem 2011)
Dolusic, E. (Poster)
25 Nov 2011
Activity: Participating in or organising an event types › Participation in conference

Caractérisation enzymatique et structurale d'inhibiteurs indoliques de la tryptophane 2,3-dioxygénase.: Mémoire présenté pour l'obtention du grade académique de Master en Chimie "Chimie du Vivant et des Nanomatériaux" : Finalité Spécialisée.
Molle, N. (Author)Wouters, J. (Supervisor), Dolusic, E. (Jury), Moineaux, L. (Jury), Fonder, G. (Jury) & Leherte, L. (Jury), 2012
Student thesis: Master types › Master in Chemistry

Cite this

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Charlier, P., Laurent, S., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J., & Frédérick, R. (2011). Synthesis, structural, enzymatic and cellular studies of vinyl-1H-indole analogues as potential inhibitors of tryptophan 2,3-dioxygenase (TDO), an attractive target in cancer immunotherapy.. Book of Abstracts, Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV (MedChem 2011), Ghent, 25 November 2011, p. 22.

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title = "Synthesis, structural, enzymatic and cellular studies of vinyl-1H-indole analogues as potential inhibitors of tryptophan 2,3-dioxygenase (TDO), an attractive target in cancer immunotherapy.",

author = "Laurence Moineaux and Caroline Charlier and Eduard Dolusic and Pierre Larrieu and Luc Pilotte and Didier Colau and Vincent Stroobant and Paulette Charlier and Sophie Laurent and Moreno Galleni and Bernard Masereel and {Van den Eynde}, Beno{\^i}t and Johan Wouters and Rapha{\"e}l Fr{\'e}d{\'e}rick",

year = "2011",

language = "English",

pages = "Book of Abstracts, Annual One--Day Meeting on Medicinal Chemistry of SRC & KVCV (MedChem 2011), Ghent, 25 November 2011, p. 22",

}

Moineaux, L, Charlier, C, Dolusic, E, Larrieu, P, Pilotte, L, Colau, D, Stroobant, V, Charlier, P, Laurent, S, Galleni, M, Masereel, B, Van den Eynde, B, Wouters, J & Frédérick, R 2011, 'Synthesis, structural, enzymatic and cellular studies of vinyl-1H-indole analogues as potential inhibitors of tryptophan 2,3-dioxygenase (TDO), an attractive target in cancer immunotherapy.', pp. Book of Abstracts, Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV (MedChem 2011), Ghent, 25 November 2011, p. 22.

Synthesis, structural, enzymatic and cellular studies of vinyl-1H-indole analogues as potential inhibitors of tryptophan 2,3-dioxygenase (TDO), an attractive target in cancer immunotherapy. / Moineaux, Laurence; Charlier, Caroline; Dolusic, Eduard et al.
2011. Book of Abstracts, Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV (MedChem 2011), Ghent, 25 November 2011, p. 22.

Research output: Contribution to conference › Poster

TY - CONF

T1 - Synthesis, structural, enzymatic and cellular studies of vinyl-1H-indole analogues as potential inhibitors of tryptophan 2,3-dioxygenase (TDO), an attractive target in cancer immunotherapy.

AU - Moineaux, Laurence

AU - Charlier, Caroline

AU - Dolusic, Eduard

AU - Larrieu, Pierre

AU - Pilotte, Luc

AU - Colau, Didier

AU - Stroobant, Vincent

AU - Charlier, Paulette

AU - Laurent, Sophie

AU - Galleni, Moreno

AU - Masereel, Bernard

AU - Van den Eynde, Benoît

AU - Wouters, Johan

AU - Frédérick, Raphaël

PY - 2011

Y1 - 2011

M3 - Poster

SP - Book of Abstracts, Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV (MedChem 2011), Ghent, 25 November 2011, p. 22

ER -

Synthesis, structural, enzymatic and cellular studies of vinyl-1H-indole analogues as potential inhibitors of tryptophan 2,3-dioxygenase (TDO), an attractive target in cancer immunotherapy.

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Research output

Projects

Equipment

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Student theses

Cite this