Templated Chromophore Assembly by Dynamic Covalent Bonds

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

Through the simultaneous use of three orthogonal dynamic covalent reactions, namely disulfide, boronate, and acyl hydrazone formation, we conceived a facile and versatile protocol to spatially organize tailored chromophores, which absorb in the blue, red, and yellow regions, on a preprogrammed α-helix peptide. This approach allowed the assembly of the dyes in the desired ratio and spacing, as dictated by both the relative positioning and distribution of the recognition units on the peptide scaffold. Steady-state UV/Vis absorption and emission studies suggest an energy transfer from the yellow and red donors to the blue acceptor. A molecular dynamics simulation supports the experimental findings that the helical structure is maintained after the assembly and the three dyes are confined in defined conformational spaces.

langue originaleAnglais
Pages (de - à)15739-15743
Nombre de pages5
journalAngewandte Chemie International Edition
Volume54
Numéro de publication52
Les DOIs
étatPublié - 21 déc. 2015

Empreinte digitale

Covalent bonds
Chromophores
Peptides
Coloring Agents
Dyes
Hydrazones
Scaffolds (biology)
Scaffolds
Disulfides
Energy transfer
Molecular dynamics
Computer simulation

Citer ceci

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Templated Chromophore Assembly by Dynamic Covalent Bonds. / Rocard, Lou; Berezin, Andrey; De Leo, Federica; Bonifazi, Davide.

Dans: Angewandte Chemie International Edition, Vol 54, Numéro 52, 21.12.2015, p. 15739-15743.

Résultats de recherche: Contribution à un journal/une revueArticle

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