Stress-induced premature senescence: From biomarkers to likeliness of in vivo occurrence

Olivier Toussaint; José Remacle; Jean François Dierick; Thierry Pascal; Christophe Frippiat; Véronique Royer; Joao Pedro Magalhacs; Stéphanie Zdanov; Florence Chainiaux

doi:10.1023/A:1015226524335

Stress-induced premature senescence: From biomarkers to likeliness of in vivo occurrence

Olivier Toussaint, José Remacle, Jean François Dierick, Thierry Pascal, Christophe Frippiat, Véronique Royer, Joao Pedro Magalhacs, Stéphanie Zdanov, Florence Chainiaux

Unite de recherche en biologie cellulaire animale

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

The similarities between the biomarkers of stress-induced premature senescence and replicative senescence are reviewed. The possibility of existence of 'molecular scars', i.e. long-term changes observed after subcytotoxic stress and not observed in replicative senescence, is considered. Lastly, the likeliness of existence of stress-induced premature senescence in vivo is discussed. The possible effects on normal and pathological tissue ageing are predicted.

langue originale	Anglais
Pages (de - à)	13-17
Nombre de pages	5
journal	Biogerontology
Volume	3
Numéro de publication	1-2
Les DOIs	https://doi.org/10.1023/A:1015226524335
Etat de la publication	Publié - 17 avr. 2002

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10.1023/A:1015226524335

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title = "Stress-induced premature senescence: From biomarkers to likeliness of in vivo occurrence",

abstract = "The similarities between the biomarkers of stress-induced premature senescence and replicative senescence are reviewed. The possibility of existence of 'molecular scars', i.e. long-term changes observed after subcytotoxic stress and not observed in replicative senescence, is considered. Lastly, the likeliness of existence of stress-induced premature senescence in vivo is discussed. The possible effects on normal and pathological tissue ageing are predicted.",

keywords = "Ageing, Fibroblast, Senescence, Stress",

author = "Olivier Toussaint and Jos{\'e} Remacle and Dierick, {Jean Fran{\c c}ois} and Thierry Pascal and Christophe Frippiat and V{\'e}ronique Royer and Magalhacs, {Joao Pedro} and St{\'e}phanie Zdanov and Florence Chainiaux",

year = "2002",

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T2 - From biomarkers to likeliness of in vivo occurrence

AU - Toussaint, Olivier

AU - Remacle, José

AU - Dierick, Jean François

AU - Pascal, Thierry

AU - Frippiat, Christophe

AU - Royer, Véronique

AU - Magalhacs, Joao Pedro

AU - Zdanov, Stéphanie

AU - Chainiaux, Florence

PY - 2002/4/17

Y1 - 2002/4/17

N2 - The similarities between the biomarkers of stress-induced premature senescence and replicative senescence are reviewed. The possibility of existence of 'molecular scars', i.e. long-term changes observed after subcytotoxic stress and not observed in replicative senescence, is considered. Lastly, the likeliness of existence of stress-induced premature senescence in vivo is discussed. The possible effects on normal and pathological tissue ageing are predicted.

AB - The similarities between the biomarkers of stress-induced premature senescence and replicative senescence are reviewed. The possibility of existence of 'molecular scars', i.e. long-term changes observed after subcytotoxic stress and not observed in replicative senescence, is considered. Lastly, the likeliness of existence of stress-induced premature senescence in vivo is discussed. The possible effects on normal and pathological tissue ageing are predicted.

KW - Ageing

KW - Fibroblast

KW - Senescence

KW - Stress

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U2 - 10.1023/A:1015226524335

DO - 10.1023/A:1015226524335

M3 - Article

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AN - SCOPUS:0036208164

SN - 1389-5729

VL - 3

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EP - 17

JO - Biogerontology

JF - Biogerontology

IS - 1-2

ER -

Stress-induced premature senescence: From biomarkers to likeliness of in vivo occurrence

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