Stress-induced premature senescence: From biomarkers to likeliness of in vivo occurrence

Olivier Toussaint; José Remacle; Jean François Dierick; Thierry Pascal; Christophe Frippiat; Véronique Royer; Joao Pedro Magalhacs; Stéphanie Zdanov; Florence Chainiaux

doi:10.1023/A:1015226524335

Stress-induced premature senescence: From biomarkers to likeliness of in vivo occurrence

Olivier Toussaint, José Remacle, Jean François Dierick, Thierry Pascal, Christophe Frippiat, Véronique Royer, Joao Pedro Magalhacs, Stéphanie Zdanov, Florence Chainiaux

Laboratory of Cellular Biochemistry and Biology

Research output: Contribution to journal › Article › peer-review

Abstract

The similarities between the biomarkers of stress-induced premature senescence and replicative senescence are reviewed. The possibility of existence of 'molecular scars', i.e. long-term changes observed after subcytotoxic stress and not observed in replicative senescence, is considered. Lastly, the likeliness of existence of stress-induced premature senescence in vivo is discussed. The possible effects on normal and pathological tissue ageing are predicted.

Original language	English
Pages (from-to)	13-17
Number of pages	5
Journal	Biogerontology
Volume	3
Issue number	1-2
DOIs	https://doi.org/10.1023/A:1015226524335
Publication status	Published - 17 Apr 2002

Keywords

Ageing
Fibroblast
Senescence
Stress

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title = "Stress-induced premature senescence: From biomarkers to likeliness of in vivo occurrence",

abstract = "The similarities between the biomarkers of stress-induced premature senescence and replicative senescence are reviewed. The possibility of existence of 'molecular scars', i.e. long-term changes observed after subcytotoxic stress and not observed in replicative senescence, is considered. Lastly, the likeliness of existence of stress-induced premature senescence in vivo is discussed. The possible effects on normal and pathological tissue ageing are predicted.",

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AU - Toussaint, Olivier

AU - Remacle, José

AU - Dierick, Jean François

AU - Pascal, Thierry

AU - Frippiat, Christophe

AU - Royer, Véronique

AU - Magalhacs, Joao Pedro

AU - Zdanov, Stéphanie

AU - Chainiaux, Florence

PY - 2002/4/17

Y1 - 2002/4/17

N2 - The similarities between the biomarkers of stress-induced premature senescence and replicative senescence are reviewed. The possibility of existence of 'molecular scars', i.e. long-term changes observed after subcytotoxic stress and not observed in replicative senescence, is considered. Lastly, the likeliness of existence of stress-induced premature senescence in vivo is discussed. The possible effects on normal and pathological tissue ageing are predicted.

AB - The similarities between the biomarkers of stress-induced premature senescence and replicative senescence are reviewed. The possibility of existence of 'molecular scars', i.e. long-term changes observed after subcytotoxic stress and not observed in replicative senescence, is considered. Lastly, the likeliness of existence of stress-induced premature senescence in vivo is discussed. The possible effects on normal and pathological tissue ageing are predicted.

KW - Ageing

KW - Fibroblast

KW - Senescence

KW - Stress

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U2 - 10.1023/A:1015226524335

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M3 - Article

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ER -

Stress-induced premature senescence: From biomarkers to likeliness of in vivo occurrence

Abstract

Keywords

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