Stress-induced premature senescence: From biomarkers to likeliness of in vivo occurrence

Olivier Toussaint, José Remacle, Jean François Dierick, Thierry Pascal, Christophe Frippiat, Véronique Royer, Joao Pedro Magalhacs, Stéphanie Zdanov, Florence Chainiaux

Research output: Contribution to journalArticlepeer-review


The similarities between the biomarkers of stress-induced premature senescence and replicative senescence are reviewed. The possibility of existence of 'molecular scars', i.e. long-term changes observed after subcytotoxic stress and not observed in replicative senescence, is considered. Lastly, the likeliness of existence of stress-induced premature senescence in vivo is discussed. The possible effects on normal and pathological tissue ageing are predicted.

Original languageEnglish
Pages (from-to)13-17
Number of pages5
Issue number1-2
Publication statusPublished - 17 Apr 2002


  • Ageing
  • Fibroblast
  • Senescence
  • Stress


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