Spirocyclopropyl carbohydrates: Synthesis and applications

Jun Cao; Stéphane P. Vincent

doi:10.1016/j.tet.2023.133465

Spirocyclopropyl carbohydrates: Synthesis and applications

Jun Cao, Stéphane P. Vincent

Namur Institute of Structured Matter

Résultats de recherche: Contribution à un journal/une revue › Article de revue › Revue par des pairs

Résumé

This review article highlights selected advances in the synthesis of spirocyclopropyl carbohydrates and nucleosides. The cyclopropyl moiety is a versatile functional group which was demonstrated to facilitate the preparation of a vast scope of value-added compounds, such as β-C-glycosyl amino acids, spiroketals, dioxaspirolactones, among others. Moreover, this review also describes the use of spirocyclopropyl carbohydrates as glycomimetic inhibitors of biologically relevant enzymes including glycosidases, protein methyltransferase, kinase, and viral polymerases.

langue originale	Anglais
Numéro d'article	133465
journal	Tetrahedron
Volume	140
Les DOIs	https://doi.org/10.1016/j.tet.2023.133465
Etat de la publication	Publié - 29 juin 2023

Financement

We thank the China Scholarship Council ( CSC , grant 201808520092 ).

Bailleurs de fonds	Numéro du bailleur de fonds
China Scholarship Council	201808520092

Accès au document

10.1016/j.tet.2023.133465

Autres fichiers et liens

Lien vers la publication sur Scopus

Contient cette citation

@article{cc89f10ab43b4f958e8473e824c82e63,

title = "Spirocyclopropyl carbohydrates: Synthesis and applications",

abstract = "This review article highlights selected advances in the synthesis of spirocyclopropyl carbohydrates and nucleosides. The cyclopropyl moiety is a versatile functional group which was demonstrated to facilitate the preparation of a vast scope of value-added compounds, such as β-C-glycosyl amino acids, spiroketals, dioxaspirolactones, among others. Moreover, this review also describes the use of spirocyclopropyl carbohydrates as glycomimetic inhibitors of biologically relevant enzymes including glycosidases, protein methyltransferase, kinase, and viral polymerases.",

keywords = "Cyclopropanation, Glycomimetics, Ring-opening reaction, Spirocyclopropyl carbohydrates",

author = "Jun Cao and Vincent, {St{\'e}phane P.}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

month = jun,

day = "29",

doi = "10.1016/j.tet.2023.133465",

language = "English",

volume = "140",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier",

}

TY - JOUR

T1 - Spirocyclopropyl carbohydrates

T2 - Synthesis and applications

AU - Cao, Jun

AU - Vincent, Stéphane P.

PY - 2023/6/29

Y1 - 2023/6/29

N2 - This review article highlights selected advances in the synthesis of spirocyclopropyl carbohydrates and nucleosides. The cyclopropyl moiety is a versatile functional group which was demonstrated to facilitate the preparation of a vast scope of value-added compounds, such as β-C-glycosyl amino acids, spiroketals, dioxaspirolactones, among others. Moreover, this review also describes the use of spirocyclopropyl carbohydrates as glycomimetic inhibitors of biologically relevant enzymes including glycosidases, protein methyltransferase, kinase, and viral polymerases.

AB - This review article highlights selected advances in the synthesis of spirocyclopropyl carbohydrates and nucleosides. The cyclopropyl moiety is a versatile functional group which was demonstrated to facilitate the preparation of a vast scope of value-added compounds, such as β-C-glycosyl amino acids, spiroketals, dioxaspirolactones, among others. Moreover, this review also describes the use of spirocyclopropyl carbohydrates as glycomimetic inhibitors of biologically relevant enzymes including glycosidases, protein methyltransferase, kinase, and viral polymerases.

KW - Cyclopropanation

KW - Glycomimetics

KW - Ring-opening reaction

KW - Spirocyclopropyl carbohydrates

UR - http://www.scopus.com/inward/record.url?scp=85159896696&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2023.133465

DO - 10.1016/j.tet.2023.133465

M3 - Review article

AN - SCOPUS:85159896696

SN - 0040-4020

VL - 140

JO - Tetrahedron

JF - Tetrahedron

M1 - 133465

ER -

Spirocyclopropyl carbohydrates: Synthesis and applications

Résumé

Financement

Accès au document

Autres fichiers et liens

Empreinte digitale

Contient cette citation