TY - JOUR
T1 - Spirocyclopropyl carbohydrates
T2 - Synthesis and applications
AU - Cao, Jun
AU - Vincent, Stéphane P.
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/6/29
Y1 - 2023/6/29
N2 - This review article highlights selected advances in the synthesis of spirocyclopropyl carbohydrates and nucleosides. The cyclopropyl moiety is a versatile functional group which was demonstrated to facilitate the preparation of a vast scope of value-added compounds, such as β-C-glycosyl amino acids, spiroketals, dioxaspirolactones, among others. Moreover, this review also describes the use of spirocyclopropyl carbohydrates as glycomimetic inhibitors of biologically relevant enzymes including glycosidases, protein methyltransferase, kinase, and viral polymerases.
AB - This review article highlights selected advances in the synthesis of spirocyclopropyl carbohydrates and nucleosides. The cyclopropyl moiety is a versatile functional group which was demonstrated to facilitate the preparation of a vast scope of value-added compounds, such as β-C-glycosyl amino acids, spiroketals, dioxaspirolactones, among others. Moreover, this review also describes the use of spirocyclopropyl carbohydrates as glycomimetic inhibitors of biologically relevant enzymes including glycosidases, protein methyltransferase, kinase, and viral polymerases.
KW - Cyclopropanation
KW - Glycomimetics
KW - Ring-opening reaction
KW - Spirocyclopropyl carbohydrates
UR - http://www.scopus.com/inward/record.url?scp=85159896696&partnerID=8YFLogxK
U2 - 10.1016/j.tet.2023.133465
DO - 10.1016/j.tet.2023.133465
M3 - Review article
AN - SCOPUS:85159896696
SN - 0040-4020
VL - 140
JO - Tetrahedron
JF - Tetrahedron
M1 - 133465
ER -