BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions

Suzana P Salcedo; María I Marchesini; Clara Degos; Matthieu Terwagne; Kristine Von Bargen; Hubert Lepidi; Claudia K Herrmann; Thais L Santos Lacerda; Paul R C Imbert; Philippe Pierre; Lena Alexopoulou; Jean-Jacques Letesson; Diego J Comerci; Jean-Pierre Gorvel

doi:10.3389/fcimb.2013.00028

BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions

Suzana P Salcedo, María I Marchesini, Clara Degos, Matthieu Terwagne, Kristine Von Bargen, Hubert Lepidi, Claudia K Herrmann, Thais L Santos Lacerda, Paul R C Imbert, Philippe Pierre, Lena Alexopoulou, Jean-Jacques Letesson, Diego J Comerci, Jean-Pierre Gorvel

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

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Résumé

Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.

langue originale	Anglais
Pages (de - à)	28
journal	Frontiers in cellular and infection microbiology
Volume	3
Les DOIs	https://doi.org/10.3389/fcimb.2013.00028
Etat de la publication	Publié - 2013

Accès au document

10.3389/fcimb.2013.00028

fcimb-03-00028Version finale publiée, 4,09 MB

Cross-talk between Brucella and eucaryotic cells : impact of bacterial outer membrane vesicles (OMVs) on the endocytic pathway and other cellular functions
LETESSON, J., Jadot, M., Arnould, T., Raes, M. & De Bolle, X.
1/10/08 → 30/09/13
Projet: Recherche

Laboratoire de sécurité biologique au niveau 3 (BL3)
Xavier De Bolle (!!Manager)
Plateforme technologique Laboratoire de securite biologique au niveau 3
Equipement/installations: Plateforme technolgique
Microscope confocal
Charles Nicaise (!!Manager) & Francesca Cecchet (!!Manager)
Plateforme technologique Morphologie, imagerie
Equipement/installations: Equipement

Caractérisation fonctionnelle de l'ORF BMEI1674 de Brucella Melitensis et du domaine TIR qu'elle contient. Relation entre B. Melitensis et le système immunitaire inné
Auteur: Terwagne, M. & Copin, R., 2006
Superviseur: Letesson, J. (Promoteur)
Student thesis: Master types › Master en biochimie et biologie moléculaire et cellulaire

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Contient cette citation

Salcedo, S. P., Marchesini, M. I., Degos, C., Terwagne, M., Von Bargen, K., Lepidi, H., Herrmann, C. K., Santos Lacerda, T. L., Imbert, P. R. C., Pierre, P., Alexopoulou, L., Letesson, J-J., Comerci, D. J., & Gorvel, J-P. (2013). BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions. Frontiers in cellular and infection microbiology, 3, 28. https://doi.org/10.3389/fcimb.2013.00028

@article{2514d6d4353143a9ae8eeccc4b488cbc,

title = "BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions",

abstract = "Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.",

author = "Salcedo, {Suzana P} and Marchesini, {Mar{\'i}a I} and Clara Degos and Matthieu Terwagne and {Von Bargen}, Kristine and Hubert Lepidi and Herrmann, {Claudia K} and {Santos Lacerda}, {Thais L} and Imbert, {Paul R C} and Philippe Pierre and Lena Alexopoulou and Jean-Jacques Letesson and Comerci, {Diego J} and Jean-Pierre Gorvel",

year = "2013",

doi = "10.3389/fcimb.2013.00028",

language = "English",

volume = "3",

pages = "28",

journal = "Frontiers in cellular and infection microbiology",

issn = "2235-2988",

publisher = "Frontiers Media S. A.",

}

Salcedo, SP, Marchesini, MI, Degos, C, Terwagne, M, Von Bargen, K, Lepidi, H, Herrmann, CK, Santos Lacerda, TL, Imbert, PRC, Pierre, P, Alexopoulou, L, Letesson, J-J, Comerci, DJ & Gorvel, J-P 2013, 'BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions', Frontiers in cellular and infection microbiology, VOL. 3, p. 28. https://doi.org/10.3389/fcimb.2013.00028

TY - JOUR

T1 - BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions

AU - Salcedo, Suzana P

AU - Marchesini, María I

AU - Degos, Clara

AU - Terwagne, Matthieu

AU - Von Bargen, Kristine

AU - Lepidi, Hubert

AU - Herrmann, Claudia K

AU - Santos Lacerda, Thais L

AU - Imbert, Paul R C

AU - Pierre, Philippe

AU - Alexopoulou, Lena

AU - Letesson, Jean-Jacques

AU - Comerci, Diego J

AU - Gorvel, Jean-Pierre

PY - 2013

Y1 - 2013

N2 - Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.

AB - Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.

U2 - 10.3389/fcimb.2013.00028

DO - 10.3389/fcimb.2013.00028

M3 - Article

C2 - 23847770

SN - 2235-2988

VL - 3

SP - 28

JO - Frontiers in cellular and infection microbiology

JF - Frontiers in cellular and infection microbiology

ER -

BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions

Résumé

Accès au document

Projets

Cross-talk between Brucella and eucaryotic cells : impact of bacterial outer membrane vesicles (OMVs) on the endocytic pathway and other cellular functions

Équipement

Laboratoire de sécurité biologique au niveau 3 (BL3)

Microscope confocal

Thèses de l'étudiant

Caractérisation fonctionnelle de l'ORF BMEI1674 de Brucella Melitensis et du domaine TIR qu'elle contient. Relation entre B. Melitensis et le système immunitaire inné

Contient cette citation