BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions

Suzana P Salcedo, María I Marchesini, Clara Degos, Matthieu Terwagne, Kristine Von Bargen, Hubert Lepidi, Claudia K Herrmann, Thais L Santos Lacerda, Paul R C Imbert, Philippe Pierre, Lena Alexopoulou, Jean-Jacques Letesson, Diego J Comerci, Jean-Pierre Gorvel

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Abstract

Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.
Original languageEnglish
Pages (from-to)28
JournalFrontiers in cellular and infection microbiology
Volume3
DOIs
Publication statusPublished - 2013

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Brucella
Proteins
Brucellosis
Innate Immunity
Dendritic Cells
Virulence
Infection

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Salcedo, Suzana P ; Marchesini, María I ; Degos, Clara ; Terwagne, Matthieu ; Von Bargen, Kristine ; Lepidi, Hubert ; Herrmann, Claudia K ; Santos Lacerda, Thais L ; Imbert, Paul R C ; Pierre, Philippe ; Alexopoulou, Lena ; Letesson, Jean-Jacques ; Comerci, Diego J ; Gorvel, Jean-Pierre. / BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions. In: Frontiers in cellular and infection microbiology. 2013 ; Vol. 3. pp. 28.
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abstract = "Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.",
author = "Salcedo, {Suzana P} and Marchesini, {Mar{\'i}a I} and Clara Degos and Matthieu Terwagne and {Von Bargen}, Kristine and Hubert Lepidi and Herrmann, {Claudia K} and {Santos Lacerda}, {Thais L} and Imbert, {Paul R C} and Philippe Pierre and Lena Alexopoulou and Jean-Jacques Letesson and Comerci, {Diego J} and Jean-Pierre Gorvel",
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Salcedo, SP, Marchesini, MI, Degos, C, Terwagne, M, Von Bargen, K, Lepidi, H, Herrmann, CK, Santos Lacerda, TL, Imbert, PRC, Pierre, P, Alexopoulou, L, Letesson, J-J, Comerci, DJ & Gorvel, J-P 2013, 'BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions', Frontiers in cellular and infection microbiology, vol. 3, pp. 28. https://doi.org/10.3389/fcimb.2013.00028

BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions. / Salcedo, Suzana P; Marchesini, María I; Degos, Clara; Terwagne, Matthieu; Von Bargen, Kristine; Lepidi, Hubert; Herrmann, Claudia K; Santos Lacerda, Thais L; Imbert, Paul R C; Pierre, Philippe; Alexopoulou, Lena; Letesson, Jean-Jacques; Comerci, Diego J; Gorvel, Jean-Pierre.

In: Frontiers in cellular and infection microbiology, Vol. 3, 2013, p. 28.

Research output: Contribution to journalArticle

TY - JOUR

T1 - BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions

AU - Salcedo, Suzana P

AU - Marchesini, María I

AU - Degos, Clara

AU - Terwagne, Matthieu

AU - Von Bargen, Kristine

AU - Lepidi, Hubert

AU - Herrmann, Claudia K

AU - Santos Lacerda, Thais L

AU - Imbert, Paul R C

AU - Pierre, Philippe

AU - Alexopoulou, Lena

AU - Letesson, Jean-Jacques

AU - Comerci, Diego J

AU - Gorvel, Jean-Pierre

PY - 2013

Y1 - 2013

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AB - Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.

U2 - 10.3389/fcimb.2013.00028

DO - 10.3389/fcimb.2013.00028

M3 - Article

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VL - 3

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JO - Frontiers in cellular and infection microbiology

JF - Frontiers in cellular and infection microbiology

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