BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions

Suzana P Salcedo, María I Marchesini, Clara Degos, Matthieu Terwagne, Kristine Von Bargen, Hubert Lepidi, Claudia K Herrmann, Thais L Santos Lacerda, Paul R C Imbert, Philippe Pierre, Lena Alexopoulou, Jean-Jacques Letesson, Diego J Comerci, Jean-Pierre Gorvel

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Abstract

Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.
Original languageEnglish
Pages (from-to)28
JournalFrontiers in cellular and infection microbiology
Volume3
DOIs
Publication statusPublished - 2013

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    Caractérisation fonctionnelle de l'ORF BMEI1674 de Brucella melitensis et du domaine TIR qu'elle contient. : Relation entre B.melitensis et le système immunaire inné.

    Author: Terwagne, M. & Copin, R., 2006

    Supervisor: Letesson, J. (Supervisor)

    Student thesis: Master typesMaster in Biochemistry and molecular and cellular Biology

    Cite this

    Salcedo, S. P., Marchesini, M. I., Degos, C., Terwagne, M., Von Bargen, K., Lepidi, H., Herrmann, C. K., Santos Lacerda, T. L., Imbert, P. R. C., Pierre, P., Alexopoulou, L., Letesson, J-J., Comerci, D. J., & Gorvel, J-P. (2013). BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions. Frontiers in cellular and infection microbiology, 3, 28. https://doi.org/10.3389/fcimb.2013.00028