Projets par an
Résumé
Brucellae are facultative intracellular pathogens. The recent development of methods and genetically engineered strains allowed the description of cell-cycle progression of. Brucella abortus, including unipolar growth and the ordered initiation of chromosomal replication. B. abortus cell-cycle progression is coordinated with intracellular trafficking in the endosomal compartments. Bacteria are first blocked at the G1 stage, growth and chromosome replication being resumed shortly before reaching the intracellular proliferation compartment. The control mechanisms of cell cycle are similar to those reported for the bacterium. Caulobacter crescentus, and they are crucial for survival in the host cell. The development of single-cell analyses could also be applied to other bacterial pathogens to investigate their cell-cycle progression during infection. Brucella abortus is a facultative intracellular pathogen that grows unipolarly and initiates the replication of its two chromosomes in a specific order.Bacteria at the G1 stage of the cell cycle, that is, before the initiation of their chromosomal replication, are preferentially internalized in host cells.Cell-cycle progression is coordinated with trafficking in the host cell, the endosomal stage being divided into two parts: a first, long, nongrowing part, and a second part in which growth and chromosomal replication are resumed.A cell-cycle control network, conserved with the model bacterium. Caulobacter crescentus, is essential for. B. abortus virulence.
langue originale | Anglais |
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journal | Trends in Microbiology |
Les DOIs | |
Etat de la publication | Publié - 2015 |
Empreinte digitale
Examiner les sujets de recherche de « Brucella abortus Cell Cycle and Infection Are Coordinated ». Ensemble, ils forment une empreinte digitale unique.-
PDR (FRSM) BRUCELL-CYCLE: BRUCELL-CYCLE
De Bolle, X., Willemart, K. & ONG, T. A. P.
31/12/14 → …
Projet: Recherche
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Mécanismes de contrôle du cycle cellulaire de Brucella abortus en cours d'infection
1/07/13 → 30/06/15
Projet: Recherche
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PAI n°P7/28 - MICRODEV: Role of developmental processes in the virulence of human pathogens : from molecular mechanisms to novel therapeutic targets
LETESSON, J., Coenye, T., Van Dijck, P., Van Melderen, L., HOLS, P. & De Bolle, X.
1/10/12 → 30/09/17
Projet: Recherche
Équipement
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Cytométrie en flux
Jean-Yves Matroule (!!Manager) & Kevin Willemart (!!Other)
Plateforme technologique Morphologie, imagerieEquipement/installations: Equipement
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Laboratoire de sécurité biologique au niveau 3 (BL3)
Xavier De Bolle (!!Manager)
Plateforme technologique Laboratoire de securite biologique au niveau 3Equipement/installations: Plateforme technolgique
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Microscopie optique
Henri-Francois Renard (!!Manager), Alison Forrester (!!Manager), Catherine Demazy (!!Other) & Benjamin Ledoux (!!Manager)
Plateforme technologique Morphologie, imagerieEquipement/installations: Equipement
Thèses de l'étudiant
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Connecting the cell cycle and the pathogenicity of Brucella abortus. When a specific bacterial cell cycle arrest in G1 phase takes part in the colonization of mammalian cells
Auteur: Deghelt, M., 16 déc. 2013Superviseur: De Bolle, X. (Promoteur), Letesson, J. (Promoteur), Muylkens, B. (Jury), Van Doninck, K. (Président), THANBICHLER, M. (Personne externe) (Jury) & ROOP II, R. M. (Personne externe) (Jury)
Student thesis: Doc types › Docteur en Sciences
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CtrA-dependant cell cycle regulation of Brucella abortus in culture and during infection
Auteur: Francis, N., 1 déc. 2015Superviseur: De Bolle, X. (Promoteur), Renard, P. (Président), Crosson, S. (Personne externe) (Jury), Biondi, E. (Personne externe) (Jury) & Collet, J. (Personne externe) (Jury)
Student thesis: Doc types › Docteur en Sciences
Fichier -
On the link between Brucella abortus cell cycle and adaptation to its intracellular lifestyle
Auteur: Mullier, C., 24 janv. 2014Superviseur: De Bolle, X. (Promoteur), Renard, P. (Président), Jadot, M. (Jury), Matroule, J. (Jury), Salcedo, S. P. (Personne externe) (Jury) & Collet, J. (Personne externe) (Jury)
Student thesis: Doc types › Docteur en Sciences