Antagonism of the TXA2 receptor by seratrodast: A structural approach

Johan Wouters; François Durant; Bernard Masereel

doi:10.1016/S0960-894X(99)00490-4

Antagonism of the TXA2 receptor by seratrodast: A structural approach

Johan Wouters, François Durant, Bernard Masereel

Unite de recherche en chimie physique, theorique et structurale

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

The crystal structure of seratrodast (AA-2414), a potent thromboxane A2 (TXA2) receptor antagonist, served as starting point to docking studies with the modeled human TXA2 receptor. This structural approach provides rational basis for the design of new antagonists within the aryl sulfonamide family.

langue originale	Anglais
Pages (de - à)	2867-2870
Nombre de pages	4
journal	Bioorganic & Medicinal Chemistry Letters
Volume	9
Numéro de publication	19
Les DOIs	https://doi.org/10.1016/S0960-894X(99)00490-4
Etat de la publication	Publié - 4 oct. 1999

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10.1016/S0960-894X(99)00490-4

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abstract = "The crystal structure of seratrodast (AA-2414), a potent thromboxane A2 (TXA2) receptor antagonist, served as starting point to docking studies with the modeled human TXA2 receptor. This structural approach provides rational basis for the design of new antagonists within the aryl sulfonamide family.",

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Antagonism of the TXA2 receptor by seratrodast: A structural approach

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