Antagonism of the TXA2 receptor by seratrodast: A structural approach

Johan Wouters; François Durant; Bernard Masereel

doi:10.1016/S0960-894X(99)00490-4

Antagonism of the TXA2 receptor by seratrodast: A structural approach

Johan Wouters, François Durant, Bernard Masereel

Unit of theoretical and structural physico-chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The crystal structure of seratrodast (AA-2414), a potent thromboxane A2 (TXA2) receptor antagonist, served as starting point to docking studies with the modeled human TXA2 receptor. This structural approach provides rational basis for the design of new antagonists within the aryl sulfonamide family.

Original language	English
Pages (from-to)	2867-2870
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	9
Issue number	19
DOIs	https://doi.org/10.1016/S0960-894X(99)00490-4
Publication status	Published - 4 Oct 1999

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10.1016/S0960-894X(99)00490-4

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title = "Antagonism of the TXA2 receptor by seratrodast: A structural approach",

abstract = "The crystal structure of seratrodast (AA-2414), a potent thromboxane A2 (TXA2) receptor antagonist, served as starting point to docking studies with the modeled human TXA2 receptor. This structural approach provides rational basis for the design of new antagonists within the aryl sulfonamide family.",

author = "Johan Wouters and Fran{\c c}ois Durant and Bernard Masereel",

year = "1999",

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AU - Masereel, Bernard

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AB - The crystal structure of seratrodast (AA-2414), a potent thromboxane A2 (TXA2) receptor antagonist, served as starting point to docking studies with the modeled human TXA2 receptor. This structural approach provides rational basis for the design of new antagonists within the aryl sulfonamide family.

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DO - 10.1016/S0960-894X(99)00490-4

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Antagonism of the TXA2 receptor by seratrodast: A structural approach

Abstract

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