Antagonism of the TXA2 receptor by seratrodast: A structural approach

Research output: Contribution to journalArticle

Abstract

The crystal structure of seratrodast (AA-2414), a potent thromboxane A2 (TXA2) receptor antagonist, served as starting point to docking studies with the modeled human TXA2 receptor. This structural approach provides rational basis for the design of new antagonists within the aryl sulfonamide family.

Original languageEnglish
Pages (from-to)2867-2870
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Volume9
Issue number19
DOIs
Publication statusPublished - 4 Oct 1999

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