Low dose hypersensitivity following in vitro cell irradiation with charged particles: Is the mechanism the same as with X-ray radiation?

Research output: Contribution to journalArticle

Abstract

Purpose: Among the low dose effects that have been discovered during the past decade, the low dose hypersensitivity (HRS) is of prime importance. This phenomenon, compared to irradiation at higher doses used in conventional radiotherapy, enhances cell killing per unit dose at low doses and is followed by an induced radioresistance (IRR) effect. On survival fraction curves, a deviation from the linear quadratic model can be observed. HRS has mainly been studied after irradiation with sparsely ionizing radiation. Little work has been done to check its actual existence after irradiation with medium and high linear energy transfer (LET) particles. This article reviews recent studies involving HRS following irradiation of rodent and human cells with protons, alpha particles and carbon ions and assesses the applicability of a photon HRS model to charged particles. Conclusion: We propose that the HRS threshold dose and the radiosensitive parameter αs may be LET and deoxyribonucleic acid (DNA) damage-clustering dependent. Combining the use of high-LET particles at low doses and chemotherapy strategies increasing the proportion of HRS-sensitive cells could become a good candidate treatment for radioresistant cancers.

Original languageEnglish
Pages (from-to)81-9
Number of pages9
JournalInternational Journal of Radiation Biology
Volume90
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • Animals
  • Cell Survival
  • Dose-Response Relationship, Radiation
  • Humans
  • Mice
  • Models, Biological
  • Radiation Dosage
  • Radiation Tolerance
  • Rats
  • Static Electricity
  • X-Rays

Fingerprint Dive into the research topics of 'Low dose hypersensitivity following in vitro cell irradiation with charged particles: Is the mechanism the same as with X-ray radiation?'. Together they form a unique fingerprint.

  • Equipment

  • Activities

    • 4 Participation in conference

    12th Intern. Topical Meeting on Nuclear Applications of Accelerators

    Stéphane Lucas (Keynote Speaker)

    13 Nov 2015

    Activity: Participating in or organising an event typesParticipation in conference

    International Conference "Radiation Damage in Biomolecular Systems: Nanoscale Insights into Ion-Beam Cancer Therapy" (Nano-IBCT 2014)

    Stéphane Lucas (Speaker)

    27 Oct 201431 Oct 2014

    Activity: Participating in or organising an event typesParticipation in conference

    Workshop on Translational Research in Ion Beam Cancer Therapy (TRIBCT)

    Stéphane Lucas (Speaker)

    30 Sep 20142 Oct 2014

    Activity: Participating in or organising an event typesParticipation in conference

    Cite this