Activities per year
Abstract
Purpose: Among the low dose effects that have been discovered during the past decade, the low dose hypersensitivity (HRS) is of prime importance. This phenomenon, compared to irradiation at higher doses used in conventional radiotherapy, enhances cell killing per unit dose at low doses and is followed by an induced radioresistance (IRR) effect. On survival fraction curves, a deviation from the linear quadratic model can be observed. HRS has mainly been studied after irradiation with sparsely ionizing radiation. Little work has been done to check its actual existence after irradiation with medium and high linear energy transfer (LET) particles. This article reviews recent studies involving HRS following irradiation of rodent and human cells with protons, alpha particles and carbon ions and assesses the applicability of a photon HRS model to charged particles. Conclusion: We propose that the HRS threshold dose and the radiosensitive parameter αs may be LET and deoxyribonucleic acid (DNA) damage-clustering dependent. Combining the use of high-LET particles at low doses and chemotherapy strategies increasing the proportion of HRS-sensitive cells could become a good candidate treatment for radioresistant cancers.
Original language | English |
---|---|
Pages (from-to) | 81-9 |
Number of pages | 9 |
Journal | International Journal of Radiation Biology |
Volume | 90 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- Animals
- Cell Survival
- Dose-Response Relationship, Radiation
- Humans
- Mice
- Models, Biological
- Radiation Dosage
- Radiation Tolerance
- Rats
- Static Electricity
- X-Rays
Fingerprint
Dive into the research topics of 'Low dose hypersensitivity following in vitro cell irradiation with charged particles: Is the mechanism the same as with X-ray radiation?'. Together they form a unique fingerprint.Equipment
-
Synthesis, Irradiation and Analysis of Materials (SIAM)
Pierre Louette (Manager), Julien Colaux (Manager), Alexandre Felten (Manager), Tijani Tabarrant (Operator), Frederic COME (Operator) & Paul-Louis Debarsy (Manager)
Technological Platform Synthesis, Irradiation and Analysis of MaterialsFacility/equipment: Technological Platform
Activities
- 6 Participation in conference
-
12th International Topical Meeting on Nuclear Applications of Accelerators (AccApp '15)
Anne-Catherine Heuskin (Contributor)
13 Nov 2015Activity: Participating in or organising an event types › Participation in conference
-
12th Intern. Topical Meeting on Nuclear Applications of Accelerators
Stéphane Lucas (Keynote Speaker)
13 Nov 2015Activity: Participating in or organising an event types › Participation in conference
-
International Conference "Radiation Damage in Biomolecular Systems: Nanoscale Insights into Ion-Beam Cancer Therapy" (Nano-IBCT 2014)
Stéphane Lucas (Speaker)
27 Oct 2014 → 31 Oct 2014Activity: Participating in or organising an event types › Participation in conference
Student theses
-
Development of a predictive Monte Carlo code for the survival curves of in vitro irradiated cells: application to A549 non-small lung cancer cells and endothelial cells
Author: Heuskin, A., 30 Sept 2013Supervisor: Lucas, S. (Supervisor), Michiels, C. (Co-Supervisor), Houssiau, L. (Jury), Baatout, S. (External person) (Jury), Féron, O. (External person) (Jury) & Costes, S. (External person) (Jury)
Student thesis: Doc types › Doctor of Sciences