Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study

Ilya Pinchuk, Daniela Weber, Bastian Kochlik, Wolfgang Stuetz, Olivier Toussaint, Florence Debacq-Chainiaux, Martijn E.T. Dollé, Eugène H.J.M. Jansen, Efstathios S. Gonos, Ewa Sikora, Nicolle Breusing, Daniela Gradinaru, Thilo Sindlinger, María Moreno-Villanueva, Alexander Bürkle, Tilman Grune, Dov Lichtenberg

Research output: Contribution to journalArticle

Abstract

Recently, Weber et al. published a thorough investigation of the age-dependency of oxidative stress (OS) determined by the steady state concentrations of different compounds - oxidation products and antioxidants - that are in common use as biomarkers of OS in 2207 healthy individuals of the cross-sectional MARK-AGE Project. The correlations among biomarkers were significant but weak. These findings may indicate different manifestations of OS and must further be evaluated. Here, we report a refined analysis of OS based on the above-mentioned original data. We show that malondialdehyde (MDA) appears to be sensitive to both gender and age. It is significantly lower and shows a greater age-dependence in women than in men. The age-dependency of MDA in women arises in a stepwise fashion. The age-dependent slope of the steady state concentration is maximal at the age between 50 and 55 years, indicating that it may be attributed to the change of metabolism in the post-menopause. Interestingly, total glutathione (GSH) decreased with age simultaneously with the increase in MDA. Different biomarkers yield different gender- and age-dependencies. Unlike the concentration of MDA, the concentrations of the other two oxidation products, i.e. protein carbonyls and 3-nitrotyrosine were similar in men and women and appeared to be independent of age in the healthy study population. The analyzed antioxidants exhibited different gender- and age-dependencies. In conclusion, it appears that all the biomarkers assessed here reflect different types of OS and that MDA and GSH reflect the same type of OS.

Original languageEnglish
Article number101204
Pages (from-to)101204
JournalRedox Biology
Volume24
DOIs
Publication statusPublished - 1 Jun 2019

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Oxidative stress
Biomarkers
Malondialdehyde
Oxidative Stress
Antioxidants
Postmenopause
Oxidation
Metabolism
Glutathione
Population
Proteins

Keywords

  • Age-dependency
  • Biomarkers
  • Gender-associated differences
  • Oxidative stress

Cite this

Pinchuk, Ilya ; Weber, Daniela ; Kochlik, Bastian ; Stuetz, Wolfgang ; Toussaint, Olivier ; Debacq-Chainiaux, Florence ; Dollé, Martijn E.T. ; Jansen, Eugène H.J.M. ; Gonos, Efstathios S. ; Sikora, Ewa ; Breusing, Nicolle ; Gradinaru, Daniela ; Sindlinger, Thilo ; Moreno-Villanueva, María ; Bürkle, Alexander ; Grune, Tilman ; Lichtenberg, Dov. / Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study. In: Redox Biology. 2019 ; Vol. 24. pp. 101204.
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abstract = "Recently, Weber et al. published a thorough investigation of the age-dependency of oxidative stress (OS) determined by the steady state concentrations of different compounds - oxidation products and antioxidants - that are in common use as biomarkers of OS in 2207 healthy individuals of the cross-sectional MARK-AGE Project. The correlations among biomarkers were significant but weak. These findings may indicate different manifestations of OS and must further be evaluated. Here, we report a refined analysis of OS based on the above-mentioned original data. We show that malondialdehyde (MDA) appears to be sensitive to both gender and age. It is significantly lower and shows a greater age-dependence in women than in men. The age-dependency of MDA in women arises in a stepwise fashion. The age-dependent slope of the steady state concentration is maximal at the age between 50 and 55 years, indicating that it may be attributed to the change of metabolism in the post-menopause. Interestingly, total glutathione (GSH) decreased with age simultaneously with the increase in MDA. Different biomarkers yield different gender- and age-dependencies. Unlike the concentration of MDA, the concentrations of the other two oxidation products, i.e. protein carbonyls and 3-nitrotyrosine were similar in men and women and appeared to be independent of age in the healthy study population. The analyzed antioxidants exhibited different gender- and age-dependencies. In conclusion, it appears that all the biomarkers assessed here reflect different types of OS and that MDA and GSH reflect the same type of OS.",
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Pinchuk, I, Weber, D, Kochlik, B, Stuetz, W, Toussaint, O, Debacq-Chainiaux, F, Dollé, MET, Jansen, EHJM, Gonos, ES, Sikora, E, Breusing, N, Gradinaru, D, Sindlinger, T, Moreno-Villanueva, M, Bürkle, A, Grune, T & Lichtenberg, D 2019, 'Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study', Redox Biology, vol. 24, 101204, pp. 101204. https://doi.org/10.1016/j.redox.2019.101204

Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study. / Pinchuk, Ilya; Weber, Daniela; Kochlik, Bastian; Stuetz, Wolfgang; Toussaint, Olivier; Debacq-Chainiaux, Florence; Dollé, Martijn E.T.; Jansen, Eugène H.J.M.; Gonos, Efstathios S.; Sikora, Ewa; Breusing, Nicolle; Gradinaru, Daniela; Sindlinger, Thilo; Moreno-Villanueva, María; Bürkle, Alexander; Grune, Tilman; Lichtenberg, Dov.

In: Redox Biology, Vol. 24, 101204, 01.06.2019, p. 101204.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study

AU - Pinchuk, Ilya

AU - Weber, Daniela

AU - Kochlik, Bastian

AU - Stuetz, Wolfgang

AU - Toussaint, Olivier

AU - Debacq-Chainiaux, Florence

AU - Dollé, Martijn E.T.

AU - Jansen, Eugène H.J.M.

AU - Gonos, Efstathios S.

AU - Sikora, Ewa

AU - Breusing, Nicolle

AU - Gradinaru, Daniela

AU - Sindlinger, Thilo

AU - Moreno-Villanueva, María

AU - Bürkle, Alexander

AU - Grune, Tilman

AU - Lichtenberg, Dov

N1 - Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Recently, Weber et al. published a thorough investigation of the age-dependency of oxidative stress (OS) determined by the steady state concentrations of different compounds - oxidation products and antioxidants - that are in common use as biomarkers of OS in 2207 healthy individuals of the cross-sectional MARK-AGE Project. The correlations among biomarkers were significant but weak. These findings may indicate different manifestations of OS and must further be evaluated. Here, we report a refined analysis of OS based on the above-mentioned original data. We show that malondialdehyde (MDA) appears to be sensitive to both gender and age. It is significantly lower and shows a greater age-dependence in women than in men. The age-dependency of MDA in women arises in a stepwise fashion. The age-dependent slope of the steady state concentration is maximal at the age between 50 and 55 years, indicating that it may be attributed to the change of metabolism in the post-menopause. Interestingly, total glutathione (GSH) decreased with age simultaneously with the increase in MDA. Different biomarkers yield different gender- and age-dependencies. Unlike the concentration of MDA, the concentrations of the other two oxidation products, i.e. protein carbonyls and 3-nitrotyrosine were similar in men and women and appeared to be independent of age in the healthy study population. The analyzed antioxidants exhibited different gender- and age-dependencies. In conclusion, it appears that all the biomarkers assessed here reflect different types of OS and that MDA and GSH reflect the same type of OS.

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KW - Biomarkers

KW - Gender-associated differences

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