TY - JOUR
T1 - Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study
AU - Pinchuk, Ilya
AU - Weber, Daniela
AU - Kochlik, Bastian
AU - Stuetz, Wolfgang
AU - Toussaint, Olivier
AU - Debacq-Chainiaux, Florence
AU - Dollé, Martijn E.T.
AU - Jansen, Eugène H.J.M.
AU - Gonos, Efstathios S.
AU - Sikora, Ewa
AU - Breusing, Nicolle
AU - Gradinaru, Daniela
AU - Sindlinger, Thilo
AU - Moreno-Villanueva, María
AU - Bürkle, Alexander
AU - Grune, Tilman
AU - Lichtenberg, Dov
N1 - Funding Information:
The authors thank all the participants from the various recruitment centers and the European Commission for the financial support through the European Union's 7th Framework Programme Research and Innovation funding 2014-2020 large-scale integrating project “European Study to Establish Biomarkers of Human Ageing” (MARK-AGE; Grant Agreement no. 200880 ).
Funding Information:
This communication presents refined analyses of the recent investigation on the age-dependency of OS in a large cohort of middle-aged subjects enrolled in the cross-sectional MARK-AGE Project. This consortium, funded by the European Commission, already yielded better understanding of OS, based on different biomarkers measured in one large age-stratified cohort [ 13–21 ].
Publisher Copyright:
© 2019 The Authors
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Recently, Weber et al. published a thorough investigation of the age-dependency of oxidative stress (OS) determined by the steady state concentrations of different compounds - oxidation products and antioxidants - that are in common use as biomarkers of OS in 2207 healthy individuals of the cross-sectional MARK-AGE Project. The correlations among biomarkers were significant but weak. These findings may indicate different manifestations of OS and must further be evaluated. Here, we report a refined analysis of OS based on the above-mentioned original data. We show that malondialdehyde (MDA) appears to be sensitive to both gender and age. It is significantly lower and shows a greater age-dependence in women than in men. The age-dependency of MDA in women arises in a stepwise fashion. The age-dependent slope of the steady state concentration is maximal at the age between 50 and 55 years, indicating that it may be attributed to the change of metabolism in the post-menopause. Interestingly, total glutathione (GSH) decreased with age simultaneously with the increase in MDA. Different biomarkers yield different gender- and age-dependencies. Unlike the concentration of MDA, the concentrations of the other two oxidation products, i.e. protein carbonyls and 3-nitrotyrosine were similar in men and women and appeared to be independent of age in the healthy study population. The analyzed antioxidants exhibited different gender- and age-dependencies. In conclusion, it appears that all the biomarkers assessed here reflect different types of OS and that MDA and GSH reflect the same type of OS.
AB - Recently, Weber et al. published a thorough investigation of the age-dependency of oxidative stress (OS) determined by the steady state concentrations of different compounds - oxidation products and antioxidants - that are in common use as biomarkers of OS in 2207 healthy individuals of the cross-sectional MARK-AGE Project. The correlations among biomarkers were significant but weak. These findings may indicate different manifestations of OS and must further be evaluated. Here, we report a refined analysis of OS based on the above-mentioned original data. We show that malondialdehyde (MDA) appears to be sensitive to both gender and age. It is significantly lower and shows a greater age-dependence in women than in men. The age-dependency of MDA in women arises in a stepwise fashion. The age-dependent slope of the steady state concentration is maximal at the age between 50 and 55 years, indicating that it may be attributed to the change of metabolism in the post-menopause. Interestingly, total glutathione (GSH) decreased with age simultaneously with the increase in MDA. Different biomarkers yield different gender- and age-dependencies. Unlike the concentration of MDA, the concentrations of the other two oxidation products, i.e. protein carbonyls and 3-nitrotyrosine were similar in men and women and appeared to be independent of age in the healthy study population. The analyzed antioxidants exhibited different gender- and age-dependencies. In conclusion, it appears that all the biomarkers assessed here reflect different types of OS and that MDA and GSH reflect the same type of OS.
KW - Age-dependency
KW - Biomarkers
KW - Gender-associated differences
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85064430806&partnerID=8YFLogxK
U2 - 10.1016/j.redox.2019.101204
DO - 10.1016/j.redox.2019.101204
M3 - Article
C2 - 31022674
AN - SCOPUS:85064430806
SN - 2213-2317
VL - 24
SP - 101204
JO - Redox Biology
JF - Redox Biology
M1 - 101204
ER -
