• 1855 Citations
  • 20 h-Index
19962020

Research output per year

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Research Output

2010

COU254, a specific 3-carboxamide-coumarin inhibitor of coagulation factor XII, does not protect mice from acute ischemic stroke

Kraft, P., Schwarz, T., Stoll, G., Kleinschnitz, C. & Pochet, L., 15 Feb 2010, In : Experimental and Translational Stroke Medicine. 2, 1

Research output: Contribution to journalArticle

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

Maresca, A., Temperini, C., Pochet, L., Masereel, B., Scozzafava, A. & Supuran, C., 2010, In : Journal of Medicinal Chemistry. 53, p. 335-344 10 p.

Research output: Contribution to journalArticle

Pyrazolo[4,3-c]isoquinolines as potential inhibitors of NF-κB activation

Mortier, J., Frederick, R., Pochet, L., Wouters, J., Masereel, B., Ganeff, C., Remouchamps, C., Piette, J., Dejardin, E. & Talaga, P., 15 May 2010, In : Biochemical Pharmacology. 79, 10, p. 1462-1472 11 p.

Research output: Contribution to journalArticle

2009

Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs?

Robert, S., Ghiotto, J., Pirotte, B., David, J-L., Masereel, B., Pochet, L. & Dogné, J-M., 2009, In : Pharmacological Research. 59, 3, p. 160-166 7 p.

Research output: Contribution to journalArticle

Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs ?

Robert, S., Ghiotto, J., Pirotte, B., David, J-L., Masereel, B., Pochet, L. & Dogné, J-M., 2009, Abstract book - Annual Meeting of Belgian Society on Thrombosis and Haemostasis.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

2008

6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives in a new approach of the treatment of cancer cell invasion and metastasis

Kempen, I., Hemmer, M., Counerotte, S., de Tullio, P., Pirotte, B., Pochet, L., Foidart, J-M., Blacher, S., Noël, A. & Frankenne, F., 1 Dec 2008, In : European Journal of Medicinal Chemistry. 43, 12, p. 2735-2750 16 p.

Research output: Contribution to journalArticle

A potential new drug delivery system for cancer therapy: biotin-labelled beta-cyclodextrin.

Bertolla, C., Robert, S., Pochet, L. & Masereel, B., 2008, Abstract book - Small Molecules, Antibodies and Natural Products: Multiple Faces of Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Biotin tagged beta-cyclodextrin: a potential new drug targeting system for tumor therapy

Bertolla, C., Pochet, L. & Masereel, B., 2008, In : Drugs of the future. 33, suppl. A

Research output: Contribution to journalLiterature review

Design, synthesis and pharmacological evaluation of novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors.

Robert, S., Bertolla, C., Masereel, B., Dogné, J-M. & Pochet, L., 2008, Abstract book - Small Molecules, Antibodies and Natural Products: Multiple Faces of Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Microwave assisted medicinal chemistry : application to the synthesis of coumarins and cyclodextrins

Bertolla, C., Robert, S., Pochet, L. & Masereel, B., 2008, In : Chimie nouvelle. 98, p. 25-25 1 p.

Research output: Contribution to journalLiterature review

Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors

Robert, S., Bertolla, C., Masereel, B., Dogné, J-M. & Pochet, L., 2008, In : Drugs of the future. 33, suppl A

Research output: Contribution to journalLiterature review

Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors

Robert, S., Bertolla, C., Masereel, B., Dogné, J-M. & Pochet, L., 2008, In : Journal of Medicinal Chemistry. 51, p. 3077-3081 5 p.

Research output: Contribution to journalArticle

Pharmacological evaluation of 6-chloromethyl-coumarins bearing a basic moeity in the 3-position as new anticoagulants drugs

Robert, S., Frédérick, R., Masereel, B., Dogné, J-M. & Pochet, L., 2008, In : Chimie nouvelle. 98, p. 26-26 1 p.

Research output: Contribution to journalLiterature review

Structural insights into the inhibition mode of the activated coagulation factor XII by coumarins

Michaux, C., Robert, S., Del Tedesco, M., Masereel, B., Dogné, J-M. & Pochet, L., 2008, In : Drugs of the future. 33, suppl A

Research output: Contribution to journalLiterature review

Synthesis and pharmacological evaluation of a new targeted drug carrier system: beta-cyclodextrin coupled to oxytocin

Bertolla, C., Rolin, S., Evrard, B., Pochet, L. & Masereel, B., 2008, In : Bioorganic and medicinal chemistry letters. 18, 6, p. 1855-1858 4 p.

Research output: Contribution to journalArticle

2007

Beta-cyclodextrin coupled to oxytocine: synthesis and pharmacological evaluation of a new potential drug carrier system

Bertolla, C., Rolin, S., Pochet, L. & Masereel, B., 2007, Abstract Book-13th Belgian Forum of Pharmaceutical Sciences.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Le profil d'activité de thrombine: un puissant test de criblage ex vivo pour le développement d'agents anticoagulants

Robert, S., Ghiotto, J., Pirotte, B., David, J-L., Masereel, B., Pochet, L. & Dogné, J-M., 2007, Abstract Book-21èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Mechanism-based thrombin inhibitors: Design, synthesis, and molecular docking of a new selective 2-oxo-2H-1-benzopyran derivative

Frédérick, R., Robert, S., Charlier, C., Wouters, J., Masereel, B. & Pochet, L., 26 Jul 2007, In : Journal of Medicinal Chemistry. 50, 15, p. 3645-3650 6 p.

Research output: Contribution to journalArticle

Microwave assisted medicinal chemistry: application to the synthesis of coumarins and cyclodextrins

Bertolla, C., Robert, S., Pochet, L. & Masereel, B., 2007, Abstract Book-New Drugs and Drug Candidates: Recent Achievements in Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Nouveaux senseurs chimiques à base de beta-cyclodextrines comportant un motif coumarine. Synthèse, détermination structurale et étude des variations spectroscopiques

Bertolla, C., Pochet, L. & Masereel, B., 2007, Abstract Book-21ème Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Nouvelles coumarines 3-carboxamides en tant qu'inhibiteurs de facteur XIIa

Robert, S., Bertolla, C., Masereel, B., Dogné, J-M. & Pochet, L., 2007, Abstract Book-21èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Pharmacological evaluation of 6-chloromethyl-coumarins bearing a basic moiety in the 3-position as new anticoagulant drugs

Robert, S., Frédérick, R., Masereel, B., Dogné, J-M. & Pochet, L., 2007, Abstract Book-New Drugs and Drug Candidates: Recent Achievements in Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Thrombin activity profile: a powerful ex vivo screening test for the development of anticoagulant drugs

Robert, S., Ghiotto, J., Pirotte, B., David, J-L., Masereel, B., Pochet, L. & Dogné, J-M., 2007, Abstract Book-XXIst Congress of the International Society on Thrombosis and Haemostasis.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Thrombin activity profile: a powerful ex vivo screening test for the development of anticoagulant drugs

Robert, S., Ghiotto, J., Pirotte, B., David, J-L., Masereel, B., Pochet, L. & Dogné, J-M., 2007, In : Journal of Thrombosis and Haemostasis. 5, Suppl. 2

Research output: Contribution to journalLiterature review

Thrombin activity profile: a rapid, reliable and relevant ex vivo screening test for the development of anticoagulant drugs

Robert, S., Ghiotto, J., Pirotte, B., David, J-L., Masereel, B., Pochet, L. & Dogné, J-M., 2007, Abstract Book-13th Belgian Forum of Pharmaceutical Sciences.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

2006

Développement d'inhibiteurs sélectifs de thrombine : optimisation du substituant en position P1

Robert, S., Frédérick, R., Masereel, B. & Pochet, L., 2006, Abstract Book-20èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Évaluation pharmacologique de la beta-cyclodextrin couplée à l'ocytocine en tant que nouveau véhicule moléculaire

Bertolla, C., Rolin, S., Pochet, L. & Masereel, B., 2006, Abstract Book - XXèmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Synthesis, molecular modelling and enzymatic evaluation of (±) 3,5-diphenyl-2-thioxoimidazolidin-4-ones as new potential cyclooxygenase inhibitors

Gauthier, M-P., Michaux, C., Rolin, S., Vastersaegher, C., de Leval, X., Julémont, F., Pochet, L. & Masereel, B., 2006, In : Bioorganic and Medicinal Chemistry. 14, 4, p. 918-927 10 p.

Research output: Contribution to journalArticle

2005

3,6-Disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa

Frédérick, R., Robert, S., Masereel, B., Pochet, L., Pirotte, B., Charlier, C., De Ruyck, J. & Wouters, J., 1 Dec 2005, In : Journal of Medicinal Chemistry. 48, 24, p. 7592-7603 12 p.

Research output: Contribution to journalArticle

Etude de fixation des coumarines sur l'alpha-chymotrypsine

Pochet, L. & Crespin, M., 2005

Research output: Other contribution

Évaluation biologique de coumarines en tant qu'inhibiteurs du complexe facteur tissulaire/facteur VIIa

Robert, S., Frédérick, R., Masereel, B. & Pochet, L., 2005, Abstract Book-19èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Modulators of the coagulation cascade: Focus and Recent Advances in Inhibitors of Tissue Factor, Factor VIIa and their complex

Frédérick, R., Pochet, L., Charlier, C. & Masereel, B., 2005, In : Current Medicinal Chemistry. 12, 4, p. 397-417 21 p.

Research output: Contribution to journalArticle

Purification de beta-cyclodextrines monofonctionnalisées par chromatographie échangeuse ionique : étude comparative

Bertolla, C., Murray, A-M., Pochet, L. & Masereel, B., 2005, Abstract Book-19èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Structure-based design of coumarins as potent thrombin inhibitors

Frédérick, R., Robert, S., Charlier, C., De Ruyck, J., Masereel, B. & Pochet, L., 2005, Abstract Book-19èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

2004

Coumarin and isocoumarin as serine protease inhibitors

Pochet, L., Frédérick, R. & Masereel, B., 1 Jan 2004, In : Current Pharmaceutical Design. 10, 30, p. 3781-3796 16 p.

Research output: Contribution to journalArticle

Coumarins as inhibitors of serine proteases of the coagulation cascade

Frédérick, R., Robert, S., Charlier, C., Masereel, B. & Pochet, L., 2004, Abstract Book-XVIIIth International Symposium on Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Coumarins as inhibitors of serine proteases of the coagulation cascade

Frédérick, R., Robert, S., Charlier, C., Masereel, B. & Pochet, L., 2004, In : Drugs of the future. 29, A

Research output: Contribution to journalLiterature review

Coumarins as serine protease inhibitors

Pochet, L., Frédérick, R., Robert, S., Rolin, S. & Masereel, B., 2004, Abstract Book-XVIIIth International Symposium on Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Coumarins as serine protease inhibitors

Pochet, L., Frédérick, R., Robert, S., Rolin, S. & Masereel, B., 2004, In : Drugs of the future. 29, A

Research output: Contribution to journalLiterature review

Étude du mode d'interaction de coumarines avec la thrombine

Frédérick, R., Charlier, C., De Ruyck, J., Dieu, M., Robert, S., Masereel, B. & Pochet, L., 2004, Abstract Book-18èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Évaluation biologique de dérivés coumariniques en tant qu'inhibiteurs de protéases à sérine de la cascade de la coagulation

Robert, S., Frédérick, R., Masereel, B. & Pochet, L., 2004, Abstract Book-18èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Insight into the mode of action of coumarins as thrombin inhibitors

Frédérick, R., Charlier, C., De Ruyck, J., Dieu, M., Robert, S., Masereel, B. & Pochet, L., 2004, In : Fundamental and Clinical Pharmacology. 18, p. 595

Research output: Contribution to journalLiterature review

Nouveaux dérivés cyanoguanidines de beta-cyclodextrines

Bertolla, C., Pochet, L. & Masereel, B., 2004, Abstract Book-18ème Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Synthesis of new cyanoguanidine beta-cyclodextrin derivatives

Bertolla, C., Pochet, L. & Masereel, B., 2004, Abstract Book-12th International Cyclodextrin Symposium.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

2003

3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo

Kempen, I., Papapostolou, D., Thierry, N., Pochet, L., Counerotte, S., Masereel, B., Foidart, J-M., Reboud-Ravaux, M., Noel, A. & Pirotte, B., 2003, In : British Journal of Cancer. 88, p. 1111-1118 8 p.

Research output: Contribution to journalArticle

An overview of inhibitors of Na+/H+ exchanger

Masereel, B., Pochet, L. & Laeckmann, D., 2003, In : European Journal of Medicinal Chemistry. 38, p. 547-554 8 p.

Research output: Contribution to journalArticle

Investigation of the inhibition mechanism of coumarins on chymotrypsin by mass spectrometry

Pochet, L., Dieu, M., Frédérick, R., Murray, A-M., Kempen, I., Pirotte, B. & Masereel, B., 2003, In : Tetrahedron. 59, p. 4557-4561 5 p.

Research output: Contribution to journalArticle

2002

Structural approach of the mechanism of inhibition of α-chymotrypsin by coumarins

Wouters, J., Huygens, M., Pochet, L., Pirotte, B., Durant, F. & Masereel, B., 8 Apr 2002, In : Bioorganic and medicinal chemistry letters. 12, 7, p. 1109-1112 4 p.

Research output: Contribution to journalArticle

2001