6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives in a new approach of the treatment of cancer cell invasion and metastasis

I. Kempen, M. Hemmer, S. Counerotte, P. de Tullio, B. Pirotte, L. Pochet, J.-M. Foidart, S. Blacher, A. Noël, F. Frankenne

Research output: Contribution to journalArticlepeer-review

Abstract

Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated. Structure-activity relationships were deduced from biological results and will be used in further design of new active compounds. In particular, the acetoxymethyl substituent found at the 6-position of previously described active compounds can be replaced by an acetamidomethyl substituent without loss of potency; while the presence of an aryl ester function at the 3-position was preferred to a thioester or an amide function to induce marked biological activity. This work confirms the interest of aryl esters of 6-substituted coumarin-3-carboxylic acids as potential new anti-cancer agents.
Original languageEnglish
Pages (from-to)2735-2750
Number of pages16
JournalEuropean Journal of Medicinal Chemistry
Volume43
Issue number12
DOIs
Publication statusPublished - 1 Dec 2008

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